DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and NSD3

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_075447.1	Gene:	NSD3 / 54904	HGNCID:	12767	Length:	1437	Species:	Homo sapiens

Alignment Length:	867	Identity:	154/867 - (17%)
Similarity:	259/867 - (29%)	Gaps:	388/867 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 PQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKES----------------QYMEAPVASLM 578
            |||||.|                   |:|.|.:|.|..                :..|:.:.
Human   131 PQPPPPP-------------------SVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLC--- 173

  Fly   579 PPAELMSPQTQPADETK-----------------------------PKIEAE--------ILEAS 606
              .:|:: :.|.::.||                             ||:|.|        :...|
Human   174 --GDLLN-EVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVS 235

  Fly   607 EGGTSQLMLADPHVVENGFAFI------GGLKVKIQDNLY----VCPREDC-------------- 647
            |....:.:|.:...|:...:.:      .|:|.::.|.::    ..|...|
Human   236 EKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI 300

  Fly   648 ----AKTYRKEDF------LLIH---IRHY--HKEFAEHVSHCPKM------------------- 678
                |:.|..:.|      ..:|   :|.|  ||::.|.::...|.
Human   301 NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRER 365

  Fly   679 ---------QELAVKRTHPSSIDQV----------EA-------------VPKNQIPNQQFFAKM 711
                     .|.|:|.|....|:|.          ||             |.|.:.|......:.
Human   366 AQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQP 430

  Fly   712 HQQDLQQ------SRSFKRQS-------------------VSATATSSTPSDITPTKALLSPKME 751
            .|.:..:      |...:|.|                   .:|.|..|.|:.||..|..|.  ::
Human   431 EQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLD--LQ 493

  Fly   752 PPSVSPTV--------------------------------ESGIKQEDVSLDAGPTQSFNPSLSR 784
            ..::||.|                                |..::.:|..:.:.|.|. |...::
Human   494 KCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQR-NEKPTQ 557

  Fly   785 SCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNPAGHG--------LTEQDVEETRQSFNTPTPD 841
            |     :|..:..|||..|..::.|||.|.:.:.:...        :.::.||...|:    |..
Human   558 S-----VSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQA----TVK 613

  Fly   842 TRI--------DS---KKRRSGAAT---------TPISSIDSPAMGD-------SVSTPSSNDQT 879
            |.:        ||   .|:||.|:|         ...|..||..:.|       .|.:||:....
Human   614 TGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADA 678

  Fly   880 DINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCE-LCLCWQHG 943
            |::...:..  .:||:            |...|.:::.:..|||...:.  :|.|| .|....|.
Human   679 DVSDVQSMD--SSLSR------------RGTGMSKKDTVCQICESSGDS--LIPCEGECCKHFHL 727

  Fly   944 ACNGIVKEADVPD-KYVCYICRNPQR--------GRDSMR--------FKHD------QDWLFEG 985
            .|.|:   |.:|| |::|..|:..|.        |:|..|        |.|:      ...:||.
Human   728 ECLGL---ASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFES 789

  Fly   986 K-------------------------------LPVAAYHT------ANPQATKQFELLKRSHTLT 1013
            |                               .|| |||:      |.......:.|:..:|
Human   790 KGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPV-AYHSGDACIAAGSMLVSSYILICSNH--- 850

  Fly  1014 GNLLDAKRSMHSLLVKIN---------IARNRCHPKLYLWAKK----WDEDNLDSTALTPVKRAK 1065
                 :|||.:|..|.:.         |.::...|....:|.|    .:|.|            :
Human   851 -----SKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESN------------R 898

  Fly  1066 LEAPDLPNVPQPEAAIDPEECQ 1087
            .|...||.:|...|:  .::|:
Human   899 AELMKLPMIPSSSAS--KKKCE 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600	15/45 (33%)
NSD3	NP_075447.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..157		11/44 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..252		11/70 (16%)
		PWWP domain; Pfam PF00855	264..324		8/59 (14%)
		MSH6_like	267..383	CDD:99898	17/115 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..365		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..465		7/58 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..696		37/179 (21%)
		TNG2	<602..746	CDD:227367	39/166 (23%)
		PHD type zinc finger motif	697..738		13/45 (29%)
		PHD1_NSD3	703..746	CDD:277119	15/47 (32%)
		PHD type zinc finger motif	745..795		10/49 (20%)
		PHD2_NSD3	751..797	CDD:277122	8/45 (18%)
		PHD3_NSD3	798..850	CDD:277125	7/52 (13%)
		PHD type zinc finger motif	858..945		13/75 (17%)
		PHD4_NSD3	917..952	CDD:277128	1/2 (50%)
		PWWP domain; Pfam PF00855	954..1013
		WHSC1_related	958..1051	CDD:99899
		AWS	1094..1144	CDD:197795
		SET	1145..1268	CDD:214614
		SET domain	1149..1255
		PHD type zinc finger motif	1317..1364
		PHD5_NSD3	1323..1365	CDD:277131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030