Protein Alignment STX19 and Syx4

DIOPT Version :10

• Sequence 1: NP_001001850.1
• Gene: STX19 / 415117
• HGNCID: 19300
• Length: 294
• Species: Homo sapiens
• Sequence 2: NP_525057.2
• Gene: Syx4 / 31269
• FlyBaseID: FBgn0024980
• Length: 333
• Species: Drosophila melanogaster
• Alignment Length: 321
• Identity: 58/321 - (18%)
• Similarity: 132/321 - (41%)
• Gaps: 61/321 - (19%)

Human     2 KDRLQELKQRTKEIE-----------------------------------LSRDSHV-----STT 26
            ||||.||.||:....                                   :|::||.     |:|
  Fly     3 KDRLPELLQRSLSTNSSNSSSNGSLLLNVYSGTTEFIIGNTGGNNNSYSVVSQNSHSCSNNNSST 67

Human    27 ETEEQGVFLQQAVIYEREPVAERHLHEIQKLQESINNLADNVQKFGQQQKSLVASMRRFSLLKRE 91
            |.:::    ..:.:.:.....:..|:...::::.:..:|.|::...:..:::  ::|.|:..:.:
  Fly    68 EPKDR----SSSKMTQYGSNVDDILNPYTEIRQQLAQIAANLETMNRMAQTV--NLRTFNENEMD 126

Human    92 STITKEIKIQAEYINRSLNDLVKEVKKSEVENGPSSVVTRILKSQHAAMFRHFQQI-----MFIY 151
            ....|.:::..:.:.| .||.    |.:.......|:..|:.::....:.:.|..:     :|:.
  Fly   127 ELHNKNLRLGNQLMTR-FNDF----KANLPAENDYSLEARMKRTLFYGLHQTFINLWHKNELFLQ 186

Human   152 NDTIAAKQEKCKTFILRQLEVAGKEMSEEDVNDMLHQGKWEVFNESLLTEINITKAQLSEIEQRH 216
            |     .:.|.|..:....::...|.||:::..::.....::|.::.|.|....:..|.|:..|.
  Fly   187 N-----YETKVKKNLRLHTKIINSEASEQEIELLIENKTTKLFVDNFLQETEKERQTLREMMDRF 246

Human   217 KELVNLENQIKDLRDLFIQISLLVEEQGESINNIEMTVNSTKEYVNNTKEKFGLAVKYKKR 277
            .||..||..|:::..||::|..||.||.|.|..:|........:|:...::...|.:::|:
  Fly   247 NELRRLEKSIEEVHALFMRIQTLVMEQSEVIQRVEFHAQQATLHVDKGADELDQAEQHQKK 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STX19	NP_001001850.1	Syntaxin	49..244	CDD:459942	37/199 (19%)
		SNARE	212..278	CDD:473982	19/66 (29%)
Syx4	NP_525057.2	COG5074	<187..313	CDD:227406	30/126 (24%)
		SNARE_syntaxin1-like	238..298	CDD:277201	19/59 (32%)