Protein Alignment MBD-R2 and phf3

DIOPT Version :9

• Sequence 1: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: XP_005157087.1
• Gene: phf3 / 553518
• ZFINID: ZDB-GENE-090313-207
• Length: 1691
• Species: Danio rerio
• Alignment Length: 1071
• Identity: 194/1071 - (18%)
• Similarity: 327/1071 - (30%)
• Gaps: 418/1071 - (39%)

  Fly   394 QRRDWPLLDMASLD--IASLGLPEIPHDGEWTCHWVNDQPIGTEGFL----IVGEHQKPTVIVQD 452
            :..|:.|...|..|  :...|:.:.|.|||   |       ...|||    ..|:.|:
Zfish    65 ENEDFKLGSSADADHEMTGAGVRQSPSDGE---H-------NQSGFLQDRRQAGQMQR------- 112

  Fly   453 WRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHRRR-- 515
                    :....|..|.|:    .:.|:.|...|.:......|..:...:||....::..||
Zfish   113 --------RQTASRGRVRGR----RLGPARKAAESYNRESTCSEEHDRDNSPDEKREALLSRRFG 165

  Fly   516 ----AKDINAYVYTH-------GYNPQPPPKPRPMDVSMNSTLDQSITSQ--------------- 554
                ...:|..|...       ||..:..|.|.....|.:::..||:..|
Zfish   166 VHEVDSSMNPVVVLRRLTVTVGGYKIELLPGPSQSFGSFSTSALQSLGFQDDGIIADGLGLDLGQ 230

  Fly   555 --------HSLPST--PMPVKESQYMEAPVASLMPPAELMSP-QTQPADET---KPKIEAEILEA 605
                    :|.|..  .:.:.:|...:.|    |.....::| :.|..:.|   |||:|....|.
Zfish   231 NQDEQVVDNSTPEAVGEVSIDQSTSHDVP----MDFGPYVNPNEVQDTNSTMVLKPKVENATSED 291

  Fly   606 SEGGTSQL----MLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHK 666
            ::...:|:    :.|.....:||.|....:|..:::.
Zfish   292 AKKKNNQIKTQKLSAQKPGNKNGTAARPAVKKLLKNK---------------------------- 328

  Fly   667 EFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMH--QQDLQQSRSFK------ 723
                        |.|:..:..|||..:...:.|.....|.  .|:|  |.::.:.:..|
Zfish   329 ------------QSLSAAKNKPSSPTKPGLLQKESKHPQD--KKIHTGQPEVHKGKPIKVGLKRP 379

  Fly   724 -----------------RQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLD 771
                             ..|.|.||:.|.|...|.||...|   |...:|||  :..|....|:.
Zfish   380 GAALGPKDGSKIQKIQDGHSASKTASPSGPLSPTITKKSSS---ESGPLSPT--NSRKPSSDSVP 439

  Fly   772 AGPTQSFNPSLS----------RSCKRARLSPSK-----------RPSGSRKSNRQRSQRRPILS 815
            ..||.|..||.|          .|.....||||.           .|:.|||.:.......|..|
Zfish   440 LSPTNSRKPSNSVPLSSTNSRKPSSNSVPLSPSNSRKPSSNLVPLSPTNSRKLSSDSGPLSPTNS 504

  Fly   816 DNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDS----------PAMGDSV 870
            ..|:              |.:.|...|   :.:|.|..:...:.|:.|          |..|:..
Zfish   505 RKPS--------------SDSVPLSPT---NSRRPSSESGPGVKSVQSPHPPKKPQNPPTSGNKT 552

  Fly   871 STPSSNDQTDINAALAPPPAETLSKAPQ-----------------YIKENGELIRIV----RMRQ 914
            :.|.:|.|.|......  .|:.:.|..|                 :|.:|..:::..    .:.:
Zfish   553 NPPVANSQGDEEQDKV--KAKKIEKTQQRHKSRNSRSISIEEPQLFIPDNAPVVKKEAEGDALAE 615

  Fly   915 EEII-----NCI-CEYGEEDGLMIQCELCLCWQHGACNGI----VKEADVPD-KYVCYIC----- 963
            .|.:     ||: |:....:..|:.|..|..|.||.|.|:    |::.:..| :|||..|
Zfish   616 SETVWDPTKNCVLCKKPHNNRFMVGCGRCDDWFHGDCVGLDLAKVQQMEKEDQEYVCLKCCAQED 680

  Fly   964 ---------------RNPQRGRDSMR------FKHD-------QDWLFEG--------KLPVAAY 992
                           :..||.:.|:.      |:.|       :|...:|        |:.::..
Zfish   681 EKTQASELSDDKSAAKQKQRPQQSLTAGGIRPFRKDAGERRPSEDSAQKGPNVKHETKKVKISPV 745

  Fly   993 HTANPQA---------TKQFELLKRS--------------------------------------H 1010
            .:..|..         :.:..|||||                                      .
Zfish   746 SSKKPSTGHIRRSVRDSLEEILLKRSKESDLKISSDRPAEVARRTEKELFALFQGVDSKYKNKYR 810

  Fly  1011 TLTGNLLDAKRSM-----------HSLLVKINIARNRCHPKLYLWAKKWDEDNLDS--------- 1055
            :||.||.|||.::           .:.||::. |......:|..|.|:.:...::.
Zfish   811 SLTFNLKDAKNNVLFKRVLKGEVSPADLVRMT-AEELASKELAAWRKRENRHTIEMIEKEQREVE 874

  Fly  1056 ----TALT-----------PVKRAK---------LEAPDLPNVPQPEAAID-PEE---------- 1085
                |.:|           |.|..:         |:..::|....||..:: |::
Zfish   875 RRPITKITHKGEIEIENQEPAKAPEAIEVEPEPVLKVVEVPEEKPPEIKVESPKKSIDTTNLHKS 939

  Fly  1086 ---------CQYRL--------IEHIKVQQSLVLDRLNDIE-----------AEMDELE----KE 1118
                     |..|:        .:.:||..::|..:.:..|           |.||:|.    :|
Zfish   940 HLFDLNCKICTGRMAPPTEEASTKVVKVATTVVRRQSSATEESQPSTTTPTSALMDDLTLRAMEE 1004

  Fly  1119 DTLDDLKD---ADISTTKEALATFIKELETM 1146
            ..|:.|.:   ||...:||..|||:..||::
Zfish  1005 GLLNFLPESSRADSLCSKEDTATFLSSLESL 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690	12/78 (15%)
		PHD_SF	919..963	CDD:304600	16/49 (33%)
phf3	XP_005157087.1	DUF4045	<341..732	CDD:330572	83/416 (20%)
		PHD_PHF3	625..675	CDD:277108	16/49 (33%)
		TFIIS_M	755..863	CDD:311443	18/108 (17%)
		SPOC	1027..1176	CDD:311609	4/9 (44%)
		Endomucin	1271..>1449	CDD:330316
		RRM	1605..>1690	CDD:330708

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030