DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and NSD2

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001035889.1	Gene:	NSD2 / 7468	HGNCID:	12766	Length:	1365	Species:	Homo sapiens

Alignment Length:	849	Identity:	161/849 - (18%)
Similarity:	269/849 - (31%)	Gaps:	285/849 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 KLKVSPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELDEKC-----MARWSGPRKFPGTIRKLLG 313
            |:|.:|...||                :|...|..|::.:|     .|:.|...: .|.::|..|
Human    20 KMKQAPEILGS----------------ANGKTPSCEVNRECSVFLSKAQLSSSLQ-EGVMQKFNG 67

  Fly   314 NDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQVAEEGA--------SKSPTPVGTPVSSAPV--- 367
            :|....:..|            |:......|...|.||        |:....:|||.::.|:
Human    68 HDALPFIPAD------------KLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNG 120

  Fly   368 AP-------------KRASTGSLGGSSGS-------SGSKKSKCAPQRRDW-----PLLDMASLD 407
            :|             |.....|:.|.|.:       :|.|....|.:.|..     .||:...::
Human   121 SPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVE 185

  Fly   408 IASLGLPEIPHDGE------------------------------------WTCHWVNDQPIGTEG 436
            .|.:.....|.|.:                                    |.| .|:..|:....
Human   186 AALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPC-MVSADPLLHSY 249

  Fly   437 FLIVGEHQKPTVI-VQDWRLPP--GWIKHMYQRSNVL----GKWDVILVSPSGKRFRSKSD-LKL 493
            ..:.|:.:..... ||.:...|  .||   :::|.|.    |:::. |...|.|:..:|:: :||
Human   250 TKLKGQKKSARQYHVQFFGDAPERAWI---FEKSLVAFEGEGQFEK-LCQESAKQAPTKAEKIKL 310

  Fly   494 F------LESQ---NLVYNPDVYDFSIHRRRAKDINAYV--YTHGYNPQPPPKPRPMDVSMNSTL 547
            .      |.:|   .:|...:....|:..|:||....||  ..| .|||...:......|:....
Human   311 LKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLH-LNPQVAKEAGIAAESLGEMA 374

  Fly   548 DQSITSQHSLPSTPMPVKESQYMEAPV-----ASLMPPAELMSPQTQPADETKPKIEAEILEASE 607
            :.|..|:.: ...|..|:|..   .|:     |.|...||.:.........| |:..||
Human   375 ESSGVSEEA-AENPKSVREEC---IPMKRRRRAKLCSSAETLESHPDIGKST-PQKTAE------ 428

  Fly   608 GGTSQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKED----FLLIHIRHYHKEF 668
                    |||   ..|.....|.|    ......||.      ||.|    ||:...:|..:..
Human   429 --------ADP---RRGVGSPPGRK----KTTVSMPRS------RKGDAASQFLVFCQKHRDEVV 472

  Fly   669 AEHVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIP----------NQQFFAKMHQQDLQQSRSFK 723
            |||..               :|.:::|.:.::|..          |.:|......|..:.|.:..
Human   473 AEHPD---------------ASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVN 522

  Fly   724 RQSVSAT-----ATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFN---- 779
            .:..:.|     .|....::.||.|.|.:.|          .|..|::.::.....|.|:.
Human   523 GKKRNHTKRIQDPTEDAEAEDTPRKRLRTDK----------HSLRKRDTITDKTARTSSYKAMEA 577

  Fly   780 -PSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPIL----SDNPAGHGLTEQDVEETRQSFNTPT 839
             .||........||.:.:|  .:|.||..:.....|    |.:|:. .|||.:|.
Human   578 ASSLKSQAATKNLSDACKP--LKKRNRASTAASSALGFSKSSSPSA-SLTENEVS---------- 629

  Fly   840 PDTRIDSKKRRSGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENG 904
                                  |||....|.|...|.|:|....:::...:|
Human   630 ----------------------DSPGDEPSESPYESADETQTEVSVSSKKSE------------- 659

  Fly   905 ELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQ-HGACNGIVKEAD--------VPDKYVC 960
               |.|..::|    .:|:..|:.|.::.||...|.. |.||.|:.:..:        ....:.|
Human   660 ---RGVTAKKE----YVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSC 717

  Fly   961 YICR 964
            ::|:
Human   718 FVCK 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	8/41 (20%)
		MeCP2_MBD	449..522	CDD:238690	21/89 (24%)
		PHD_SF	919..963	CDD:304600	11/52 (21%)
NSD2	NP_001035889.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..170		3/20 (15%)
		MSH6_like	218..337	CDD:99898	22/123 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..455		24/110 (22%)
		HMG-box	458..507	CDD:238037	10/63 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..658		35/186 (19%)
		TNG2	<546..710	CDD:227367	44/228 (19%)
		PHD1_NSD1_2	669..711	CDD:277118	10/41 (24%)
		PHD2_NSD2	716..762	CDD:277121	2/6 (33%)
		PHD3_NSD2	763..816	CDD:277124
		PHD4_NSD2	833..873	CDD:277127
		WHSC1_related	878..972	CDD:99899
		AWS	1012..1062	CDD:197795
		SET	1063..1186	CDD:214614
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:27571355, ECO:0007744\|PDB:5LSU	1115..1118
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:27571355, ECO:0007744\|PDB:5LSU	1141..1142
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1207..1232
		PHD5_NSD2	1241..1283	CDD:277130
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1333..1365
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030