DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and Kmt2e

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_081260.1	Gene:	Kmt2e / 69188	MGIID:	1924825	Length:	1868	Species:	Mus musculus

Alignment Length:	1133	Identity:	224/1133 - (19%)
Similarity:	350/1133 - (30%)	Gaps:	397/1133 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SRISLERQITKSVLVCSRHFRRLDF-------------NTIRNGKYLLKPRVFPTVFPWGKMDTA 92
            :.|..:|:..::|.:||      |.             |.|.|....::|.....|        |
Mouse   659 THIGQQRRRHRTVSMCS------DIPPSSPDIEVLSQQNEIENTVLAIEPETETAV--------A 709

  Fly    93 EI--EADQRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQILSESAERKATEEGKTGKAA 155
            ||  ||:..||...    .|:.|             .|...:|.:.|||..|       ||||.:
Mouse   710 EIIPEAEVPALNKC----PTKYP-------------KTKKHLVNEWLSEKNE-------KTGKPS 750

  Fly   156 DDVKNTPESGEDANKAAAKEPSGTPVAASSEATVPAPGSASSSNSPLPG---TPPKYSNP-HNLT 216
            |.:                  |..|:..:::..|    .|:..|| |||   :|..||.| |.:.
Mouse   751 DSL------------------SERPLRITTDPEV----LATQLNS-LPGLTYSPHVYSTPKHYIR 792

  Fly   217 IGA--------RLEAL-----SVEGNWLPARIVEVNETEQTLLVRF-----ERNHKLKVSPSTSG 263
            ..:        |.|..     |.:..||...:.|.|   .|:|.|:     ||:.    ||:.:|
Mouse   793 FTSPFLSEKKRRKETTENISGSCKKRWLKQALEEEN---STILHRYHSPCQERSR----SPTVNG 850

  Fly   264 SFQEWMAIKSERLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKN 328
            .      .||..|             |.:.|        ..|.....|.....|::| |..|.::
Mouse   851 E------NKSPLL-------------LSDSC--------SLPDLTTPLKKRRLYQLL-DTAYSES 887

  Fly   329 --------VRAVHMNKMPKQ----LPP-VQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGG- 379
                    ....|.:..|..    .|| ::..:|.......|:.:||:  ||.|     |:.|.
Mouse   888 STPTPSPYATPTHTDITPTDPAFATPPRIKSDDETYRNGYKPIYSPVT--PVTP-----GTPGNT 945

  Fly   380 ------SSGSSGSKKSKCAPQRR--DWPLLDMASL------DIASLGLPEI-------------- 416
                  ||..|..:..:|...:.  |.| .:|.:|      ::..|||.||
Mouse   946 MHFENISSPESSPEIKRCTYNQEGYDRP-SNMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEV 1009

  Fly   417 --PHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQ-RSNVLGKWDVILV 478
              |..||...  |:|..:|.:........:.......|...|...:...:. |..:...|   :.
Mouse  1010 NRPCPGEKES--VSDLQLGLDAVEPAALQKSMETPAHDRTEPSNQLDSTHSGRGTMYSSW---VK 1069

  Fly   479 SP--SGKRFRSKSDLK--------------LFLESQNLVYNPDVYDFSIHRRRAKDINAYVY--- 524
            ||  :|..|...|:|:              ...||:.|:...|.        |...:.|.|:
Mouse  1070 SPDRTGVNFSVNSNLRDLTPSHQLETGGGFRVSESKCLIQQDDT--------RGMFLGAAVFCTS 1126

  Fly   525 ----THGY-------------NPQPPPKPRPMDVSMNSTLDQSITSQHSLPS-------TPMP-- 563
                ..|:             .||.||:.:.:.:.......:......|.|.       :|.|
Mouse  1127 EDGLASGFGRTVNDNLIDGSCTPQNPPQKKKVSLLEYRKRQREARKSGSKPENFALISVSPHPSG 1191

  Fly   564 ---------VKESQYMEAP--VASL-MPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLMLA 616
                     |..|:..|..  .||| :||         ||........|....:||.|:|.
Mouse  1192 SLSSSGDGCVHSSENGEQAENQASLPLPP---------PAAAAAATAAAAYSASSEEGSSN---- 1243

  Fly   617 DPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFL---------LIHIRHYHKE--FAE 670
                                     ||.:|...:.:|:..:         .:..|.|.:.  .::
Mouse  1244 -------------------------CPVKDANSSEKKDPEVQWTASTSVEQVRERSYQRALLLSD 1283

  Fly   671 HVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSF-----KRQSVSAT 730
            |........|.......||.:....:...|.||      ::|.|.|..|.|.     ..:...||
Mouse  1284 HRKDKDSGGESPCVSCSPSHVQSPPSSHSNHIP------QVHAQSLAPSLSELMADPDAEGTEAT 1342

  Fly   731 ATSSTPS-DITPTKALLSPKMEPPSVSPTVESG---------------IKQEDVSLDAGP----- 774
            :||..|| |.:.:.:..|....|..::|....|               :.:.|.|:...|
Mouse  1343 STSECPSPDTSQSPSKTSKPGSPGPINPAQSHGKILTKPDSHWEATATVSEADNSVHQNPEPQHR 1407

  Fly   775 -TQSFNPSLSRS-CKRAR-LS-----PSKRPSGSRKSN-----------RQRSQRRPI----LSD 816
             ..|..|:||:: ..:|. ||     |.|.||...|.:           :..:...|:    ||.
Mouse  1408 QLSSNTPALSQNHAPQAHALSANDQLPQKLPSAPTKLHCPPSPHTENPPKSSTPHTPVQHGYLSP 1472

  Fly   817 NPAGHGL---------------TEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAM 866
            .|....|               |.|  .||:::|.....:.:.:.::..|||..|...|
Mouse  1473 KPPSQHLGSPFRPHHSQSPQVGTPQ--RETQRNFYAAAQNLQANPQQATSGALFTQTPS------ 1529

  Fly   867 GDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLM 931
            |.|.:|.|..:|..:|:...|||.   ...|....:|          |:...| ...|.:..|.:
Mouse  1530 GQSSATYSQFNQQSLNSTAPPPPP---PPPPSSYYQN----------QQPSAN-FQNYNQLKGSL 1580

  Fly   932 IQCELCLCWQHGACNGIVKEADVPDKYV 959
            .|..:.....:.|..|...:..||..:|
Mouse  1581 SQQTVFTSGPNQALPGSTSQQSVPGHHV 1608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	11/57 (19%)
		TUDOR	292..329	CDD:119391	7/44 (16%)
		MeCP2_MBD	449..522	CDD:238690	15/89 (17%)
		PHD_SF	919..963	CDD:304600	9/41 (22%)
Kmt2e	NP_081260.1	HCFC1-binding motif (HBM). /evidence=ECO:0000250\|UniProtKB:Q8IZD2	63..66
		PHD_MLL5	120..163	CDD:277025
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..197
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..268
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..329
		SET_KMT2E	323..451	CDD:380959
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..504
		Smc	483..>716	CDD:224117	15/70 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..682		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..924		6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1038..1068		4/32 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1165..1222		12/65 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1236..1315		15/107 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1334..1565		52/251 (21%)
		Herpes_BLLF1	<1350..1609	CDD:282904	56/281 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1585..1842		5/24 (21%)
		PRK03427	<1749..>1857	CDD:235124
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930