DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and SET2

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_012367.2	Gene:	SET2 / 853271	SGDID:	S000003704	Length:	733	Species:	Saccharomyces cerevisiae

Alignment Length:	738	Identity:	137/738 - (18%)
Similarity:	245/738 - (33%)	Gaps:	213/738 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 RHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDTAEIEADQRALQHASVEGTTETPGNAQSSTND 122
            |||:...|..::||:::                            .|:::|:.....|...|.|.
Yeast   169 RHFKHFYFMMLQNGEFI----------------------------DATIKGSLARFCNHSCSPNA 205

  Fly   123 DVIKATV-DQIVAQILSESAERKATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVAASSE 186
            .|.|..| |::...|.   |:||..:    |:......|....|..|.|...:||:.........
Yeast   206 YVNKWVVKDKLRMGIF---AQRKILK----GEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKT 263

  Fly   187 ATVPAPGSASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPAR------IVEVNETEQTL 245
            .|     .|:|.      .|...::...:|:       |:|..||..:      |:: ||.|.
Yeast   264 QT-----DAASL------LPQNIADALGVTV-------SMEKKWLKLKKLSGEPIIK-NENEN-- 307

  Fly   246 LVRFERNHKLKVSPSTSG-SFQEWMAIKSERLRQRLSNRVLP-VFELDEKCM----ARWSGPRKF 304
             :..|....|:|.|..|. ...:.|::..::..:.:::::|. :|.:|:..:    .:..|...|
Yeast   308 -INIEFLQSLEVQPIDSPVDVTKIMSVLLQQDNKIIASKLLKRLFTIDDDSLRHQAIKLHGYTCF 371

  Fly   305 PGTIRKLL---------GNDTYEVLFDDGYVKNVRAV--HMNKMPKQLPPVQVAEEGASKSPTPV 358
            ...::..:         ||:|.|   ||  :|.::.:  .:.::||      ....|...|  .:
Yeast   372 SKMLKLFITEQPQVDGKGNETEE---DD--IKFIKGILDFLLELPK------TTRNGIESS--QI 423

  Fly   359 GTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWT 423
            ...|.:.|     |....|..:......|.||....:|    :....:::|:
Yeast   424 DNVVKTLP-----AKFPFLKPNCDELLEKWSKFETYKR----ITKKDINVAA------------- 466

  Fly   424 CHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGW-IKH-----MYQRSNVLGKWDVILVSPSG 482
                                 ...:.::..|||||| |.|     :|..:....|   :...|||
Yeast   467 ---------------------SKMIDLRRVRLPPGWEIIHENGRPLYYNAEQKTK---LHYPPSG 507

  Fly   483 --KRFRSKSDLKL-FLESQNLVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDVSMN 544
              |.|.|:|:.:: ...|..:...|...|...|:...::...            .|.:.::.. .
Yeast   508 SSKVFSSRSNTQVNSPSSSGIPKTPGALDSKKHKLSDEEYER------------KKQKRLEYE-R 559

  Fly   545 STLDQSITSQHSLPSTPMPVK----ESQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEA 605
            ..|:::  .|..|.|....:|    ....:|..:|......||...:.:...|.|   ||:.|:.
Yeast   560 IALERA--KQEELESLKQKLKLENERKSVLEDIIAEANKQKELQKEEAKKLVEAK---EAKRLKR 619

  Fly   606 SEGGTSQLMLADPHVVENGFA-FIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEF- 668
            .....||.:   .|.....|| |:..|   |:.|    |:.                    |:|
Yeast   620 KTVSQSQRL---EHNWNKFFASFVPNL---IKKN----PQS--------------------KQFD 654

  Fly   669 AEHVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATS 733
            .|::..|.| ..:.:..|.....|...|.|.:....::...|............|::...|.|.|
Yeast   655 HENIKQCAK-DIVKILTTKELKKDSSRAPPDDLTKGKRHKVKEFINSYMDKIILKKKQKKALALS 718

  Fly   734 STPSDITPTKALLSPKMEPPSVS 756
            |..:.::      ||   |||.|
Yeast   719 SASTRMS------SP---PPSTS 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	6/27 (22%)
		TUDOR	292..329	CDD:119391	9/49 (18%)
		MeCP2_MBD	449..522	CDD:238690	21/81 (26%)
		PHD_SF	919..963	CDD:304600
SET2	NP_012367.2	AWS	64..119	CDD:197795
		SET_SETD2	119..260	CDD:380949	26/125 (21%)
		SET	215..695	CDD:225491	110/616 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030