DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and AgaP_AGAP001415

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	XP_321719.5	Gene:	AgaP_AGAP001415 / 1281762	VectorBaseID:	AGAP001415	Length:	887	Species:	Anopheles gambiae

Alignment Length:	688	Identity:	161/688 - (23%)
Similarity:	259/688 - (37%)	Gaps:	178/688 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PLTMPAASLALGLTVVLLATG--NGQSQQAVTNSKQSHFWLDCSCLHLSERNATQWGRLAINASH 73
            ||:.|..:.....|.|..|.|  ||.....:.::..:|
Mosquito     7 PLSRPTKAPKCDQTFVSRAGGPSNGTFSAPMLSNPSNH--------------------------- 44

  Fly    74 SLGAKNNCLMIFIAG----MDDELVAFQLEQLQLRAGCL-DSVDIFPYLREPVIENATLAADTF- 132
                ...||.||:||    :|....:|.|....  ..|: :.:|::..::..  :.|.|....|
Mosquito    45 ----SRQCLYIFLAGPGQRVDVSFTSFSLRGTP--PDCVHEYMDVYAEVQSS--DPAELINSPFG 101

  Fly   133 ---CQHSRERSATPIYSAGRLLGLRLRFQQPPTDLASWNLTL-NASYRFLKRENFRTDGRLVPHS 193
               |.....|....:|.|     :.|.|.   ||..|....: ...|.|:....:.. |:.|..|
Mosquito   102 GRYCGPIPPRRRISLYRA-----IALSFY---TDKNSTTPDIFEGRYAFINETEYEI-GQPVIGS 157

  Fly   194 FCDFYFFASLSGEEANMGQ---GYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILFEELQLPPVV 255
            .|.:..         |..|   |...||.:|..||..:.|.|:|||:|...|.|.|.:..|
Mosquito   158 PCSYVI---------NFAQKRTGAIISPTYPGAYPKDMSCTYQFIGKPSQRVRIEFRDFDL---- 209

  Fly   256 SGGCQLDALTLFDAESAHMNSVIDVICSSRPTRRLVSTGPDLLLEFNA---SSNRTAKGFRGKYK 317
               |..|.:.:||... :.::||...|..:....|.|:...|.:.|:.   ::|...:||:|.::
Mosquito   210 ---CPFDYVRVFDGPD-NTSAVIGTYCGQQRNLVLYSSEHYLFIHFSTLQRTANTQNRGFKGIFE 270

  Fly   318 FVSNDLGVPNASVPPPAVLEAASVVVKQEKLQQEQASAAKENSLMSDVELSKPGRSFEQCKQTFD 382
            |                    :...||.:.:::......:.:                :|.|...
Mosquito   271 F--------------------SESFVKLDFIRENDGMHIRGS----------------ECDQKIL 299

  Fly   383 SRVNKSG-IFDSNQLL--LAKHALGGVVIGGSRVLQCRYEF----EAQAPERVQIRFHDFNVPT- 439
            |:...:| ::..|...  :.|             :.|||..    :||..|||::.|..|.:|.
Mosquito   300 SKKESTGFVYSPNYPFPYIPK-------------VVCRYFVYGMQDAQNLERVKLEFSIFEIPKG 351

  Fly   440 EH--ENSTGCQPGDALHVVTELRGRYETQEL----------LCGAFLPKPLMSSGQQLHLQFVGK 492
            ||  ::.:.|..|   ::...|:|    ||:          |||..||..::|.|.:|.:.|
Mosquito   352 EHKDKSESNCTDG---YLKVYLKG----QEVADAYDKFDHELCGGELPHAVISDGPRLVMVF--- 406

  Fly   493 YPPTMTNKVQYYGFRAEYRFLTNFGIMSGIQKEG-CSFVYNSSERISGLFHSPNFPGYYLENVVC 556
                .:.::|..||:|:|.|.|.:.|......:| |||.|.|:.|..|.|:||.:|..|.....|
Mosquito   407 ----SSGELQGRGFKAKYTFETEYKIPGTAAPDGTCSFTYRSTSRKKGEFNSPRYPSNYPSETNC 467

  Fly   557 NYYFYGASDERVVLHFTYFDIEGIGS-----------CDHQTASDYIEFSNFMSTDRKFSRYCGK 610
            :|.|....:|:|.:.|.:|.::..|:           |.......|:.:.:  .|||...|||..
Mosquito   468 SYVFLATPNEQVTIVFDHFKVKADGANTTGGAYGASVCFEDWLEMYVLYRD--GTDRFLGRYCSL 530

  Fly   611 LPDFEMRSD-GRF-FRVTLHSNDRFVAIGFRALYTFET 646
            .....:.|. |.. .||.||::...||.||:|.|.|||
Mosquito   531 TAPGPVESPRGAVGIRVVLHTDLENVASGFKARYIFET 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	34/128 (27%)
		CUB	<414..512	CDD:238001	33/114 (29%)
		CUB	527..644	CDD:238001	40/129 (31%)
AgaP_AGAP001415	XP_321719.5	CUB	27..142	CDD:238001	28/157 (18%)
		CUB	159..271	CDD:238001	34/128 (27%)
		CUB	303..422	CDD:238001	36/145 (25%)
		CUB	438..566	CDD:238001	40/129 (31%)
		CUB	576..699	CDD:238001
		LDLa	718..754	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179423at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920