DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and ASH1L

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001353106.1	Gene:	ASH1L / 55870	HGNCID:	19088	Length:	2969	Species:	Homo sapiens

Alignment Length:	1473	Identity:	264/1473 - (17%)
Similarity:	450/1473 - (30%)	Gaps:	554/1473 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SVEGTTETPGNAQSSTNDDVIKATVDQIVAQILSESAERKATEEGKTGKAADDVKN-------TP 162
            |:.|.|.....|.|..:.::..:.:........:.|..:|.|:......|.|...|       .|
Human  1587 SLGGFTPNSEPASSDEHTNLFTSAIGSCRVSNPNSSGRKKLTDSPGLFSAQDTSLNRLHRKESLP 1651

  Fly   163 ESGEDANKAAAKEP-SGTPVAASSEATVPAP----GSASSSNSPLPGTPPKYSNPHNLTIGARLE 222
            .:.......|..:| |..|....||:|..:|    .|:.|::|.:.|.|.:  :|..:..|..
Human  1652 SNERAVQTLAGSQPTSDKPSQRPSESTNCSPTRKRSSSESTSSTVNGVPSR--SPRLVASGDD-- 1712

  Fly   223 ALSVEGNWLPARIVEVNETEQTLLVRFE---------------RNH----------KLKVSPSTS 262
              ||:.  |..|:|: ||.::.:....:               |:|          .|.|...||
Human  1713 --SVDS--LLQRMVQ-NEDQEPMEKSIDAVIATASAPPSSSPGRSHSKDRTLGKPDSLLVPAVTS 1772

  Fly   263 GSFQEWMAIKSERLR-----QRLSNRVLPVFELDEKCMARWS---GPRKFPGTIRKLL------- 312
            .|....:::.||:|.     ..:...|:...:...:.|..:.   ..:|....:.|:|
Human  1773 DSCNNSISLLSEKLTSSCSPHHIKRSVVEAMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQR 1837

  Fly   313 ----GNDTYEVLFDDGYVKNVRAVHMNKMPKQL--------------PPVQVAEEGASKSPTP-- 357
                ||:         :||. |.....|.|.|.              |.:...||||:...:|
Human  1838 QARTGNN---------FVKR-RPGRPRKCPLQAVVSMQAFQAAQFVNPELNRDEEGAALHLSPDT 1892

  Fly   358 ----VGTPVSSAPVAPK-RASTGSLGGSSGSSGSKKSKCAPQRRDW---PLLDMASLDIASLG-L 413
                :...|.|..:.|: :......|........||.|..|:..:.   ...:.|.::|.|.. .
Human  1893 VTDVIEAVVQSVNLNPEHKKGLKRKGWLLEEQTRKKQKPLPEEEEQENNKSFNEAPVEIPSPSET 1957

  Fly   414 PEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILV 478
            |..|.:.|.|.     ||:    ..::...:||.       .||   |..||::.        |.
Human  1958 PAKPSEPESTL-----QPV----LSLIPREKKPP-------RPP---KKKYQKAG--------LY 1995

  Fly   479 SPSGKRFRSKSDLKLFLESQNLVYNPDVYDFS-----IH----------RRRAKDIN-----AYV 523
            |...|....||.| :.|:.:.|.|.|..:::.     ||          |::..|..     .:.
Human  1996 SDVYKTTDPKSRL-IQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDILWQ 2059

  Fly   524 YTHGYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAPVASLMPP-------- 580
            :.|....:.|..|....:..|..:|               ||.....||...:...|
Human  2060 WKHNQLYKKPDVPLYKKIRSNVYVD---------------VKPLSGYEATTCNCKKPDDDTRKGC 2109

  Fly   581 ----------AELMSPQTQPADE--TKPKIE-------AEILEASEGG----TSQLMLADPHVVE 622
                      || .||.|.|..|  ...:|:       .|...|.|.|    |.:.:.|...::|
Human  2110 VDDCLNRMIFAE-CSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIE 2173

  Fly   623 NGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEF------------------- 668
                ::|                   :...:::|....|..||...
Human  2174 ----YLG-------------------EVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMG 2215

