DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and MECP2

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001104262.1	Gene:	MECP2 / 4204	HGNCID:	6990	Length:	498	Species:	Homo sapiens

Alignment Length:	673	Identity:	137/673 - (20%)
Similarity:	218/673 - (32%)	Gaps:	257/673 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 SPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFD 322
            :||..|...|     .|||.::..::.|.  .|.:|       |.||     |.:..|..|
Human     8 APSGGGGGGE-----EERLEEKSEDQDLQ--GLKDK-------PLKF-----KKVKKDKKE---- 49

  Fly   323 DGYVKNVRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSK 387
                 .....|....|......:.||.|  |:.|..|:  .|||..|:            :|.|.
Human    50 -----EKEGKHEPVQPSAHHSAEPAEAG--KAETSEGS--GSAPAVPE------------ASASP 93

  Fly   388 KSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQD 452
            |.:.:..|...|:.|                                          .||
Human    94 KQRRSIIRDRGPMYD------------------------------------------DPT----- 111

  Fly   453 WRLPPGWIKHMYQRSN--VLGKWDVILVSPSGKRFRSKSDLKLFLES-QNLVYNPDVYDFSI--- 511
              ||.||.:.:.||.:  ..||:||.|::|.||.||||.:|..:.|. .:...:|:.:||::
Human   112 --LPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGR 174

  Fly   512 ---HRRRAKDINAYVYTHGYNPQPPPKP-------------RPMDVSMNSTLDQSITSQHSLPST 560
               .||..|              ||.||             ||.  ...:|..::.||:
Human   175 GSPSRREQK--------------PPKKPKSPKAPGTGRGRGRPK--GSGTTRPKAATSE------ 217

  Fly   561 PMPVKESQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEASEGG-----TSQLMLADPHV 620
              .|:..:.:|.....|:..   |..||.|..:            :|||     |..:::..|
Human   218 --GVQVKRVLEKSPGKLLVK---MPFQTSPGGK------------AEGGGATTSTQVMVIKRP-- 263

  Fly   621 VENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAV-- 683
                     |.|.|.:.:....|:    |..||...::.......|:.|...|....:||..:
Human   264 ---------GRKRKAEADPQAIPK----KRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPI 315

  Fly   684 --KRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTK--- 743
              ::|..:...:|:.|.|..:.:.  ..:...:.|:..:|..|:|..::....:.|..:|.|
Human   316 KKRKTRETVSIEVKEVVKPLLVST--LGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEH 378

  Fly   744 --------------ALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNP-SLSRS-CKRARL- 791
                          .||.|...||   |..||   .||      ||....| .||.| ||..::
Human   379 HHHHHHSESPKAPVPLLPPLPPPP---PEPES---SED------PTSPPEPQDLSSSVCKEEKMP 431

  Fly   792 ------------SPSK-RP-------SGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFN 836
                        .|:| :|       :..:..:|...:|:.|:|                 .|..
Human   432 RGGSLESDGCPKEPAKTQPAVATAATAAEKYKHRGEGERKDIVS-----------------SSMP 479

  Fly   837 TPTPDTRIDSKKRRSGAATTPIS 859
            .|..:..:||:        ||::
Human   480 RPNREEPVDSR--------TPVT 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	7/36 (19%)
		MeCP2_MBD	449..522	CDD:238690	26/81 (32%)
		PHD_SF	919..963	CDD:304600
MECP2	NP_001104262.1	MBD	104..181	CDD:128673	28/125 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12235
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900