Protein Alignment ARSL and Sgsh

DIOPT Version :9

• Sequence 1: NP_001269557.1
• Gene: ARSL / 415
• HGNCID: 719
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_650760.1
• Gene: Sgsh / 42266
• FlyBaseID: FBgn0038660
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 644
• Identity: 140/644 - (21%)
• Similarity: 223/644 - (34%)
• Gaps: 221/644 - (34%)

Human    36 FRSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVK 100
            |..||.|              ..||...|:|||:|||.|. :.|.|.|...:|||:|.||:.|:.
  Fly     8 FTLWLIA--------------GCSAGPQNVLLLLADDAGF-ESGAYLNKFCQTPNLDALAKRGLL 57

Human   101 LTQHISAASLCTPSRAAFLTGRYPVRSGMV----SSIGYRVLQWTGASGGLPT--NETTFAKILK 159
            .....::.|.|:|||:..|||:....|||.    ....:.||..||:   ||.  .:.:..:||
  Fly    58 FNNAFTSVSSCSPSRSQLLTGQAGHSSGMYGLHQGVHNFNVLPDTGS---LPNLIRDQSGGRIL- 118

Human   160 EKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNF 224
                 :|:|||.|:|.......|.......|..:.. |...:.|.:.||..|.:.:   ::|..|
  Fly   119 -----SGIIGKKHVGAANNFRFDFEQTEEQHSINQI-GRNITRMKEYARQFLKQAK---DEKKPF 174

Human   225 LFQVLALVALTLVAG-----KLTHLIP-------------------VSWMPVI--WSALSAVLLL 263
            .          |:.|     :..|:.|                   ..|.|:.  |..|.....|
  Fly   175 F----------LMVGFHDPHRCGHITPQFGEFCERWGSGEEGMGSIPDWKPIYYDWRNLDVPAWL 229

Human   264 ASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIP 328
            ..                               |.::.||:|:
  Fly   230 PD-------------------------------TDVVRQELAA---------------------- 241

Human   329 LITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYG 393
                 .::          .:..:|..||.:|..|:..|:::.||:.:|||:|....        |
  Fly   242 -----QYM----------TISRLDQGVGLMLKELEAAGVADQTLVIYTSDNGPPFP--------G 283

Human   394 GWNGIYKGGKGMGGWEGGIRVPGIFRWPG------VLPAGRVIGEPTSLMDVFPTVVRLAGGEVP 452
            |...:|         |.|||.|.|...|.      ...|..|     ||:|::|:|:.......|
  Fly   284 GRTNLY---------EHGIRSPLIISSPNKEDRHHEATAAMV-----SLLDIYPSVMDALQIPRP 334

Human   453 QDRVIDGQDLLPLL------------LGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMW----- 500
            .|..|.|:.:||:|            .|:  ||.||..|.|..|.:...|:........|
  Fly   335 NDTKIVGRSILPVLREEPPIKESDSVFGS--HSYHEVTMAYPMRMVRNRRYKLIHNINYWADFPI 397

Human   501 -KVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPP--LLFDLSRDPSETHILTPASEPVFYQV 562
             :..:.:|.|| :...|...::..|.:...:.::..|  .|:|:..||.|...|  |.:..:...
  Fly   398 DQDFYTSPTFQ-QILNATLRKQTLPWYRSLLQYYQRPEWELYDIKTDPLERFNL--ADKAKYNGT 459

Human   563 MERVQQAVWEHQ-RTLSPVPLQLDRLGNIWRPWLQPCCGPF------------PLCWCL 608
            ::::::.:::.| .|..|           ||      |.|.            |:|..|
  Fly   460 LKQLREQLFDWQVATKDP-----------WR------CAPHAVLQEQGVYKDQPVCLTL 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARSL	NP_001269557.1	ALP_like	62..585	CDD:355016	127/581 (22%)
Sgsh	NP_650760.1	AslA	17..476	CDD:225661	128/577 (22%)
		SGSH	22..471	CDD:293751	124/567 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810