DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and KMT2E

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_061152.3	Gene:	KMT2E / 55904	HGNCID:	18541	Length:	1858	Species:	Homo sapiens

Alignment Length:	1187	Identity:	195/1187 - (16%)
Similarity:	345/1187 - (29%)	Gaps:	418/1187 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KNSRISLERQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDTAEIEADQRALQH 103
            :..:::.|.:..:::|   :.|.||:....|..:.|.:.....|.......|| :|.:|...:|.
Human   570 RKRKMTREERKMEAIL---QAFARLEKREKRREQALERISTAKTEVKTECKDT-QIVSDAEVIQE 630

  Fly   104 ASVEGTTETPGNAQSSTNDDVIKATVDQIVAQILSESAERKATEEGKT--GK------------- 153
            .:.|.....|..|:                   ::.:.:||:....:|  |:
Human   631 QAKEENASKPTPAK-------------------VNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSD 676

  Fly   154 ---AADDVKNTPESGEDANKAAAKEPSGTPVAAS--SEATVPAPGSASSSNSPLPGTPPKY--SN 211
               ::.|::.|.:..:..|.....||......|.  :|..|||          |...|.||  :.
Human   677 IQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPA----------LNKCPTKYPKTK 731

  Fly   212 PH--NLTIGARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMAIKSE 274
            .|  |..:..:.|......:.|..|.:.:....:.|..:......|..||....:.:.::...|.
Human   732 KHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSP 796

  Fly   275 RLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVL--FDDGYVKNVRAVHMN-- 335
            .|.:: ..|..|...:...|..||         :::.|..:...:|  |:....:..|:..:|
Human   797 FLSEK-RRRKEPTENISGSCKKRW---------LKQALEEENSAILHRFNSPCQERSRSPAVNGE 851

  Fly   336 -----------KMPKQLPPVQ----------VAEEGASKSPTPVGTPVSS--------------- 364
                       .:|....|::          |..|.::.:|:|..||..:
Human   852 NKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPPRI 916

  Fly   365 ---------------APVAPKRASTGSLGGSSGSSGSKKSKCAPQ--RRDW------------PL 400
                           :||.|  .:.|:.|.:.........:.:|:  ||.:            .|
Human   917 KSDDETCRNGYKPIYSPVTP--VTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDRSSTMLTL 979

  Fly   401 LDMASLDIASLGLPEIPHDGEWT----------C----HWVNDQPIGTEGFLIVGEHQKPTVIVQ 451
            ....:.::..|||.||...|..:          |    ..|:|..:|.:.......|:.......
Human   980 GPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAVEPTALHKTLETPAH 1044

  Fly   452 DWRLPPGWIKHMYQ-RSNVLGKWDVILVSP--SGKRFRSKSDLK--------------------- 492
            |...|...:...:. |..:...|   :.||  :|..|...|:|:
Human  1045 DRAEPNSQLDSTHSGRGTMYSSW---VKSPDRTGVNFSVNSNLRDLTPSHQLEVGGGFRISESKC 1106

  Fly   493 --------LFLESQNLVYNPD--VYDFSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDV------ 541
                    :|:|:.....:.|  |..|      .:.:|..:......||.||:.:.:.:
Human  1107 LMQDDTRGMFMETTVFCTSEDGLVSGF------GRTVNDNLIDGNCTPQNPPQKKKVSLLEYRKR 1165

  Fly   542 -------------------------SMNSTLDQSITSQHS------LPSTPMPVKESQYMEAPVA 575
                                     |:::..|...:|..:      ..|.|:|.
Human  1166 QREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPT----------- 1219

  Fly   576 SLMPPAELMSPQTQPADETKPKIEAEILEASE------GGTS-----------QLMLADPHVVEN 623
                ||.:.:..::......|..:|...|.:|      ..||           .|:|:|..
Human  1220 ----PATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHR---- 1276

  Fly   624 GFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHP 688
                      |.:|:....|...|:.:            |.....:.|.:|.|::|   .|...|
Human  1277 ----------KDKDSGGESPCVSCSPS------------HVQSSPSSHSNHIPQLQ---AKGPVP 1316

  Fly   689 SSIDQVE----------------------------------AVPKNQIPNQ---QFFAKMHQQ-- 714
            |..:.:|                                  ..|.:.||.|   :.|.|...|
Human  1317 SFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWD 1381

  Fly   715 ----------------DLQQSR-SFKRQSVSATATSST-------------PSDITPTKALL--S 747
                            :|||.: |...|::|......|             ||  .|||...  |
Human  1382 STVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPS--VPTKLHCPPS 1444

  Fly   748 PKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRP 812
            |.:|.|..|.|..:.::...:| ...|:|             :|....||..|:.......||.|
Human  1445 PHLENPPKSSTPHTPVQHGYLS-PKPPSQ-------------QLGSPYRPHHSQSPQVGTPQREP 1495

  Fly   813 ILSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAMGDSVSTPSSND 877
            ..:..||...|.....:.|..:..|.||.                         |.|.:|.|..:
Human  1496 QRNFYPAAQNLPANTQQATSGTLFTQTPS-------------------------GQSSATYSQFN 1535

  Fly   878 QTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQH 942
            |..:|:...|||......:..|            ..|:...| ...|.:..|.:.|..:.....:
Human  1536 QQSLNSTAPPPPPPPPPSSSYY------------QNQQPSAN-FQNYNQLKGSLSQQTVFTSGPN 1587

  Fly   943 GACNGIVKEADVPDKYV 959
            .|..|...:..||..:|
Human  1588 QALPGTTSQQTVPGHHV 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	8/46 (17%)
		TUDOR	292..329	CDD:119391	6/38 (16%)
		MeCP2_MBD	449..522	CDD:238690	16/106 (15%)
		PHD_SF	919..963	CDD:304600	9/41 (22%)
KMT2E	NP_061152.3	HCFC1-binding motif (HBM). /evidence=ECO:0000269\|PubMed:23629655	63..66
		PHD_MLL5	120..163	CDD:277025
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..269
		SET	343..452	CDD:214614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..530
		ARGLU	550..>605	CDD:330370	7/37 (19%)
		ERM	<561..>669	CDD:330563	20/121 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..687		8/75 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..960		10/74 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1068		4/31 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1164..1561		82/493 (17%)
		DUF4045	<1310..>1502	CDD:330572	40/210 (19%)
		Med15	1442..>1829	CDD:312941	43/215 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1581..1835		5/24 (21%)
		Atrophin-1	<1741..1846	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930