DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and ash1l

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_005159540.1	Gene:	ash1l / 563799	ZFINID:	ZDB-GENE-030131-6101	Length:	2988	Species:	Danio rerio

Alignment Length:	886	Identity:	176/886 - (19%)
Similarity:	273/886 - (30%)	Gaps:	268/886 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 AERKATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVAASSEATVPAPGSASSSNSPLPGT 205
            |||:  :||..||..|         |:..|...|...|    |.:||:     .|.|.....|..
Zfish    22 AERE--KEGVGGKKDD---------EEEKKKREKLRDG----AQNEAS-----GAESGTGDQPQQ 66

  Fly   206 PPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMA 270
            |.::|                           |.||..:     |.|.|||:            .
Zfish    67 PTQFS---------------------------VKETSYS-----EGNVKLKI------------G 87

  Fly   271 IKSERLRQR---LSNRVL-PVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRA 331
            ::::|:::.   |.|.|. |.|    :...|.||.|......|....:|..         .|..:
Zfish    88 LQAKRMKKPPKILENYVCRPAF----RATVRHSGGRGGGRANRGAGASDAN---------SNSTS 139

  Fly   332 VHMNKMPKQLPPV-----QVAEEGASKSPTP--------VGTPVS-SAPV---APK-------RA 372
            ....|..::.|.|     |.|...|:.:|:|        ..|||: :||.   .||       :|
Zfish   140 TSNGKEGEKKPSVNRGASQSAAAPAASTPSPSLPPASINTVTPVNGNAPAKRGPPKLACKSEGKA 204

  Fly   373 STGSLGGS------------SGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDG---EW 422
            ...|:..|            |.|..|.|....||....|.....::..|:....:...||   ..
Zfish   205 DVKSVASSEKPLNLHRPTTESKSHSSGKKNHVPQTNSAPAPSPPAVPPAATSQQDPKIDGILKTP 269

  Fly   423 TCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRL----PPGWIKHMYQRSNVLGKWDVILVSPSGK 483
            .|:::..|.....|   :.....|||..:..:|    ||........|.          |||:..
Zfish   270 QCNFLEGQKEQERG---ISSWGTPTVTEKLAQLIATCPPSKCPKPKARK----------VSPAPA 321

  Fly   484 RFRSKSDLKLFLESQNLVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDVSMNSTLD 548
            ...|...:......:..:.|.:.|..::|.                .||||..||......|...
Zfish   322 HSSSPPLISNLQRPERAMANRNTYSRAVHL----------------AQPPPVSRPPGRPYGSKNK 370

  Fly   549 QSITSQHSLPSTPMPVKESQYMEAPVA-----SLMPPAELMSPQTQPADETKPKIEAEILEASEG 608
            .||..:.|..|..   :||..:...|:     :....:..:|..:.....|....|:..:..::|
Zfish   371 DSILEKFSGTSKK---EESDGLSKGVSGSSSTTTTTTSSALSQNSSRLTTTTSTNESTDINNTDG 432

  Fly   609 GTSQLML------------ADPHVVENGFAFIG--GLKVKIQDNLYVCPREDCAKTYRKEDFLLI 659
            ..||..|            :.|....:....||  ...:.:..:|...|:   |...|.|||
Zfish   433 MKSQSRLGHCPSHSSSAAASPPFSSSSSVERIGSTSCNIGLPGSLTSRPK---ASPSRIEDF--- 491

  Fly   660 HIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQ--VEAVPKNQIPNQQFFAKMHQQDLQQSRS- 721
                         |...|.::.......|..:.:  ..|:...|...::......:.|..:|.|
Zfish   492 -------------SEKDKERDREKDTDSPRDLSKGITPAITGKQDAKERCSLSAPRNDRGKSSSP 543

  Fly   722 FKRQSVSATATSSTPSDITPTKALLSP-------KMEPP------SVSPTVESGIKQEDVSLDAG 773
            .||.....:..|..||....||..:||       :..||      ::||...|....:.:....|
Zfish   544 VKRSPNQESRVSGVPSPAESTKCTISPSYPSGASRSPPPLCDDTGAISPASPSEQDSKPLKKRRG 608

  Fly   774 PTQSFNPSLSRSCKRARLSPSKR-------PSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEET 831
            ....:..::||:.|....|||..       |||...|:..|......|||
Zfish   609 RRPRWTKAVSRTHKSLHESPSNHQQIPTPMPSGLSFSSPIRESVEQPLSD--------------- 658

  Fly   832 RQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAMG-------------------DSVSTPSSND 877
              |:.:|......||..::.|...|.:..:|:||.|                   :....|..:.
Zfish   659 --SYTSPEDSDIFDSSPKKRGRPKTKMPRLDAPAHGCTPNKLAPSKSFSSLLKSKEEQDPPVLHP 721

  Fly   878 QTDIN-----------AALAPP--PAETLSKAPQYIKENGE 905
            :.|.|           ...:||  |.||  :.|....|:||
Zfish   722 EVDFNPPKMMARKRGRPKRSPPTLPQET--QPPTLAPESGE 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	6/36 (17%)
		MeCP2_MBD	449..522	CDD:238690	11/76 (14%)
		PHD_SF	919..963	CDD:304600
ash1l	XP_005159540.1	CytochromB561_N	<529..>674	CDD:286826	36/161 (22%)
		AWS	2037..2088	CDD:197795
		SET	2091..2238	CDD:214614
		COG5076	2281..>2500	CDD:227408
		Bromo_ASH1	2408..2513	CDD:99955
		PHD_ASH1L	2559..2601	CDD:277023
		BAH_polybromo	2633..2772	CDD:240068
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030