DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and SETD5

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_011532222.1	Gene:	SETD5 / 55209	HGNCID:	25566	Length:	1500	Species:	Homo sapiens

Alignment Length:	988	Identity:	200/988 - (20%)
Similarity:	322/988 - (32%)	Gaps:	276/988 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NCPSTSRLLEHNGVTYHSFPLDPIIRAIWIKNSR-------ISLERQ--------------ITKS 52
            |||...|  ..|.......|..|.:..|..:..|       :.:|:|              :.:.
Human   449 NCPIQKR--NPNATELPLLPPPPSLPTIGAETRRRKARRKELEMEQQNEASEENNDQQSQEVPEK 511

  Fly    53 VLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMDTAEIEADQRALQHASVEGTTETPGNAQ 117
            |.|.|.| ..:|           .|...|      :.:..|:..||..|.|            ::
Human   512 VTVSSDH-EEVD-----------NPEEKP------EEEKEEVIDDQENLAH------------SR 546

  Fly   118 SSTNDDVIKATVDQIVAQILSESAERKATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVA 182
            .:..|..::|     :........:||...:....::..||:.|..:.|            |||.
Human   547 RTREDRKVEA-----IMHAFENLEKRKKRRDQPLEQSNSDVEITTTTSE------------TPVG 594

  Fly   183 ASSEATVP-APGSASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEVNETEQTLL 246
            ..::...| :..|.|.||..:|.||.        ::|......|..|:....::|......:...
Human   595 EETKTEAPESEVSNSVSNVTIPSTPQ--------SVGVNTRRSSQAGDIAAEKLVPKPPPAKPSR 651

  Fly   247 VRFERNHKLKVSPSTSGSFQEWMAIKSERLRQ-RLSNRVLPVFELDEKCMARWSGPRKFPGTIRK 310
            .|    .|.::|...:.|.|.....|....:| .||...|.....:.......:|.....|..|.
Human   652 PR----PKSRISRYRTSSAQRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENRP 712

  Fly   311 LLGNDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQ---VAE---EGASKSPTPVGTPVSSAPVAP 369
            |.|:|.        .|.::...|:|:...:.|..:   |.|   :.|.|...||..|:.......
Human   713 LTGSDP--------TVVSITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPT 769

  Fly   370 KRAST-GSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPH--------DGEW-TC 424
            ..|:| ..|.|...|               ||:..........|.|.||.        ||.: :|
Human   770 VLATTLNMLPGLIHS---------------PLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSC 819

  Fly   425 --HWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQ-----RSNVLGKWDVILVSPSG 482
              .|:...       |..|..|..:| .|:.|     .:|:||     .|:.:.|.:..|:||.
Human   820 KKRWIKQA-------LEEGMTQTSSV-PQETR-----TQHLYQSNENSSSSSICKDNADLLSPL- 870

  Fly   483 KRFRSKSDLKLFLESQNL--VYNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPKPRPMDVSMNS 545
            |:::|:     :|..||:  :..|                       .:|..||.|       ||
Human   871 KKWKSR-----YLMEQNVTKLLRP-----------------------LSPVTPPPP-------NS 900

  Fly   546 TLDQSITSQHSLPSTPMPVKES-----QYMEAPVASLMPPA---------ELMSPQTQPA---DE 593
               .|.:.|.:.|.:..|.:|.     ..|.:||.||...:         .:.||::.||   :.
Human   901 ---GSKSPQLATPGSSHPGEEECRNGYSLMFSPVTSLTTASRCNTPLQFENISSPESSPAHRPES 962

  Fly   594 TKPKI---------EAEILEAS-----------EGGTSQLMLADPH-----VVENGFAFIGG--- 630
            ..|::         :...|:::           ..|.|.|.   ||     ..|.||....|
Human   963 LSPELCHRKDLDLAKVGYLDSNTNSCADRPSLLNSGHSDLA---PHPSLGPTSETGFPSRSGDGH 1024

  Fly   631 -LKVKIQDN--------------LYVCPREDCAKTYRKE----DFLLIHIRHYH----KEFAEHV 672
             ..|:..|.              |...||.|  ..||..    |...:|:...:    :.|:...
Human  1025 QTLVRNSDQAFRTEFNLMYAYSPLNAMPRAD--GLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRY 1087

  Fly   673 SHCPKMQELAVKRTHPSSIDQVEAVPK-NQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTP 736
            .| ..|::|:.....|......|.||. .|.|.|:     .:..|.:.|..|:::...:|.....
Human  1088 EH-GLMKDLSRGSLSPGGERACEGVPSAPQNPPQR-----KKVSLLEYRKRKQEAKENSAGGGGD 1146

  Fly   737 SDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSR 801
            |..:.:|:..:.:....|||.|...|::.......:.|.:.|:||.|.......:|||  .|...
Human  1147 SAQSKSKSAGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKFSPSHSSMSHLEAVSPS--DSRGT 1209

  Fly   802 KSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTP---TPDTRIDSKKRRSGAATTPISSIDS 863
            .|:..|.|      :|.:...:....||..|:..:.|   ....|:..|...|....:.|:..||
Human  1210 SSSHCRPQ------ENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESNITEKDS 1268

  Fly   864 -PAMGDSVSTPSS 875
             ||.|:...|.||
Human  1269 DPADGEGPETLSS 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	18/97 (19%)
		TUDOR	292..329	CDD:119391	7/36 (19%)
		MeCP2_MBD	449..522	CDD:238690	16/79 (20%)
		PHD_SF	919..963	CDD:304600
SETD5	XP_011532222.1	SET_SETD5	305..454	CDD:380958	3/4 (75%)
		COG5644	<473..>693	CDD:227931	49/278 (18%)
		PLN02217	<1360..1467	CDD:215130
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930