DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and CTI6

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_015144.1	Gene:	CTI6 / 855920	SGDID:	S000006102	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	394	Identity:	86/394 - (21%)
Similarity:	139/394 - (35%)	Gaps:	119/394 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   868 DSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEE-IINCICEYGEED--- 928
            |.:||.|:...|   ||:.....|:: |......|.||    ..:.:|| ...|||  ||.|
Yeast    30 DIISTTSTATTT---AAIGSVQEESV-KQEDVPMEGGE----GEVEEEEGETRCIC--GELDTPD 84

  Fly   929 --GLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICR-------NPQRGRDSMRFKHDQDWLFE 984
              |..||||.|..||||.|..|.:: :.||||.|..||       ....|.....:|..|:...:
Yeast    85 DSGFFIQCEQCSSWQHGYCVSITQD-NAPDKYWCEQCRPELHQLFTTDTGEARSIYKPVQEKRRQ 148

  Fly   985 GK-----LPVAAYHTAN-----PQATKQFE---------------------LLKRSHTLTG---- 1014
            .:     ...:..|.||     |:.|...:                     |.|..:|.:.
Yeast   149 SRRKARSAAASKSHAANEAEKSPRNTSNTDDNVDDIGDEEDEVEDEASAVALAKDGNTRSSRRRR 213

  Fly  1015 ---------------------NLLDAKRS---------MHSLLVK-INIARNRCH---PKLY--- 1042
                                 .|||.||:         ...:|.| :..:|...|   |:.|
Yeast   214 RNSMDDASTDQYSLDPGDSDKKLLDRKRATFMAREEKQYQRMLEKALKESRRTSHQEDPESYEND 278

  Fly  1043 --LWAKKWDEDNLDSTALTPVKRAKLEAPDLPNVPQPEAAIDPEECQYRLIEHIKVQQSLVLDRL 1105
              ::  :.|.||.:.|       .:|:...:....:|::..:.:     :.|.::..:...:::.
Yeast   279 ADIY--QGDTDNHNGT-------TRLQTDVMLTEGKPDSVTNDD-----MKESLRPSKEQSMEKT 329

  Fly  1106 NDIEAEMDELEKEDTLDDLKDADISTTKEALATFIKELETMKRLA------KLNQVANMKQTLRD 1164
            ||:|.|..: |||.:....:|.:.:.......|.|...|...|.|      ::::.|......|.
Yeast   330 NDVEKEASQ-EKESSTGSAQDTEKTDEPILPLTSISSSEDDSRKASSRGSKRVSKPARKGNRTRR 393

  Fly  1165 SATS 1168
            |.||
Yeast   394 SNTS 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600	23/48 (48%)
CTI6	NP_015144.1	PHD_MLL5	74..120	CDD:277025	23/48 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930