DRSC/TRiP Functional Genomics Resources

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Protein Alignment MBD-R2 and PHF20L1

DIOPT Version :9

Sequence 1:NP_731688.2 Gene:MBD-R2 / 41498 FlyBaseID:FBgn0038016 Length:1169 Species:Drosophila melanogaster
Sequence 2:XP_011515377.1 Gene:PHF20L1 / 51105 HGNCID:24280 Length:1023 Species:Homo sapiens


Alignment Length:1186 Identity:254/1186 - (21%)
Similarity:423/1186 - (35%) Gaps:407/1186 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 PPKYSNPHNLT--IGARLEALSVEGNWLPARIVEVNETEQTLLVRFER-NHKLKVSPSTSGSFQE 267
            ||   |...:|  ||||||||.....|.|:||.:::..|..:||.||| :|:          :.|
Human     5 PP---NRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSHR----------YDE 56

  Fly   268 WMAIKSERLR--QRLSNRVLPV--------FELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFD 322
            |:...|.|||  :|.:.|...:        |:..|:.:|||:..|.:|..|..:....|:.|.|.
Human    57 WIYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFY 121

  Fly   323 DGYVKNVRAVHMNKMPKQLPPVQVAEEGASKSP-------TPVGT------------PVSSAPVA 368
            ||.::.::.:|:..||:.... |...:..|:.|       .|.|:            .|.:|..|
Human   122 DGVIRCLKRMHIKAMPEDAKG-QFLFQVKSQHPLSWCCPIDPAGSCNQSMGSEDWIALVKAAAAA 185

  Fly   369 PKRASTGSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIAS-LGLPEIPHDGEWTCHWVNDQPI 432
            ..:..|||...:|.:|...|.|   ..|.|..:.....:.:: :..|::...        .|.|.
Human   186 AAKNKTGSKPRTSANSNKDKDK---DERKWFKVPSKKEETSTCIATPDVEKK--------EDLPT 239

  Fly   433 GTEGFLIVGEHQK--PTVIVQDWRLPPGWIKHMYQRSNVLG------------------------ 471
            .:|.|  ||.|.:  |.::...   |...:.:  :|.|..|                        
Human   240 SSETF--VGLHVENVPKMVFPQ---PESTLSN--KRKNNQGNSFQAKRARLNKITGLLASKAVGV 297

  Fly   472 -----KWD----------VILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHRRRAK---- 517
                 |.|          .|...|..:: ::::|:.....:|    .|.:...::...:|:    
Human   298 DGAEKKEDYNETAPMLEQAISPKPQSQK-KNEADISSSANTQ----KPALLSSTLSSGKARSKKC 357

  Fly   518 -----DINAYVYTHGYNPQPPPKP------RPMDVSMNSTLDQSITSQHSLP---STPMPVKESQ 568
                 |.:..:       :||..|      :..|:::.|.|..|:.::.|.|   :.|.|.|.|:
Human   358 KHESGDSSGCI-------KPPKSPLSPELIQVEDLTLVSQLSSSVINKTSPPQPVNPPRPFKHSE 415

  Fly   569 YMEAP--VASLMPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLMLAD-PHVVENGFAFIG- 629
            .....  :|:|..|.:.:...:.|:    |..:.::...|.....:..:.: |.|.......:| 
Human   416 RRRRSQRLATLPMPDDSVEKVSSPS----PATDGKVFSISSQNQQESSVPEVPDVAHLPLEKLGP 476

  Fly   630 --------GLKVK---IQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAV 683
                    |.:|.   ..|:.|   |.:|.:..:::..:|.:               |..:.:|.
Human   477 CLPLDLSRGSEVTAPVASDSSY---RNECPRAEKEDTQMLPN---------------PSSKAIAD 523

  Fly   684 KRTHPSS--IDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALL 746
            .|..|::  |.:.|...|.:..:...|.|..::|  :.|..||.                 |...
Human   524 GRGAPAAAGISKTEKKVKLEDKSSTAFGKRKEKD--KERREKRD-----------------KDHY 569

