DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and MBD-like

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001262421.1	Gene:	MBD-like / 41151	FlyBaseID:	FBgn0027950	Length:	340	Species:	Drosophila melanogaster

Alignment Length:	256	Identity:	61/256 - (23%)
Similarity:	89/256 - (34%)	Gaps:	70/256 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 TGKAADDVKN---TPESGEDANKAAAKEPSGTPVAASSEATVPAPGSASSSNSPLPGTPPKYSNP 212
            :|.||:.:|.   ..:.|..|..|.|..|:.|   |||.||..|   ||:|    |.|..:....
  Fly   120 SGSAANALKRKFARSQGGNAAGAAGAAPPAAT---ASSAATATA---ASAS----PSTANRQQQQ 174

  Fly   213 HNLTIGARLEALSVEGNWLPARIVEVNETEQTLL--VRFERNHKLKVSPSTSGSFQEWMAIKSER 275
            ..|:     .||..:.:.:|    .:.:|.....  |...||||           |:....|:|
  Fly   175 IELS-----RALRTDVSLVP----PIRQTASIFKQPVTVIRNHK-----------QDPAKAKNE- 218

  Fly   276 LRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQ 340
              .:...|..|.....||.:.|          :|..  :|:.|.|.|....|.:|.|..|
  Fly   219 --PKHGTREKPKQLFWEKRLER----------LRAC--HDSGEELDDISLPKTIRTVGPN----- 264

  Fly   341 LPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRDWPLL 401
                 |.|:          |.:.|...|....:.|..|.||..:...|:..|....:.||:
  Fly   265 -----VNEQ----------TVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLM 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	9/36 (25%)
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600
MBD-like	NP_001262421.1	MBD	13..98	CDD:279737
		MBDa	172..241	CDD:293172	18/101 (18%)
		MBD_C	246..338	CDD:290755	20/85 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4161
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900