DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and Mbd3

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_038935328.1	Gene:	Mbd3 / 362834	RGDID:	1307389	Length:	326	Species:	Rattus norvegicus

Alignment Length:	292	Identity:	60/292 - (20%)
Similarity:	108/292 - (36%)	Gaps:	71/292 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 LPPGWIKHMYQRSNVL--GKWDVI------------LVSPSGKRFRSKSDLKLFL-ESQNLVYNP 504
            ||.||.:....|.:.|  |..||.            |.|||||:||||..|..:| .|.:|
  Rat    11 LPQGWEREEVPRRSGLSAGHRDVFYYRAGDRTQGLALPSPSGKKFRSKPQLARYLGGSMDL---- 71

  Fly   505 DVYDFSIHRRRAKDINAYVYTHGYNPQPPPK------PRPMDVSMN--STLDQSITSQHSLP--S 559
            ..:||...:.....:|.......|:.....|      |.|.:.|..  ......:.|....|  :
  Rat    72 STFDFRTGKMLMNKMNKSRQRVRYDSSNQVKALAKHLPGPSNPSWTPVGAARCRVFSPQGKPDLN 136

  Fly   560 TPMPVKE-SQYMEAPVASLM--PPAELMSPQTQPADETKP-------------KIEAEILEASE- 607
            |.:||:: :...:.||..:.  |..::.|...:..|:.:.             .|..|::...:
  Rat   137 TALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLSAFDIAEELVRTMDL 201

  Fly   608 ---------GGTSQLMLA--DPHVVENGFAFIGGLKVKIQDN--LYVCPREDCAKTY-------R 652
                     |.|.:.:|:  ...:..:.....|.|...::.|  :::...:...|.:       |
  Rat   202 PKGLQGVGPGCTDETLLSAIASALHTSTLPITGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDDIR 266

  Fly   653 KEDFLLIHIRHYHKE--FAEHVSHCPKMQELA 682
            |::.|:..:|...:|  .|:.::|   ::|||
  Rat   267 KQEELVQQVRKRLEEALMADMLAH---VEELA 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690	26/81 (32%)
		PHD_SF	919..963	CDD:304600
Mbd3	XP_038935328.1	MeCP2_MBD	5..91	CDD:238690	26/83 (31%)
		MBDa	131..188	CDD:406868	9/56 (16%)
		MBD_C	193..283	CDD:404858	13/89 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900