DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and Setd5

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_006506740.1	Gene:	Setd5 / 72895	MGIID:	1920145	Length:	1467	Species:	Mus musculus

Alignment Length:	965	Identity:	189/965 - (19%)
Similarity:	306/965 - (31%)	Gaps:	325/965 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PRVFPTVFPWG------KMDTAEIEADQR---------------------ALQHASVEGTTETP- 113
            |..|||:   |      |....|:|.:|:                     :.:|..|:...|.|
Mouse   454 PPSFPTI---GAETRRRKARRKELELEQQNEVPEENPDPQPQEVPEKVTVSNEHEEVDNPEEKPE 515

  Fly   114 -GNAQSSTNDDVIKA-----TVDQIVAQILS--ESAE-RKATEEGKTGKAADDVKNTPES----- 164
             ...:.:|:|....|     ..|:.|..|:.  ||.| ||...:....:::.|::.|..|
Mouse   516 EEEKEEATDDQENSAHSRRTREDRKVEAIMHAFESLEKRKKRRDQPVEQSSSDIEITTSSSEIVV 580

  Fly   165 GEDANKAAAKEPSGTPVAASSEATVPAPGSASSSNS-------------PLPGTPP-KYSNPHNL 215
            ||:...||.:....:||   |...:|:...::..|:             |:|..|| |.|.|...
Mouse   581 GEETKTAAPESEVSSPV---SNVAIPSTPQSTGVNTRRSSHAGDVAAEKPIPKPPPAKPSRPRPK 642

  Fly   216 TIGARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMAIKSERLRQRL 280
            :..:|....|.:         .:...:|.:..:.|.:   :.:....||
Mouse   643 SRISRYRTSSAQ---------RLKRQKQAIAQQAELS---QAALEEGGS---------------- 679

  Fly   281 SNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQ 345
            :|.|.|          ..:|.....|..|:|.|:|.        .|.:|...|:|:...:.|..:
Mouse   680 NNSVTP----------PEAGNTDSSGENRQLTGSDP--------TVISVTGSHVNRAASKYPKTK 726

  Fly   346 ---VAE---EGASKSPTPVGTPVSSAPVAPKRAST-----GSLGGSSGSSGSKK-----SKCAPQ 394
               |.|   :.|.|...||..|:.........|:|     |.:......:..|.     |...|:
Mouse   727 KYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFMPE 791

  Fly   395 RRDWPLLDMASLDIASLGLPEIPHDGEW-TC--HWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLP 456
            ||..|||.                ||.: :|  .|:...       |..|..|..:| .|:.|
Mouse   792 RRRRPLLP----------------DGTFSSCKKRWIKQA-------LEEGMTQTSSV-PQETR-- 830

  Fly   457 PGWIKHMYQ-----RSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNL--VYNPDVYDFSIHRR 514
               .:|:||     .|:.:.|.:..|:||. |:::|:     :|..||:  :..|
Mouse   831 ---TQHLYQSNETSNSSSICKDNADLLSPL-KKWKSR-----YLMEQNITKLLQP---------- 876

  Fly   515 RAKDINAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKES-----QYMEAPV 574
                         .:|..||.|     |..|...|..|     |....|.:|.     ..|.:|:
Mouse   877 -------------LSPVTPPPP-----SSGSKSPQLTT-----PGQTHPGEEECRNGYSLMFSPI 918

  Fly   575 ASLMPPAELMSP------QTQPADETK--------------------------------PKIEAE 601
            .||...:...:|      ..:..|.||                                |..||.
Mouse   919 TSLTTASRSNTPLQFELCHRKDLDLTKVGFPDSSTHSCADRPSLLNCNHPDLASHPSVVPTSEAG 983

  Fly   602 ILEASEGGTSQLML--------------------ADPHV--VENGFAFIGGLKVKIQDNLYVCPR 644
            ....|..|...|:.                    |.|..  :..|...:|..|....|..|..|.
Mouse   984 FPSRSGDGPQTLLRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSPA 1048

  Fly   645 EDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPK-NQIPNQQFF 708
            |..:..|                  ||    ..|::|:.....|......|.||. .|.|.|:
Mouse  1049 EGFSSRY------------------EH----GFMKDLSRGSMSPGGERTCEGVPSAPQNPPQR-- 1089

  Fly   709 AKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAG 773
               .:..|.:.|. ::|.....:.....|..:.:|:..:.:....|||.|...|::.......:.
Mouse  1090 ---KKVSLLEYRK-RKQEAKENSGGGNDSSQSKSKSSGAGQGSSNSVSDTGAHGVQGSSAGTPSS 1150

  Fly   774 PTQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFN-- 836
            |.:.|:||.|.:.....:|||  .|....|:..|.|      :|.:...:....||..|:..:
Mouse  1151 PHKKFSPSHSSASHLEAVSPS--DSRGTSSSHCRPQ------ENISSRWMVPTSVERLREGGSIP 1207

  Fly   837 ---------------TPTPDTRIDSKKR--RSGAATTPISSIDSPAMGDSVSTPS 874
                           :||.::.|..|:.  ..|....|:||  :.:.|.:|.:||
Mouse  1208 KVLRSSVRVAQKGEPSPTWESNITEKESDPADGEGPEPLSS--ALSKGATVYSPS 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	4/8 (50%)
		TUDOR	292..329	CDD:119391	7/36 (19%)
		MeCP2_MBD	449..522	CDD:238690	16/79 (20%)
		PHD_SF	919..963	CDD:304600
Setd5	XP_006506740.1	SET_SETD5	292..441	CDD:380958
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930