DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and phf20l1

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_009290756.1	Gene:	phf20l1 / 327626	ZFINID:	ZDB-GENE-030131-5837	Length:	1116	Species:	Danio rerio

Alignment Length:	1229	Identity:	261/1229 - (21%)
Similarity:	424/1229 - (34%)	Gaps:	401/1229 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 KYSNPHNLT--IGARLEALSVEGNWLPARIVEVNETEQTLLVRFER-NHKLKVSPSTSGSFQEWM 269
            |..|...:|  :|||:||......|.|:||.:::..|..:||.|:| :|:          :.||:
Zfish     4 KTPNRPGITFEVGARVEAQDYLQKWYPSRIEKIDYDEGKMLVHFDRWSHR----------YDEWI 58

  Fly   270 AIKSERLR------------------QRLSN------RVLPVF---------------EL--DEK 293
            ...|.|||                  :|||.      |.||..               ||  .|:
Zfish    59 LWDSNRLRPLERPALRKEGLKEEEVSERLSEMRASRLRELPGSTESTEDQKDLPQQRQELRDGEE 123

  Fly   294 CMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQL----------------- 341
            .:|||:..|.:|..|..:....||.|.|.||.::.|:.:|:..||:..
Zfish   124 VLARWTDCRYYPAKIESINKEGTYTVQFYDGVIRCVKRIHIKSMPEDAKGQQDWIALVKAASAAA 188

  Fly   342 ----------------------------------------------------------------- 341

Zfish   189 KNKGGNRPRTSANSNKDREDRREQRSDEEEDDDDADEDDDDDDDDDGEEEEEEEDSESEKLADLD 253

  Fly   342 -------PPVQVAEE-------------------------GASKSPTPVGTPVSSAPVAPKRAST 374
                   ||.:..|.                         |.:.:.|.:.......||.|::
Zfish   254 SEEEDSKPPAEELESAIAKRRSKRQGNQCSIKRSRLGKGAGCADTETELKAETKELPVTPQQ--- 315

  Fly   375 GSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLP--------EIPHDGEWTCHWVNDQP 431
             .:.....|...:||:....::..|          ||..|        .:.||...:.....:.|
Zfish   316 -KVPSPEPSPADEKSQSVSAQKTTP----------SLSNPPACKARSRRLKHDSGESASSCQNTP 369

  Fly   432 IGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLE 496
            ...|...:....|         .||                 |....:||....|.:...:|...
Zfish   370 AAPESSPLPSPTQ---------TLP-----------------DSTHTAPSSSPQRRRRSQRLATT 408

  Fly   497 SQNLVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPK-PRPMDVSMNSTLDQSITSQHSLPST 560
            | :|:..|     |.|.|...       ||   |.|||. |...|...::.:.....||..:..:
Zfish   409 S-DLICPP-----SPHTRDTA-------TH---PTPPPDGPLIADEDSSTVVKTEAISQKPVSES 457

  Fly   561 P----------MPVKESQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLM- 614
            |          .|:.|.:.|...:.|.....|..||...||  ...|:.:...:|::.....::
Zfish   458 PSTATSTASAQAPITEKEKMNDVLPSNQAALEGNSPAVVPA--AIQKVPSRTPKANKHAREPIIN 520

  Fly   615 --LADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYH---KEFAEHVSH 674
              .:|..:..|...      :.:..|.:.|....|:|.:||...|..|:::||   ||....|
Zfish   521 TKRSDDPLAPNECI------IDLDHNKFKCKVSGCSKAFRKAKLLDYHLKYYHNTEKEMDTEV-- 577

  Fly   675 CPKMQELAVKRTHPS-SIDQVEAVPKNQ----------IPNQQFFAKMHQQDLQQSRSFKRQSVS 728
            |...:|...:.|..| ....:..||.|:          :.:|.|..:|......:...|.::..|
Zfish   578 CSPEREGRTRATSASMPTSTLSDVPDNKRRRTVSTSSSLSSQGFMLQMDSGGCVRPSKFCKKKRS 642

