Protein Alignment MBD-R2 and set-24

DIOPT Version :10

• Sequence 1: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_496579.3
• Gene: set-24 / 3565594
• WormBaseID: WBGene00012845
• Length: 868
• Species: Caenorhabditis elegans
• Alignment Length: 1082
• Identity: 190/1082 - (17%)
• Similarity: 347/1082 - (32%)
• Gaps: 388/1082 - (35%)

  Fly    11 PSTSRLLEHNGVTYHSFPLDPIIRAIWIKNSRISLERQITKSVLVCSRHFRRLDFNTIRNGKYLL 75
            |:.|.||....|...:.  |.:.|.:.::|::.:| |...:.|||.::        ||...|.::
 Worm    18 PAVSSLLAKQPVMLGAD--DLLNRTVIVQNAQRAL-RNEHEHVLVANK--------TILVNKPII 71

  Fly    76 KPRVF---PTVFPWGKMDTAEIEADQRALQHASVEG-----TTETPGN-----AQSSTNDDVIKA 127
            :.:.|   |...|      ..:.:..|...:..:.|     ||...||     .:|..|:..::.
 Worm    72 EMKGFMSLPPEIP------CSVGSTPRTFMYYGIGGKPICITTSELGNYSEITRRSCQNNSTLRH 130

  Fly   128 TV------------DQIVAQ------------ILSESAERKATE---------EGKTGKAADDVK 159
            .:            .:::.|            ||||:....||.         |.:...||....
 Worm   131 ILGSKSNFRVMIVSTKVILQDHEITLPFDKNWILSETPLHCATHFDKMIECPMESRRVLAALGRA 195

  Fly   160 NTPESGEDANKAAAKEPSGTPVAASSEATVPAPGSASSSNSPLPGTPPKYSNPHNLTIGARLEAL 224
            ...|..|..:|..|...|.||.:.:.                 |..||:
 Worm   196 RIAEEKEFWSKNRAIARSFTPRSMAK-----------------PPPPPQ---------------- 227

  Fly   225 SVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSG--SFQEWMAIKSERLRQRLSNRVLPV 287
                        ::..|||            |.:..||.  .|.:::|.||.      |:.:.|:
 Worm   228 ------------KITTTEQ------------KTAEITSADVDFLQFLAQKSS------SDEIRPL 262

  Fly   288 --FELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKN--VRAVHMNKMPKQLPPVQVAE 348
              |::.|:.:                   ||||....:.|:.|  :|.:.|     ::|.::..:
 Worm   263 FRFQICEEYI-------------------DTYENPSSENYLNNRFLRVLAM-----RIPLLRGFD 303

  Fly   349 -EGASKSPTPVGTPV-----------SSAPVAPK------RASTG--SLGGSSGSSG-------- 385
             |..::.....|.|:           .|..:..|      :|:.|  :|.||....|
 Worm   304 LETKARMMFVAGIPLEERFLIELRRYGSVELDEKHRITNFKANNGDFTLKGSHDDDGKQAEYQKF 368

  Fly   386 --SKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHW------VNDQP-IGTEGFLIVG 441
              |||.|.:|:      ...:|...|.|......:..:.:.:|      :..:| |..:.||.:|
 Worm   369 LNSKKEKPSPR------APSSSPPAALLNHSYCENPPKTSENWPQELKLIEQKPQIEDQEFLFLG 427

  Fly   442 EHQKPTVIVQDWRLPPGWIKHMYQ--RSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNP 504
            :....|   |....|...|:.:|:  ::|:.|.                       |........
 Worm   428 DEISET---QQQEPPQDDIQFLYEGNQANITGN-----------------------EQPEACAQA 466

  Fly   505 DVYDFSIHRRRAKDINAYVYTHGYNPQPPPK---PRPMDVSMNSTLDQSITSQHSLPSTPMPVKE 566
            .:|                    |.|:|...   |.|..::..|:.:.::::
 Worm   467 QLY--------------------YGPEPGVSVQIPAPAQLTTESSNETALST------------- 498

  Fly   567 SQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLMLADPHVVENG-FAFIGG 630
                   ::.|.|                    :.|.|.|...:|:|...:..:.||. |||:..
 Worm   499 -------ISDLFP--------------------SVIAETSPWTSSRLSRVNYELFENELFAFLAE 536

  Fly   631 LKVKIQDNLYVCPREDCAKTYRKEDFLLIHI----RHYHKEFAEHVSHCP------KMQELA--- 682
            ........:.:.|   ..:.:|.|...|:.:    |.:.:..|..:|..|      |::.|.
 Worm   537 KSKMATGPVILTP---VLEEFRVEGRYLMTLETIRRRFRQRLARKISSLPDYDTDTKIRMLVFTS 598

  Fly   683 -------VKRTHPSSIDQVEAVPKNQIPNQQFF-------AKMHQQDLQQSRSFKRQSVSATATS 733
                   :|....|::  ||....|:|...|.|       :..:.:..:..|:|.|:|...|...
 Worm   599 SAITDSFLKILQQSAV--VEVDDSNRITKYQAFDENGLKISTRYTKIPEFKRAFLRRSDYGTGKV 661

  Fly   734 STP------SDITPTKALLSPKMEPPSVSPTVE----SGIKQE-----DVSLDAGPTQSFNPSLS 783
            ..|      .|...:.:..|..:.||.|...||    |.:..|     |:|..:..|.:.:
 Worm   662 DGPMKRPCLEDFNASSSSSSSVLAPPRVDEHVEWELMSSMHHEADEICDISRMSAETSTIS---- 722

  Fly   784 RSCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKK 848
             :|.....|..::.:.|.|...:..:...:..::|...||.||    .||         ||:  .
 Worm   723 -TCSTTSSSTVQQDTKSLKEVLRLLRCLILFMESPVFAGLKEQ----IRQ---------RIE--L 771

  Fly   849 RRSGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMR 913
            ...|....|||.| ..::..::|....|         ||...|..:...:::    .|:||:.:.
 Worm   772 LGDGEQKIPISKI-KWSLETAISMICQN---------APDATEETTSLEEFL----NLLRIMILG 822

  Fly   914 QEEIINC----------ICEYGE------EDGLMIQCELCLC 939
            .:|.::.          |.|:..      .|.:.:..|:.:|
 Worm   823 LQEPVHLQPILQKLDQKINEFARNDRKIASDKIRVVIEMIIC 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	5..84	CDD:461662	18/75 (24%)
		MBT_PHF20L1-like	215..282	CDD:439094	10/68 (15%)
		Tudor_PHF20-like	288..337	CDD:410457	10/50 (20%)
		MeCP2_MBD	449..522	CDD:238690	8/74 (11%)
		PHD_SF	919..963	CDD:473978	5/37 (14%)
		PRK04778	<1099..>1153	CDD:179877
set-24	NP_496579.3	SET_SETD5-like	40..162	CDD:380927	21/136 (15%)
		SPK	243..354	CDD:214732	25/140 (18%)
		SPK	530..632	CDD:461308	21/106 (20%)