DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and Phf23

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_006534564.1	Gene:	Phf23 / 78246	MGIID:	1925496	Length:	431	Species:	Mus musculus

Alignment Length:	466	Identity:	91/466 - (19%)
Similarity:	150/466 - (32%)	Gaps:	155/466 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 SLMPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLMLADPHVVENGF-----AFIGGLKVKI 635
            ||.||..| .|:|||.::.:..||.                     .|.|     |:.|
Mouse    40 SLYPPPTL-KPETQPPEKRRRTIED---------------------FNKFCSFVLAYAG------ 76

  Fly   636 QDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPKN 700
                |:.|.::                  ..::....|..|...|.|      :..|..::.|.:
Mouse    77 ----YIPPSKE------------------ESDWPASGSSSPLRGESA------ADSDGWDSAPSD 113

  Fly   701 QIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQ 765
            ....|.|        :::::|.||::|     .|.|:...|.::..|....|.|.:...:..:|.
Mouse   114 LRTIQTF--------VKKAKSSKRRAV-----QSGPTQPGPPRSTFSRLQAPDSATLLEKMKLKD 165

  Fly   766 EDVSLDAGP--TQSFNP-SLSRSCK-RARLSPSKRPSGSRKSNRQRSQR-RPILSDNPAGHGLTE 825
            ....|| ||  ....:| ||:.:.: .|.|:|.....|.....|::.:: |.:.....||.|:..
Mouse   166 SLFDLD-GPKVASPLSPTSLTHTSRPPAALAPVPLSQGDLSQPRKKDRKNRKLGPGGGAGFGVLR 229

  Fly   826 QDVEETRQSFNTPTPD-----TRIDSKKRRS-------------GAATTPISSIDSPAMGDSVST 872
            :.         .|.|.     :||...|:|.             |....|.|..||....:....
Mouse   230 RP---------RPAPGDGEKRSRIKKSKKRKLKKADRGDRLPPPGPPRAPPSDTDSEEEEEEEEE 285

  Fly   873 PSSNDQTDINAALAPPPAETLSKAPQ------------------------------YIKENGELI 907
            ....::..:...:..|...|..:||:                              .....||:
Mouse   286 EDDEEEMTVGGGVPAPVLPTPPEAPRPPVTVHSEGAPPTDSEGKDVGSTETSQDGDASSSEGEM- 349

  Fly   908 RIVRMRQEEI-----------INCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCY 961
               |:..|:|           |.|.|........||:|.||..|.|.:| ..:|:.:|||.:.|.
Mouse   350 ---RVMDEDIMVESGDDSWDLITCYCRKPFAGRPMIECSLCGTWIHLSC-AKIKKTNVPDFFYCQ 410

  Fly   962 ICR--NPQRGR 970
            .|:  .|:..|
Mouse   411 KCKELRPEARR 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600	15/43 (35%)
Phf23	XP_006534564.1	PHD_PHF23	369..412	CDD:277101	15/43 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900