Protein Alignment MBD-R2 and PHF23

DIOPT Version :10

• Sequence 1: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: XP_024306706.1
• Gene: PHF23 / 79142
• HGNCID: 28428
• Length: 407
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 98/477 - (20%)
• Similarity: 150/477 - (31%)
• Gaps: 175/477 - (36%)

  Fly   576 SLMPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLMLADPHVVENGF-----AFIGGLKVKI 635
            :|.||..| .|:|||.::.:..||.                     .|.|     |:.|
Human    14 TLDPPPTL-KPETQPPEKRRRTIED---------------------FNKFCSFVLAYAG------ 50

  Fly   636 QDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPKN 700
                |:.|.::                  ..::....|..|...|.|      :..|..::.|.:
Human    51 ----YIPPSKE------------------ESDWPASGSSSPLRGESA------ADSDGWDSAPSD 87

  Fly   701 QIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDIT------PTKALLSPKMEPPSVSPTV 759
            ....|.|        :::::|.||::..|..|...|...|      |..|.|..||:
Human    88 LRTIQTF--------VKKAKSSKRRAAQAGPTQPGPPRSTFSRLQAPDSATLLEKMK-------- 136

  Fly   760 ESGIKQEDVSLDAGP--TQSFNP-SLSRSCK-RARLSPSKRPSGS-----RKSNRQRSQRRPILS 815
               :|.....|| ||  ....:| ||:.:.: .|.|:|.....|.     ||.:|:..:..|
Human   137 ---LKDSLFDLD-GPKVASPLSPTSLTHTSRPPAALTPVPLSQGDLSHPPRKKDRKNRKLGP--- 194

  Fly   816 DNPAGHGLTEQDVEETRQSFNTPTPD-----TRIDSKKRRS-------------GAATTPISSID 862
            ...||.|:..:.         .|||.     :||...|:|.             |....|.|..|
Human   195 GAGAGFGVLRRP---------RPTPGDGEKRSRIKKSKKRKLKKAERGDRLPPPGPPQAPPSDTD 250

  Fly   863 SPAMGDSVSTPSSNDQTDINAALAP----------------------PPAETLSKA--------- 896
            |....:........:...:....||                      |||::.||.
Human   251 SEEEEEEEEEEEEEEMATVVGGEAPVPVLPTPPEAPRPPATVHPEGVPPADSESKEVGSTETSQD 315

  Fly   897 PQYIKENGELIRIVRMRQEEI-----------INCICEYGEEDGLMIQCELCLCWQHGACNGIVK 950
            .......||:    |:..|:|           |.|.|........||:|.||..|.|.:| ..:|
Human   316 GDASSSEGEM----RVMDEDIMVESGDDSWDLITCYCRKPFAGRPMIECSLCGTWIHLSC-AKIK 375

  Fly   951 EADVPDKYVCYICR--NPQRGR 970
            :.:|||.:.|..|:  .|:..|
Human   376 KTNVPDFFYCQKCKELRPEARR 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	5..84	CDD:461662
		MBT_PHF20L1-like	215..282	CDD:439094
		Tudor_PHF20-like	288..337	CDD:410457
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:473978	15/43 (35%)
		PRK04778	<1099..>1153	CDD:179877
PHF23	XP_024306706.1	PHD_PHF23	345..388	CDD:277101	15/43 (35%)