DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and SET1

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_011987.1	Gene:	SET1 / 856519	SGDID:	S000001161	Length:	1080	Species:	Saccharomyces cerevisiae

Alignment Length:	701	Identity:	127/701 - (18%)
Similarity:	234/701 - (33%)	Gaps:	234/701 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 IVAQILSESAERKATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVAASSEATVPAPGSAS 196
            |:..|:|:..|....   |..|..:::|...|  ::|....|||..|..:....|..|.....:|
Yeast   342 ILNNIISKFVEINVK---KLQKLQENLKKAKE--KEAENEKAKELQGKDITLPKEPKVDTLSHSS 401

  Fly   197 SSNSPLP-------GTPP-------------------KY-------------------------- 209
            .|...:|       ...|                   ||
Yeast   402 GSEKRIPYDLLGVVNNRPVLHVSKIFVAKHRFCVEDFKYKLRGYRCAKFIDHPTGIYIIFNDIAH 466

  Fly   210 ----SNPH--NLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEW 268
                ||..  ||||.:|            :|.:.:......:|.||:...:...|.|:|.|....
Yeast   467 AQTCSNAESGNLTIMSR------------SRRIPILIKFHLILPRFQNRTRFNKSSSSSNSTNVP 519

  Fly   269 MAIKS-ERLRQRLSNRVLPVFE----LDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKN 328
            :..:| |...:..:.::|...|    :|.|               ::|:|...::.|
Yeast   520 IKYESKEEFIEATAKQILKDLEKTLHVDIK---------------KRLIGPTVFDAL-------- 561

  Fly   329 VRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRAST------GSLGGSSGSSGSK 387
               .|.| .|:.|...::.|:   :....:.:.::...:..|..:.      |..||.:.|:
Yeast   562 ---DHAN-FPELLAKRELKEK---EKRQQIASKIAEDELKRKEEAKRDFDLFGLYGGYAKSN--- 616

  Fly   388 KSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQ-------PIGTEGFLIVG-EHQ 444
                   :|:....:..:||..||...::.:..:...|.:|::       |:..||...|. ||.
Yeast   617 -------KRNLKRHNSLALDHTSLKRKKLSNGIKPMAHLLNEETDSKETTPLNDEGITRVSKEHD 674

  Fly   445 KPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSG---------KRFRSKSD---------- 490
            :.                           |..:.|.|.         |:|:|:|:
Yeast   675 EE---------------------------DENMTSSSSEEEEEEAPDKKFKSESEPTTPESDHLH 712

  Fly   491 -LKLFLESQNLVYNPDVYD-FSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITS 553
             :|..:..||  .:.||.| .|:::..|.:|          |:|...|...|:..:.|| .|:..
Yeast   713 GIKPLVPDQN--GSSDVLDASSMYKPTATEI----------PEPVYPPEEYDLKYSQTL-SSMDL 764

  Fly   554 QHSLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPADETKP-KIEAEILEASEGGTSQLMLAD 617
            |:::..     :|...:...:.|...|.  ::|:|..|.|.|. :...::||..:....|:.|
Yeast   765 QNAIKD-----EEDMLILKQLLSTYTPT--VTPETSAALEYKIWQSRRKVLEEEKASDWQIEL-- 820

  Fly   618 PHVVENGFAFIGGLKV----------KIQDNLYV--CPREDCAKTYRKEDFLLIHIRHYHKEFAE 670
                 ||..|...|:.          ||.|.|.:  .|       :|:.....::..:.|.|..|
Yeast   821 -----NGTLFDSELQPGSSFKAEGFRKIADKLKINYLP-------HRRRVHQPLNTVNIHNERNE 873

  Fly   671 HVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRS 721
            :.....:.:|.:.|....|...:|.:...|:..|::|     |||::..::
Yeast   874 YTPELCQREESSNKEPSDSVPQEVSSSRDNRASNRRF-----QQDIEAQKA 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	4/36 (11%)
		MeCP2_MBD	449..522	CDD:238690	16/93 (17%)
		PHD_SF	919..963	CDD:304600
SET1	NP_011987.1	RRM_scSet1p_like	246..360	CDD:409743	5/20 (25%)
		SET_assoc	422..486	CDD:403081	9/75 (12%)
		SET	612..1080	CDD:225491	73/384 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030