Protein Alignment MBD-R2 and PHF20

DIOPT Version :10

• Sequence 1: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_057520.2
• Gene: PHF20 / 51230
• HGNCID: 16098
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 1199
• Identity: 251/1199 - (20%)
• Similarity: 409/1199 - (34%)
• Gaps: 465/1199 - (38%)

  Fly   217 IGARLEALSVEGNWLPARIVEVNETEQTLLVRFER-NHKLKVSPSTSGSFQEWMAIKSERLR--Q 278
            :||:|||.....||.||.|.:::..|..:|:.|:| ||:          :.||....|..||  :
Human    15 VGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHR----------YDEWFCWDSPYLRPLE 69

  Fly   279 RLSNRVLPV--------FELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMN 335
            ::..|...:        |:::|:.:|.||..|.:|..:..:..:.||.|.|.||.|:.|:.:|:
Human    70 KIQLRKEGLHEEDGSSEFQINEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHV- 133

  Fly   336 KMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRDWPL 400
                         :..||....||.      ..||.....||    .||..|:.|...||:
Human   134 -------------KAFSKDQNIVGN------ARPKETDHKSL----SSSPDKREKFKEQRK---- 171

  Fly   401 LDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGT---------EGFLIVGEHQKPTVIVQDWRLP 456
               |::::..        |.|       |:|:.|         ||.||..|..|    |.:..||
Human   172 ---ATVNVKK--------DKE-------DKPLKTEKRPKQPDKEGKLICSEKGK----VSEKSLP 214

  Fly   457 PGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQN-LVYNPDVYDFSIHRRRAKDIN 520
            ..            .|.|...:|.:.:.:  ..|.::..:.:| :|.:|........|:|.:
Human   215 KN------------EKEDKENISENDREY--SGDAQVDKKPENDIVKSPQENLREPKRKRGR--- 262

  Fly   521 AYVYTHGYNPQPPPKPRPMDVSMNSTLDQSIT----------------SQHSLPSTPMPVKESQY 569
                        ||...|..|..||...|.||                .:..|.......|...|
Human   263 ------------PPSIAPTAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNY 315

  Fly   570 ME----------APVASLMPPAELMSP--------QTQPADE----TKPKIEAEI---LEASE-- 607
            .|          :...|.....|::.|        .|.|..:    ||...|.::   |||.:
Human   316 SENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDTLSSTKESEEGQLKSALEAGQVS 380

  Fly   608 -----------GGTSQLMLADPHVVENGFAFIGGLK-------VKIQ------------------ 636
                       .|.:.|.|..|.:.||      .:|       |::|
Human   381 SALTCHSFGDGSGAAGLELNCPSMGEN------TMKTEPTSPLVELQEISTVEVTNTFKKTDDFG 439

  Fly   637 ---------DNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSID 692
                     |:.:.|...||.|.:||...|..|::::|           .|::         |::
Human   440 SSNAPAVDLDHKFRCKVVDCLKFFRKAKLLHYHMKYFH-----------GMEK---------SLE 484

  Fly   693 QVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSP 757
            ..|:..|..:               |:|        ..:.|..||..|.|:..:|      :.||
Human   485 PEESPGKRHV---------------QTR--------GPSASDKPSQETLTRKRVS------ASSP 520

  Fly   758 TVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNPAGHG 822
            |.:...|.::        :.|.       :..|:.|.|:    :|..::.....|
Human   521 TTKDKEKNKE--------KKFK-------EFVRVKPKKK----KKKKKKTKPECP---------- 556

  Fly   823 LTEQDVEETRQSFNTPTPD-----TRIDSKKRRSGAATTPISSIDSPAMG-----------DSVS 871
             ..:::.:|.|.   |:|.     ||..| ..:.|...:|  .:..|..|           |::|
Human   557 -CSEEISDTSQE---PSPPKAFAVTRCGS-SHKPGVHMSP--QLHGPESGHHKGKVKALEEDNLS 614

  Fly   872 TPS------SNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGL 930
            ..|      |:|:...:..:...|.|.|....:|              ..|::.||||..||:..
Human   615 ESSSESFLWSDDEYGQDVDVTTNPDEELDGDDRY--------------DFEVVRCICEVQEENDF 665

  Fly   931 MIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLPVAAYHTA 995
            |||||.|.|||||.|.|:::| :||:||.||:|::|...|...::.:|::||..|.:...|:...
Human   666 MIQCEECQCWQHGVCMGLLEE-NVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEE 729

  Fly   996 NPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNLDSTA--- 1057
            | .:.:..:.:..:|.|.|::......:|.|.:|::|.::|.||.|.||.:.|.:.:.:..:
Human   730 N-YSHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFR 793

  Fly  1058 LTPV--KRAKLEAPDLPNV------PQPEA----------------------------------- 1079
            ..||  .|:|.|||....:      |:|.|
Human   794 NIPVTDTRSKEEAPSYRTLNGAVEKPRPLALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVE 858

  Fly  1080 ----AID-------------------------------------------------PEEC----- 1086
                |:|                                                 |||.
Human   859 TRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSKKALPEEAPARKL 923

  Fly  1087 ---------------QYRLIEHIKVQQSLVLDRLNDIEAEMDELEKEDTLDDLKDADISTTKEAL 1136
                           |:.|:.|::..|..|..|::.||.|:|.|  |..||
Human   924 LDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVL--ESWLD-------------- 972

  Fly  1137 ATFIKELETMKRLAKLNQVAN-MKQTLRD 1164
              :..|||..:.||:|.|:.: :||.|.|
Human   973 --YTGELEPPEPLARLPQLKHCIKQLLMD 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	5..84	CDD:461662
		MBT_PHF20L1-like	215..282	CDD:439094	21/67 (31%)
		Tudor_PHF20-like	288..337	CDD:410457	16/48 (33%)
		MeCP2_MBD	449..522	CDD:238690	12/73 (16%)
		PHD_SF	919..963	CDD:473978	26/43 (60%)
		PRK04778	<1099..>1153	CDD:179877	15/53 (28%)
PHF20	NP_057520.2	MBT_PHF20L1-like	13..69	CDD:439094	21/63 (33%)
		Tudor_PHF20	87..139	CDD:410524	17/65 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..336		50/258 (19%)
		DUF3776	176..280	CDD:463645	29/151 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..611		32/203 (16%)
		PHD_PHF20	654..697	CDD:277104	26/43 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..912		0/45 (0%)