DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and MBD3

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001268382.1	Gene:	MBD3 / 53615	HGNCID:	6918	Length:	291	Species:	Homo sapiens

Alignment Length:	270	Identity:	56/270 - (20%)
Similarity:	105/270 - (38%)	Gaps:	67/270 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 LPPGWIKHMYQRSNVL--GKWDVILVSPSGKRFRSKSDLKLFL-ESQNLVYNPDVYDFSIHRRRA 516
            ||.||.:....|.:.|  |..||...|||||:||||..|..:| .|.:|    ..:||...:...
Human    11 LPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDL----STFDFRTGKMLM 71

  Fly   517 KDINAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKE-SQYMEAPVASLM-- 578
            ..:|.......|:.....|.:| |:                 :|.:||:: :...:.||..:.
Human    72 SKMNKSRQRVRYDSSNQVKGKP-DL-----------------NTALPVRQTASIFKQPVTKITNH 118

  Fly   579 PPAELMSPQTQPADETKP-------------KIEAEILEASE----------GGTSQLMLA--DP 618
            |..::.|...:..|:.:.             .|..|:::..:          |.|.:.:|:  ..
Human   119 PSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSAIAS 183

  Fly   619 HVVENGFAFIGGLKVKIQDN--LYVCPREDCAKTY-------RKEDFLLIHIRHYHKE--FAEHV 672
            .:..:.....|.|...::.|  :::...:...|.:       ||::.|:..:|...:|  .|:.:
Human   184 ALHTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEEALMADML 248

  Fly   673 SHCPKMQELA 682
            :|   ::|||
Human   249 AH---VEELA 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690	25/69 (36%)
		PHD_SF	919..963	CDD:304600
MBD3	NP_001268382.1	MeCP2_MBD	5..79	CDD:238690	25/71 (35%)
		MBDa	82..148	CDD:406868	12/83 (14%)
		MBD_C	153..243	CDD:404858	13/89 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..291		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900