  Fly   669 --AEHVSH-----CPKMQELAVKRTHPSSIDQVEAVPKN------------QIPNQQF----FAK 710
              |..::|     | :||:.:|...:...:..::.:|..            .:..||.    |.|
Human  2216 NEARFINHSCDPNC-EMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEK 2279

  Fly   711 MH------QQDLQQSRSFKRQSVSAT----------------------ATSSTPSD--ITPTKAL 745
            ..      .|.:....|.|.....||                      ..|..||:  .|||:..
Human  2280 CRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINTPTRLT 2344

  Fly   746 LSPKMEPPS------------------------------VSPTVES--------GIKQED--VSL 770
            ...:|:|.|                              .|..:.|        ||.::|  :..
Human  2345 PQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKS 2409

  Fly   771 DAGPTQSFNPSLSRSCKRARLSPSKRP-----------------SG--SRKSNRQRSQRRPILSD 816
            |...||......:||.:..||:.::..                 .|  |.|.:.:::...|:|:.
Human  2410 DVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNL 2474

  Fly   817 NPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSID-----------------SP 864
            .|      ::...:..:..:.|.....|: |:..:|...| :.:.|                 ||
Human  2475 PP------KKKNADYYEKISDPLDLITIE-KQILTGYYKT-VEAFDADMLKVFRNAEKYYGRKSP 2531

  Fly   865 AMGDSVSTPSS--NDQTDINAALAPPPAETLSKAPQ-----YIKENGELIRIVRMRQEEIINCIC 922
            ...|......:  |.:.:.:|.:.....||.|:|..     ..||||      ..:.:::|.|||
Human  2532 VGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENG------HEKDDDVIRCIC 2590

  Fly   923 EYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVC--------------------------- 960
            ...:::||||||:.|:.|||..|.|:  .:|| :.|:|
Human  2591 GLYKDEGLMIQCDKCMVWQHCDCMGV--NSDV-EHYLCEQCDPRPVDREVPMIPRPHYAQPGCVY 2652

  Fly   961 -----------------YICRNPQRGRD------------------------------------- 971
                             |:.|:.:|..|
Human  2653 FICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKNEKEERFA 2717

  Fly   972 ---------------SMRFKHDQDWLFEGKL----PVAA------------YHTANPQATKQFEL 1005
                           |.||.|::  ||...|    |:.|            |....|:..|:.::
Human  2718 FGHHYFRPHETHHSPSRRFYHNE--LFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDV 2780

  Fly  1006 LKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNLDSTALTPVK-------- 1062
            ....:.|       .:|.| |..||:  ||| :|   :..|.:..|:... .|||.|
Human  2781 YICDYRL-------DKSAH-LFYKIH--RNR-YP---VCTKPYAFDHFPK-KLTPKKDFSPHYVP 2830

  Fly  1063 ------------RAKLEAPDLPNVPQPEAAIDPEECQYRLIEHIKVQQSLVLDRLNDIEAEMDEL 1115
                        :::...|.|.::.|.:.|:.       |||.:...|....:.:..:|    |.
Human  2831 DNYKRNGGRSSWKSERSKPPLKDLGQEDDALP-------LIEEVLASQEQAANEIPSLE----EP 2884

  Fly  1116 EKEDTLDDLKDADIST---TKEALATFIKELETMKRLAKLNQV 1155
            |:|....::.:.:..|   ::|..:|...|.....:..:|||:
Human  2885 EREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQI 2927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	8/50 (16%)
		MeCP2_MBD	449..522	CDD:238690	19/92 (21%)
		PHD_SF	919..963	CDD:304600	20/87 (23%)
ASH1L	NP_001353106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..143
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..525
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..583
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	878..966
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1151..1231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1281
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1489..1508
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1580..1711		26/125 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1741..1761		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1911..1991		20/98 (20%)
		Catalytic domain	2069..2288		40/258 (16%)
		AWS	2092..2143	CDD:197795	11/51 (22%)
		SET	2146..2266	CDD:214614	19/143 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2288..2346		11/57 (19%)
		Bromo_ASH1	2443..2548	CDD:99955	16/112 (14%)
		PHD_ASH1L	2586..2628	CDD:277023	20/44 (45%)
		BAH_polybromo	2665..2799	CDD:240068	22/145 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2825..2856		2/30 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2876..2919		8/46 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030