DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and kmt2e

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_004913074.2	Gene:	kmt2e / 779539	XenbaseID:	XB-GENE-976589	Length:	1800	Species:	Xenopus tropicalis

Alignment Length:	1228	Identity:	234/1228 - (19%)
Similarity:	392/1228 - (31%)	Gaps:	330/1228 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PIIRAIWIKNSRI-SLERQITKSVLVC---SRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDT 91
            |.:.:...||.:| ...:.:....|:.   .:...|..|..  ||.:..:|  :|.:..:.|...
Frog   345 PPVESYLQKNKKILKAAKDLLPETLIIEYRGKFMLREQFEA--NGYFFKRP--YPFILFYSKFHG 405

  Fly    92 AEIEADQRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQILSESAE-RKATEEGKTGKAA 155
            .|:..|.|            |.||..             :.:.:..:.:|| |...|||......
Frog   406 LEMCVDAR------------TFGNEA-------------RFIRRSCTPNAEVRHVIEEGTIHLYI 445

  Fly   156 DDVKNTPESGE--------------DANKAAAKEPSGTPVAASSEATVPAPGSASSSNSPLPGTP 206
            ..:.:.|:..|              ..:.|..|:....||...|  |.|...::........|..
Frog   446 YSISSIPKGAEITIAFDFDYANCKYKVDCACFKDNPDCPVLRCS--TEPTENNSGYETRRKKGKK 508

  Fly   207 PK------YSNPHNLTI---GARLEALSVEGN----WLPARIVEVNETEQTLLVRFERNHKLKVS 258
            .|      .|...|:.|   || :.......|    ..|.|:...|..|..:....|.|..|  |
Frog   509 EKELLKERESQNQNIVIDSDGA-INKFKTSDNKQRKLSPLRLSISNNQEPDINDDIEENTPL--S 570

  Fly   259 PSTSGSFQEWMAIKSERL--RQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLF 321
            .......:|.:|.:..::  .:|....:|..|...||...|.....:..||.:..:..::
Frog   571 NDVEMETEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQALERIGTSKPDVKTES----- 630

  Fly   322 DDGYVKNVRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGS 386
                 |:::.:    ...:|||..|.||.||| |||.....:....:..|:.|..  |.......
Frog   631 -----KDLQII----SELELPPEPVKEEPASK-PTPAKINRTKQRKSFTRSRTHI--GQQRRRHR 683

  Fly   387 KKSKCAPQRRDWPLLDMA--SLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFL----------- 438
            ..|.|:..:...|.:::.  .::..:..:||.| ..|.:.|...:.| .||..:
Frog   684 TISTCSDIQPSSPDVEVVPQQIETENNAVPEEP-PNESSPHNTEEVP-ETESCVQSKCSIKYPKT 746

  Fly   439 ---IVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQN- 499
               :|.|                |:...::::...|  :.||..|    .|..:|.::.....|
Frog   747 KKHLVNE----------------WLNEKHEKAGKPG--EPILERP----LRITTDPEVLATQLNS 789

  Fly   500 ---LVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDVS---MNSTLDQSITSQHSLP 558
               |:|:|.||....|..|        :|..:..:...|....:||   ....|.:::..::|..
Frog   790 LPGLMYSPHVYTTPKHYIR--------FTSPFLSEKKKKKNEENVSSCCKKRWLKKALEEENSSG 846

  Fly   559 STPMPVKESQYMEAPVASLMPPAELMSPQTQP-ADETKPKIEAEIL-----EASEGGTSQLMLAD 617
            ..|.........::||:.......|:...:.| ||.|.|..:..:.     ..||..|.   :|.
Frog   847 VNPFGSPAQDRSQSPVSLHENKCHLIMNGSSPLADFTTPLKKRRLFNFLDCNFSESSTP---VAS 908

  Fly   618 PHVVE--------NGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSH 674
            |:...        :...|....:||:::.  :| |..|.:||..               ...|:.
Frog   909 PYATPTHTDITSMDTSLFTTPPRVKVEEE--IC-RNGCKQTYSP---------------VTPVTP 955

  Fly   675 CPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAK-----------------MHQQDLQQSRSF 722
            |     |.....|..||...::.|:   .|::.|.:                 :....||:.::|
Frog   956 C-----LRGNNMHFESISSPDSSPE---VNRRSFCQEGNDRASTALNSFRNTSLSDMGLQEIKTF 1012

  Fly   723 ------KRQSVS--------ATATSSTPSDITPTKALLSPKMEPP-------SVSPTVESGIKQE 766
                  .|..||        |.:.....:||....: |...||||       |:..|..||....
Frog  1013 GYCSPRNRTDVSGQCPGENDAASEVHFGADINEHSS-LQKVMEPPQDRTDLNSLQETALSGQGTM 1076

  Fly   767 DVSLDAGPTQSFNPSLSRSCKRARLSPSKR--PSGSRKSNRQR----SQRRPILSDNPAGHGLTE 825
            ..:....|.::....||.:.....|:||.:  ..|..:.|..:    ...|.:..|.|......|
Frog  1077 YSTWIKSPNRTGVNFLSMNSNLRDLTPSHQLEVGGGFRMNESKCLIPEDSRGVFIDGPIFCSAEE 1141

  Fly   826 QDVEETRQSF-------NTPTPDTRIDSKK-------------RRSGAATTPISSIDSPAMGDSV 870
            ..|....:|.       ...||......||             |:||:....:|.:......|.:
Frog  1142 GTVSGFGRSLGGDGILDGNGTPLNPPQKKKVSLLEYRKRQKEARKSGSKQENLSLVTLSPHPDGI 1206

  Fly   871 --STPSSN--------DQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYG 925
              .|||.:        ||.|.:..|..|..                ::.|...:.|..:.:.:..
Frog  1207 VNCTPSESCSAVAECIDQNDASTCLTQPSE----------------VQSVPSEETEQTSSVTDTS 1255

  Fly   926 --EEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQRG---RDSMRFKHDQDWLFEG 985
              |::...:|      |....|...|:|            |:.||.   .|..:.|.|.|  .||
Frog  1256 STEKNDPEVQ------WTASTCVEQVRE------------RSYQRALLLSDHRKDKDDAD--IEG 1300

  Fly   986 KLP----------VAAYHTANPQATKQFELLKR-SHTLTGNLLD-AKRSM--HSLLVKINIARNR 1036
            ..|          :::.:..:|:.:|...|:.. ||..|.:.|| |:.:|  .|....:|.....
Frog  1301 GDPANAKECQSPDISSKNCRSPKQSKPCSLVPNLSHGKTPSKLDPAQETMVNPSTTADVNFCNTD 1365

  Fly  1037 CHPKLYL------WAKKWDEDNLDSTALTPVKRAKLEAPDLPNVPQPEAAIDPEECQY 1088
            ...|..|      .|:|     |.||.|      ||..|..|.:..|..:..|.:..|
Frog  1366 SQQKQLLSKSLIPHAQK-----LPSTPL------KLHCPSSPLLEHPPKSSTPVQHGY 1412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	11/58 (19%)
		TUDOR	292..329	CDD:119391	6/36 (17%)
		MeCP2_MBD	449..522	CDD:238690	15/76 (20%)
		PHD_SF	919..963	CDD:304600	6/45 (13%)
kmt2e	XP_004913074.2	PHD_MLL5	118..161	CDD:277025
kmt2e	XP_004913074.2	SET_KMT2E	338..466	CDD:380959	26/149 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030