DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and MBD2

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_003918.1	Gene:	MBD2 / 8932	HGNCID:	6917	Length:	411	Species:	Homo sapiens

Alignment Length:	215	Identity:	52/215 - (24%)
Similarity:	71/215 - (33%)	Gaps:	62/215 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 GSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLI 439
            |..||.||..|      ||:|...|.                              |.|:.|
Human   110 GCGGGGSGGGG------APRREPVPF------------------------------PSGSAG--- 135

  Fly   440 VGEHQKPTVIVQDWR-----LPPGWIKHMYQRSNVL--GKWDVILVSPSGKRFRSKSDLKLFLES 497
             ...:.|.......|     |||||.|....|.:.|  ||.||...|||||:||||..|..:|.:
Human   136 -PGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGN 199

  Fly   498 QNLVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDVSMNSTL---------DQSITS 553
               ..:...:||...:.....:.........:|....|.:|   .:|:||         .|.:|.
Human   200 ---TVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKP---DLNTTLPIRQTASIFKQPVTK 258

  Fly   554 QHSLPSTPMPVKESQYMEAP 573
            ..:.||..:.....:..|.|
Human   259 VTNHPSNKVKSDPQRMNEQP 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690	26/79 (33%)
		PHD_SF	919..963	CDD:304600
MBD2	NP_003918.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..158		17/87 (20%)
		Necessary for interaction with DHX9. /evidence=ECO:0000269\|PubMed:12665568	1..149		14/78 (18%)
		MeCP2_MBD	151..214	CDD:238690	25/65 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..241		3/29 (10%)
		MBDa	226..292	CDD:406868	12/56 (21%)
		MBD_C	297..387	CDD:404858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900