DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34402 and CSMD3

DIOPT Version :9

Sequence 1:	NP_001097756.1	Gene:	CG34402 / 41513	FlyBaseID:	FBgn0085431	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_937756.1	Gene:	CSMD3 / 114788	HGNCID:	19291	Length:	3707	Species:	Homo sapiens

Alignment Length:	583	Identity:	117/583 - (20%)
Similarity:	191/583 - (32%)	Gaps:	176/583 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 TPIYSAGRLLGLR----------LRFQQPPTDLASWNLTLNASYRFLKRENFRTDGRLVPHSFCD 196
            ||:|      |:|          |||:      ..:...|......:.:||.:....:   ..|
Human   669 TPLY------GIREGDGFSNRDVLRFE------CQFGFELIGEKSIVCQENNQWSANI---PIC- 717

  Fly   197 FYFFASLSGEEANMGQGYFHSPQFPAHYPAHIKCAYKFIGRPDTHVEILFEELQLPPVVSGGCQL 261
              .|..||...|.||.  ..||.:|..|..::.|.:..|..|.:.:.:.|.:..|.      .|.
Human   718 --IFPCLSNFTAPMGT--VLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE------SQF 772

  Fly   262 DALTLFDAESAHMNSVIDVICSSRPTRRLVSTGPDLLLEFNASSNRTAKGFRGKYK-FVSNDLGV 325
            |.|.:.|.:|.. :.::.....:.....|.|....|.|||.|..:.:.:||...|. |..|:  .
Human   773 DFLAVKDGDSPE-SPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE--C 834

  Fly   326 PNASVPPPA-------VLEAASVVVKQEKLQQEQASAAKENSLMSDVELSKPGRSFEQCKQTFDS 383
            |:..:|..|       .|.::..|:.:|...:.|.:......||                   |.
Human   835 PDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILM-------------------DG 880

  Fly   384 RVNKSGIFDSNQLLLAKH--ALGGVVIGG------SRVLQCRYEFEAQAPERVQIRFHDFNVPTE 440
            :|..||:..........|  |..||::..      ...|.|.:..||:....::|.|..|.....
Human   881 KVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN 945

  Fly   441 HENSTGCQPGDALHVVTELRGRYETQELLCGAFLPKPLMSSGQQLHLQFVGKYPPTMTNKVQYYG 505
            ::   ..:..|..::::.|.|.|.      |..:|:.|.||...::|.|      |..|.....|
Human   946 YD---VLEVHDGPNLLSPLLGSYN------GTQVPQFLFSSSNFIYLLF------TTDNSRSNNG 995

  Fly   506 FRAEYRFLT--------------------NFGIMSGIQKEGCSFVYNSSERI------------- 537
            |:..|..:|                    :|.|.|.:     ||..:|..|:
Human   996 FKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTV-----SFSCDSGYRLSHEEPLLCEKNHW 1055

  Fly   538 -------------------SGLFHSPNFPGYYLENVVCNYYFYGASDERVVLHFTYFDIEGIGSC 583
                               ||...||.:|.:|..::.|.:.......:.|..:|..|.:|
Human  1056 WSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLE----- 1115

  Fly   584 DHQTASDYIEFSNFMSTDRKFSRYCGK-LP-------------------DFEMRSDGRFFRVT 626
            ||.   ||:..:...|..:..:|..|. ||                   ||.:..:|  |.:|
Human  1116 DHH---DYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEG--FNIT 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34402	NP_001097756.1	CUB	195..318	CDD:238001	31/123 (25%)
		CUB	<414..512	CDD:238001	23/97 (24%)
		CUB	527..644	CDD:238001	29/152 (19%)
CSMD3	NP_937756.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		CUB	65..171	CDD:238001
		CCP	178..236	CDD:153056
		CUB	257..343	CDD:238001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..435
		CCP	486..544	CDD:153056
		CUB	548..656	CDD:238001
		CCP	664..718	CDD:153056	12/66 (18%)
		CUB	721..828	CDD:238001	29/115 (25%)
		CCP	834..891	CDD:153056	13/75 (17%)
		CUB	895..1002	CDD:238001	27/121 (22%)
		CCP	1010..1063	CDD:214478	7/57 (12%)
		CUB	1067..1175	CDD:238001	25/117 (21%)
		CCP	1182..1238	CDD:153056
		CUB	1241..1348	CDD:238001
		CCP	1354..1411	CDD:153056
		CUB	1414..1522	CDD:238001
		CCP	1528..1585	CDD:153056
		CUB	1588..1695	CDD:238001
		Sushi	1701..1758	CDD:278512
		CUB	1762..1869	CDD:238001
		CCP	1878..1936	CDD:153056
		CUB	1939..2046	CDD:238001
		CCP	2052..2107	CDD:153056
		CUB	2111..2218	CDD:238001
		CCP	2224..2280	CDD:153056
		CUB	2283..2389	CDD:238001
		CCP	2395..2453	CDD:153056
		CUB	2460..2566	CDD:238001
		CCP	2569..2628	CDD:153056
		PHA02927	2627..2871	CDD:222943
		Sushi	2632..2689	CDD:278512
		CCP	2694..2755	CDD:153056
		PHA02927	2756..2991	CDD:222943
		CCP	2759..2812	CDD:153056
		CCP	2817..2871	CDD:153056
		CCP	2875..2929	CDD:153056
		PHA02927	2928..3168	CDD:222943
		CCP	2933..2991	CDD:153056
		CCP	2995..3048	CDD:153056
		CCP	3056..3110	CDD:153056
		CCP	3114..3168	CDD:153056
		PHA02927	3168..3407	CDD:222943
		CCP	3173..3229	CDD:153056
		Sushi	3233..3286	CDD:278512
		CCP	3291..3345	CDD:153056
		CCP	3352..3407	CDD:153056
		CCP	3411..3467	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910