DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and mbd4

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001037916.1	Gene:	mbd4 / 733528	XenbaseID:	XB-GENE-489215	Length:	472	Species:	Xenopus tropicalis

Alignment Length:	389	Identity:	85/389 - (21%)
Similarity:	130/389 - (33%)	Gaps:	110/389 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 VNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSN--VLGKWDVILVSPSGKRFRSKS 489
            :.|...|.....:...:..|.||..   ||.||.:.:.||.:  ..||:||..|||.|...||:.
Frog    27 LQDSYTGASYHNVDDRNSSPDVIRS---LPHGWKRIVKQRQSGKTSGKYDVYFVSPQGTTLRSRI 88

  Fly   490 DLKLFLESQNLVYNPDV------YDFSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDVS---MNS 545
            .|..:|.:     |.::      :|||:                  |....|.|....:   .|.
Frog    89 SLAKYLNN-----NKEINLKLEDFDFSV------------------PDQSQKQRTKKETYRGRNE 130

  Fly   546 TLDQSITSQHSLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEASEGGT 610
            ..||....:::..:....||:|......:.|..                         :||:.|
Frog   131 GRDQKEAIENTQYTKETSVKKSTVCRKRIRSHR-------------------------KASDKG- 169

  Fly   611 SQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAK--TYRKEDFLLIHIRHYHKEFAEHVS 673
                            .|.|..:|.|       |:..::  |.||:. ..|..|...:|..:..|
Frog   170 ----------------IIEGRPIKRQ-------RKHSSEHLTQRKQK-KAIRSRGPKRELEQKKS 210

  Fly   674 HCPKM---QELAVKRTHPS-SIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSS 734
            ...|:   |||.|..|.|| |.|..||         :..:.:.:.|.:.|.:...|:|..|....
Frog   211 KNNKVNIQQELKVSVTAPSPSCDNEEA---------EILSTLSENDHRCSDTADDQAVPCTPELL 266

  Fly   735 TPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQ--SFNPSLSRSCKRARLSPSKR 796
            ..:.|..|.   |........:.|.|   ||.|..:.|...:  ..:|..||...:..|:|.||
Frog   267 CDAGIEETN---SDSNRDDGDTFTSE---KQTDDFITASQVEKRKTSPYFSRKAIKEALAPPKR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690	23/80 (29%)
		PHD_SF	919..963	CDD:304600
mbd4	NP_001037916.1	MeCP2_MBD	52..112	CDD:238690	22/82 (27%)
mbd4	NP_001037916.1	ENDO3c	349..>432	CDD:304925
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12098
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000