  Fly   747 SPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQR---- 807
            .||.:.....   :...||.|.|       .:..|.....:|.. ||..|.|||..::|..    
Human   570 RPKQKKKKKK---KKKSKQHDYS-------DYEDSSLEFLERCS-SPLTRSSGSSLASRSMFTEK 623

  Fly   808 ----SQRRPILSDNPAGHGLTEQDV-------------EETRQSFNTPTPDTRIDSKKRRSGAAT 855
                ...|.|||.:.:|..|::.|.             :|..|.|                    
Human   624 TTTYQYPRAILSVDLSGENLSDVDFLDDSSTESLLLSGDEYNQDF-------------------- 668

  Fly   856 TPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINC 920
                        ||.:...|.|:.|   ||                             .||:.|
Human   669 ------------DSTNFEESQDEDD---AL-----------------------------NEIVRC 689

  Fly   921 ICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEG 985
            |||..||:|.|||||.||||||..|.|:::|: :|::|:|||||:|...|.|.::::|::||..|
Human   690 ICEMDEENGFMIQCEECLCWQHSVCMGLLEES-IPEQYICYICRDPPGQRWSAKYRYDKEWLNNG 753

  Fly   986 KLPVAAYHTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWA---KK 1047
            ::...::...|.......:::. :|.|..::......:|.|.:||.|.:|:.||.|:|||   |:
Human   754 RMCGLSFFKENYSHLNAKKIVS-THHLLADVYGVTEVLHGLQLKIGILKNKHHPDLHLWACSGKR 817

  Fly  1048 WDEDNL-----DSTALTPVKRAK-------LEAPDLP-------------------------NVP 1075
            .|:|.:     ...|...|.|.:       .|.|.||                         ::.
Human   818 KDQDQIIAGVEKKIAQDTVNREEKKYVQNHKEPPRLPLKMEGTYITSEHSYQKPQSFGQDCKSLA 882

  Fly  1076 QPEAAID-----------------------------PE--------------------------- 1084
            .|.::.|                             ||                           
Human   883 DPGSSDDDDVSSLEEEQEFHMRSKNSLQYSAKEHGMPEKKNPAEGNTVFVYNDKKGTEDPGDSHL 947

  Fly  1085 ECQYRLIEHIKVQQSLVLDRLNDIEAEMDELEKEDTLDDLKDADISTTKEALATFIKELETMKRL 1149
            :.|..|:.||:..|:.|..|::.||.|:|.|  |..||                |..|||....|
Human   948 QWQLNLLTHIENVQNEVTSRMDLIEKEVDVL--ESWLD----------------FTGELEPPDPL 994

  Fly  1150 AKLNQV-ANMKQTLRD 1164
            |:|.|: .::||.|.|
Human   995 ARLPQLKRHIKQLLID 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MBD-R2NP_731688.2 THAP 4..86 CDD:283206
TUDOR 292..329 CDD:119391 12/36 (33%)
MeCP2_MBD 449..522 CDD:238690 13/120 (11%)
PHD_SF 919..963 CDD:304600 25/43 (58%)
PHF20L1XP_011515377.1 MBT 3..68 CDD:302657 29/75 (39%)
TUDOR 90..135 CDD:119391 13/44 (30%)
DUF3776 214..322 CDD:289391 16/122 (13%)
PHD20L1_u1 323..388 CDD:293265 9/76 (12%)
PHD_PHF20L1 688..733 CDD:277103 27/45 (60%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141600
Domainoid 1 1.000 174 1.000 Domainoid score I3689
eggNOG 1 0.900 - - E1_KOG1844
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 232 1.000 Inparanoid score I3436
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147824at2759
OrthoFinder 1 1.000 - - FOG0001785
OrthoInspector 1 1.000 - - otm40756
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15856
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X2262
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1111.020

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