DRSC/TRiP Functional Genomics Resources

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Protein Alignment MBD-R2 and nsd1b

DIOPT Version :9

Sequence 1:NP_731688.2 Gene:MBD-R2 / 41498 FlyBaseID:FBgn0038016 Length:1169 Species:Drosophila melanogaster
Sequence 2:XP_005173940.1 Gene:nsd1b / 564592 ZFINID:ZDB-GENE-080519-2 Length:1873 Species:Danio rerio


Alignment Length:1281 Identity:231/1281 - (18%)
Similarity:387/1281 - (30%) Gaps:487/1281 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 PSTSRLLEHNGVTYHSFPLDPIIRAIWIKNSRISLERQITKSVLVCSRHFRRLDFNTIRNGKYLL 75
            |::|||:..        .|..:..|.|.|.|...||   ||: .|.|.....|:.:.:.| ..||
Zfish   460 PASSRLMTR--------ALKAMEDAEWTKESSSDLE---TKN-CVSSFDSPSLETSDVHN-SILL 511

  Fly    76 KPRVFPTVFPWGKMDTA---EIEADQRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQIL 137
            :           ||.||   :::.|.:...||.:........:.:.|...:...:.|.|  |...
Zfish   512 Q-----------KMPTAAIHDLKEDSKISTHAKLSSELLCCKDDEHSVKSEDESSLVSQ--APCA 563

  Fly   138 SESAERKATEEGKTGKAADDVKNTP------------ESGEDANKAAAKEPSGTPVAASSEATVP 190
            ..|:.||....      .:|:.::|            ...|.:.|:.|.|.||.|::..      
Zfish   564 FHSSTRKQNSH------VNDLSSSPTPSLHLNLKDMDNMNEISFKSLANEHSGQPLSFH------ 616

  Fly   191 APGSASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNE--TEQTLLVRFERNH 253
                        |.:..|:|. ..:.:....::...:||.|....:...|  .|:.||:...::.
Zfish   617 ------------PDSNYKFST-FLMMLKDMHDSREKDGNVLVVEPLPTTELINEEPLLISDVKDE 668

  Fly   254 KL-----KVSPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLG 313
            |.     ||.|.|:...:..:|....:..||.|.::                      :::|   
Zfish   669 KATSKQKKVKPKTNVMSENHLASTISKTAQRSSKKI----------------------SLKK--- 708

  Fly   314 NDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLG 378
             .|.::      ..|:.....:|:                        :|:..:..|.|.|..  
Zfish   709 -KTTDI------KANIDYKSFDKL------------------------ISAHRLTSKEAETNF-- 740

  Fly   379 GSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPI----------- 432
                      |...|::| |...|..|               |.|.|.|....|           
Zfish   741 ----------SANVPKKR-WQKFDQVS---------------EKTVHIVEGNCIHKTERVSSENC 779

  Fly   433 -----GTEGFLIVGEHQKPTVI------VQDWRLPPGWIKHMYQRSNVLGKW--DVILVSPSGKR 484
                 ||......|.......:      .|:...|.. .|.:.:.|..|.:|  :...:..:.|:
Zfish   780 DVSMDGTNKSCFFGPETTSNALECNQGNCQNTEAPTE-CKRIRKPSKRLIEWTEEYDQLFSAKKK 843

  Fly   485 FRSKSDLKLFLESQ-----------NLVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQ---PPPK 535
            .:.|.|....:|:|           .:...|.|.:..:.||.              |:   |||:
Zfish   844 AKKKPDSVTKIENQKCSEPVAKTYDEVKQKPQVTEQDVSRRL--------------PELQTPPPE 894

  Fly   536 PRPMDVSMNSTLDQSITSQHSLPSTP----MPVKESQYMEAPVASLMPPAELMSPQTQPADETKP 596
                        |||       .|||    :|.:|||.:.|  .:|.||.|::   ..|.|....
Zfish   895 ------------DQS-------QSTPLINTLPCQESQVLSA--ETLTPPPEII---PSPCDNISN 935

  Fly   597 KIEAEILEASEGGTSQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHI 661
            :             .||...:|              |.:.|::       |..:           
Zfish   936 R-------------DQLQRQNP--------------VAVGDSV-------CLNS----------- 955

