DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and Spocd1

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_017175994.1	Gene:	Spocd1 / 622480	MGIID:	3652045	Length:	1015	Species:	Mus musculus

Alignment Length:	823	Identity:	151/823 - (18%)
Similarity:	268/823 - (32%)	Gaps:	283/823 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LLKPRVFPTVFPWGKMDTAEIEADQRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQILS 138
            |..|.::|.|.       .|...||:.:|.|.|.|:..||               .|.:..:..:
Mouse   208 LQSPALYPEVL-------TEDSTDQQEVQPAFVVGSPGTP---------------PDPVGPEDKA 250

  Fly   139 ESAERKATEEGKTGKA----------------------ADDVKNTP-----ESGEDANKAAAKE- 175
            :|..|...|:|.:..|                      ...||..|     :|.:|..:.|:|:
Mouse   251 QSGSRMELEQGLSAPANSCASSPEPLGGLDGAPLEQRRPTHVKKRPWTSPDDSSQDHAEGASKKD 315

  Fly   176 --------PSG--TPVAASSEATVPAPGSASSSNSPLPGTPPKYSNPHNL-TIGARLEALSVEGN 229
                    |.|  |.....:.:.:...|:||||.      |.:......| |..||.:......:
Mouse   316 FPRLEARVPRGVKTVYYVYTGSGIRLVGAASSSQ------PGQIEPLEELDTNSARRKRRPTTAH 374

  Fly   230 WLPARIVEVNETEQTLLVRFERNHKLKVSPSTSG--------------SFQE--W--------MA 270
            ..|.: .:.:|||..     |.:.:....|...|              :.||  |        :|
Mouse   375 PTPCQ-SDPSETENA-----EPHQQRAEDPGEQGMTPLDAGVRSTVVRAMQEVLWTRAQELPDLA 433

  Fly   271 IKSERLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGN--DTYEV-LFDDGYVKNVRAV 332
            ::.:.:..........:|.|.:....|:.  .|:    |.||.|  |...| ||       ::..
Mouse   434 LREDEVEAIAEGIEEALFHLTQDTNLRYK--NKY----RSLLFNLRDPRNVDLF-------LKVA 485

  Fly   333 HMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRD 397
            |.:..|..|  ||                :||..:|||..|              :.:...:|:.
Mouse   486 HCDVTPNNL--VQ----------------MSSIQLAPKELS--------------RWRDQEERKG 518

  Fly   398 WPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPP----- 457
            ..:::....::..|...::.|.||      .:.|...:..|.:.:..:| ::.::..|.|
Mouse   519 LDIIEQQQKELYRLPASKLTHKGE------VEIPRDLDQMLTLEDLMEP-IVPRECSLQPLSTPL 576

  Fly   458 ----GWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHRRRAKD 518
                .|.:|....||.    .:......|::....|..:|.::   :.||.|       |:.:..
Mouse   577 EDTTNWHQHHQCDSNC----QICTGGEEGRKADDGSQPELQVD---ISYNVD-------RKSSTK 627

  Fly   519 INAY---VYTHGYN-----PQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAPVA 575
            :.|:   :.....|     |.|.|...|..:.:..|                |.||      |..
Mouse   628 LPAFSGVIMNREENAIQKAPGPAPASSPEVLKVGET----------------PPKE------PQD 670

  Fly   576 SLMPPAELM-SPQTQPADETKP--------KIEAEILEASEGGTSQLMLADPHVVENG------- 624
            .|..||.|. :|.:.|..|...        :.:|:::   .|.:.||:.|.|.|:.:.
Mouse   671 RLQMPAGLKNAPPSPPPWEGSLDMFSIKHFRAKAQLI---SGHSCQLVQALPDVIRSAGRLPPSH 732

  Fly   625 ----FAFIGGLKVKIQDNLYVCPR--EDCAKTYRKEDFLLIHIRHYHKEFAEHVSHC-------- 675
                ...:|..|.|....:.:||.  .|.      :::.|::....:|:     .||
Mouse   733 VWDLLDSMGPSKAKDICVIRLCPHGSRDI------QNYRLLYSYLNNKQ-----CHCLATVQQVK 786

  Fly   676 ------PKMQEL----------AVKRTHPSSI-----------DQVEAVP-KNQIPNQQFFAKMH 712
                  |..:.|          .::.||.|.:           |...::| .|::|....|:|..
Mouse   787 MVLLPLPAFEPLPARLRPLGGPGLEITHTSLLLAVLFPKDALPDTATSIPVSNKVPKTVSFSKRV 851

  Fly   713 QQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSV 755
            ::.|     :..:...:.|||| |.:..|.::|....:.|.||
Mouse   852 ERIL-----YSPEDRRSEATSS-PLEEDPKQSLARGSLAPRSV 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	4/11 (36%)
		TUDOR	292..329	CDD:119391	10/39 (26%)
		MeCP2_MBD	449..522	CDD:238690	13/81 (16%)
		PHD_SF	919..963	CDD:304600
Spocd1	XP_017175994.1	TFIIS_M	410..520	CDD:400056	28/154 (18%)
Spocd1	XP_017175994.1	SPOC	681..825	CDD:400205	25/157 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030