  Fly   729 ATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDA---GPTQSFNPSLSRSCKRAR 790
            :.:.||..::::          .||.....:...|.::|..||.   ...:.|  .|...|   :
Zfish   643 SASMSSDSTEVS----------LPPPTFDNLHDKIIKKDKHLDGLCIKTERKF--KLDDKC---Q 692

  Fly   791 LSPSKRPSGSR-----------KSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPDTRI 844
            |...||....|           :..:::.:::..|...|        |::|...::.     .|.
Zfish   693 LFVKKRDKDRRDRKEKDLFRIKQKKKKKKKKKSKLHCYP--------DLDEMSLAYL-----ERP 744

  Fly   845 DSKKRRSGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRI 909
            .|...||.::....|:...|....||.....| .:||: .|.....|:|..:.....::.:.|.:
Zfish   745 SSPPHRSSSSAFKHSTFQYPRAILSVDLTGEN-LSDID-FLEDSTTESLLFSGDEYNQDLDSITM 807

  Fly   910 VRMRQE------EIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQR 968
            ...:.|      ||:.||||..||:|.|||||.|:||||..|.|::::: :|::|:|||||:|..
Zfish   808 EDFQDEDDDGADEIVRCICEMDEENGFMIQCEECMCWQHSVCMGLLEDS-IPEQYICYICRDPPG 871

  Fly   969 GRDSMRFKHDQDWLFEGK---LPVAAYHTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKI 1030
            .|.|.:::||:|||.:|.   |...|.:.::..|.|    :..:|.|..::...|..:|.|.:|:
Zfish   872 QRWSAKYRHDKDWLQKGHMYGLSFLAENYSHQNAKK----IVSTHQLLADVYSVKNLLHGLQLKM 932

  Fly  1031 NIARNRCHPKLYLWAKKW---DED----------------NLDSTALT-----------PVKRAK 1065
            :|.:|:.:|.|:|||:.|   |||                |.:|...|           |...|:
Zfish   933 DILQNKHNPSLHLWARSWVNSDEDQPMGGVPDGLHFKEHLNQNSNPETYITSEHSYQKPPGTGAE 997

  Fly  1066 -------LEAPDLPNVPQPE--AAIDPEEC---------------QYRLIEHIKVQQSLVLDRLN 1106
                   ::.....|:.:.|  :||....|               |..|:.||:       |..|
Zfish   998 HTRDEQGMQMGSQFNIKEEEVSSAIALSGCVNDSSVEQTRNCLQWQMNLLTHIE-------DIQN 1055

  Fly  1107 DIEAEMDELEKEDTLDDLKDADISTTKEALATFIKELETMKRLAKLNQV-ANMKQTLRD 1164
            .:...||.:|||  ||.|         |:...|..|||....||:|.|: ..:||.|.|
Zfish  1056 QLSGRMDLIEKE--LDVL---------ESWLDFTGELEPPDPLARLPQLKCRIKQLLTD 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	13/36 (36%)
		MeCP2_MBD	449..522	CDD:238690	13/72 (18%)
		PHD_SF	919..963	CDD:304600	23/43 (53%)
phf20l1	XP_009290756.1	MBT	3..68	CDD:327428	24/73 (33%)
		TUDOR	121..165	CDD:119391	15/43 (35%)
		DUF3776	248..323	CDD:315317	8/78 (10%)
		Atrophin-1	<312..510	CDD:331285	47/255 (18%)
		PHD_PHF20L1	823..868	CDD:277103	25/45 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574592
Domainoid	1	1.000	146	1.000	Domainoid score	I4492
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3768
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147824at2759
OrthoFinder	1	1.000	-	-		FOG0001785
OrthoInspector	1	1.000	-	-		otm25367
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15856
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X2262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.020