  Fly   662 RHYHKEFAEHVSHCPKMQELAVKRTHPSSID-QVEAVPKNQIPNQQFFAKMHQQ----DLQQSRS 721
                           |.|....|:...|||: :...:||.::.:.:..:..|..    :.|.|:|
Zfish   956 ---------------KRQRKPTKKILESSIEAEPILIPKRKMKSMKICSSGHSTNSGVEQQSSKS 1005

  Fly   722 FKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSC 786
            ..:.|:.   :|..|||    ..|.|.:|| ..|||.|...|..|  |.|.|       |.:..|
Zfish  1006 KNKLSIE---SSDPPSD----PMLKSTEME-IDVSPAVLQTINTE--SADDG-------SDTLRC 1053

  Fly   787 KRARLSPSKRPSGSRKSNRQRSQ-----RRPILSDNPAGHGLTEQDVEETRQSFNTPTPDTRID- 845
            ..::::.|......|:.|.|..:     ||  ||:...|....:::|        .|..:.:.| 
Zfish  1054 SGSQMTESSEFYSEREENSQSDKVLLDSRR--LSEEKGGSTSVKENV--------CPMCEKQGDL 1108

  Fly   846 --SKKRRSGAATTPISSIDSPAMGDSVSTPSSND----------QTDINAALAP----------- 887
              .:.:..||.....:.::.|..|..:....::.          ..|:...:.|           
Zfish  1109 LLCEGQCCGAFHPQCTGLNEPPTGKFLCQECTSGVHSCFACKRLGEDVRRCMVPGCGKFYHGECA 1173

  Fly   888 ---PPAETLSKA------------------PQYIKENGELIRIVR-------------------- 911
               .|...|::|                  |...|  |:|.|.:|                    
Zfish  1174 ASHAPTVPLNRAFRCPLHACLSCFILNPANPSVAK--GQLTRCIRCPVAYHSSDFCIPAGSVTLT 1236

  Fly   912 ---------------MRQEEIINCI-CEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPD-KYV 959
                           .|..|.:|.. |....|.|.::.||.|....|..|..|    |:|: .:.
Zfish  1237 DSNIVCPNHFTPRKGCRNHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNI----DMPEGSWY 1297

  Fly   960 CYICR--------------------------NPQR-GRDSMRFKHDQDWLFEGKLPVAAYHTANP 997
            |..||                          ||:. ..:.:|.|||     .|:.||..:.:.:.
Zfish  1298 CNDCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKDIPENILRMKHD-----VGEFPVLFFGSNDY 1357

  Fly   998 QATKQFELL------KRSHTLTGNLLDA--KRSMHSLLVKINIARNRCHPKLYLWAKK----WDE 1050
            ..|.|..:.      ..|....|..:|:  |:::....::..          .|.|:|    ..|
Zfish  1358 LWTYQARVFPYMEGDANSKEKMGKGVDSTYKKALDEAALRFK----------ELQAEKELRQLQE 1412

  Fly  1051 DNLDSTALTPVKRAKLEAP---------DLPNVPQPEA-AIDPEEC 1086
            |..:.....|.|:.|:..|         ||..:|:... |.|...|
Zfish  1413 DRRNDKKPPPYKQIKVNKPFGKVLIISADLSEIPRCNCKATDENPC 1458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MBD-R2NP_731688.2 THAP 4..86 CDD:283206 19/74 (26%)
TUDOR 292..329 CDD:119391 2/36 (6%)
MeCP2_MBD 449..522 CDD:238690 15/91 (16%)
PHD_SF 919..963 CDD:304600 13/45 (29%)
nsd1bXP_005173940.1 PWWP 132..>204 CDD:321985
TOP2c <652..1020 CDD:330395 94/557 (17%)
PHD_SF 1098..1140 CDD:328929 7/49 (14%)
PHD_SF 1145..1191 CDD:328929 5/45 (11%)
PHD_SF 1193..1245 CDD:328929 6/53 (11%)
PHD4_NSD1 1262..1301 CDD:277126 12/42 (29%)
WHSC1_related 1307..1401 CDD:99899 15/108 (14%)
AWS 1444..1494 CDD:197795 4/15 (27%)
SET 1497..1618 CDD:214614
PHD5_NSD1 1668..1710 CDD:277129
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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