DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MBD-R2 and Set2

DIOPT Version :9

Sequence 1:NP_731688.2 Gene:MBD-R2 / 41498 FlyBaseID:FBgn0038016 Length:1169 Species:Drosophila melanogaster
Sequence 2:NP_572888.2 Gene:Set2 / 32301 FlyBaseID:FBgn0030486 Length:2362 Species:Drosophila melanogaster


Alignment Length:1511 Identity:271/1511 - (17%)
Similarity:441/1511 - (29%) Gaps:620/1511 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 PTVFPWGKMDTAEIEADQRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQILSESAERKA 145
            |.|.|....|  |...|:|..|..::....:...|:.|           |..:..|..|:...|.
  Fly   283 PEVEPPALQD--ENAMDERPKQEQNLSRMVDAEENSDS-----------DSQIIFIEIETESPKG 334

  Fly   146 TEEGKTGKAAD-------DV-------KNTPESGEDANKAAAKEPSGTPVAASS--------EAT 188
            .||.:.|:..:       |:       :.||:..||.::...:..||.|...|:        :||
  Fly   335 EEEQEEGRPVEVEPQDLIDIDMELAKQEPTPDPEEDLDEIMVEVLSGPPSLWSADDEAEEEEDAT 399

  Fly   189 V---------PAPGSASSS------NSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPARIVEV 238
            |         ||..|.||:      ::||.|     |:....|:......::.|.:   .:|:|.
  Fly   400 VQRATPPGKEPAADSCSSAPRRSRRSAPLSG-----SSRQGKTLEETFAEIAAESS---KQILEA 456

  Fly   239 NET----EQTLLVRF------ERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELDEK 293
            .|:    ||.:|:..      |......|||:......|.:.::..:|          |.|.||.
  Fly   457 EESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQL----------VDEADEI 511

  Fly   294 CMARWSGPRKFPGTIRKL----------LGNDTY-----------------EVLFDDGYVKNVRA 331
            ..::    ::|  .|:|:          |..|.:                 |::.:|.|:....|
  Fly   512 LDSK----QEF--VIKKVFSESDNIAASLNKDIFEPKVETKATCGEVVPRPEMVTEDVYITEGIA 570

  Fly   332 VHMNK---------------------------------------MPKQLPPVQV--------AEE 349
            ..:.|                                       :|:..|.|.:        ||.
  Fly   571 ATLEKSAVVTKPTTEMIAETKLSDEVVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEV 635

  Fly   350 GASKSP----------------------------------TPVGTPVS---SAPVAPKRASTGSL 377
            ..:.||                                  ||:.|..:   |.|.||:..::.|.
  Fly   636 ETTSSPLVPPECCTLESVSGPVLLETSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSS 700

  Fly   378 -----------GGSSGSSGSKKSKCAPQR--RDWPLLDMASLDIASLGLPEIPHDGEWTCHWVN- 428
                       ......:..:..||..|:  :..||.:|..        ||.|     ....|: 
  Fly   701 EEPNFLLEDYESNQEQVAEDEMMKCNNQKGQKQTPLPEMKE--------PEKP-----VAETVSK 752

  Fly   429 -----DQPIGTEGFLI-----VGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSP--- 480
                 :.|..:...::     .||.:|..|......:|.   |.|..:.:...      |:|   
  Fly   753 KEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPE---KKMDSKKSCAA------VTPAKQ 808

  Fly   481 --SGKRF----------RSKSDLKLFLESQNLVYNPDVYDFSIHRRRAKDINAYVYTHGYNPQ-- 531
              |||..          :.||..||...|      |:..|     ::.||      |..::||  
  Fly   809 KESGKSAKEAILKKETEKEKSSAKLDSSS------PNTLD-----KKGKD------TAQWSPQLQ 856

  Fly   532 --PPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPADET 594
              |....:|...|..|.:.::.::|      |.|.:|....:..::...||:             
  Fly   857 TLPKSSTKPPQESAPSVISKTTSNQ------PAPKEEQHAAKKGLSDNSPPS------------- 902

  Fly   595 KPKIEAEILEASEGGTSQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLI 659
                   :|:|.|...|            ||.                   :|...::..|....
  Fly   903 -------VLKAKEKAVS------------GFV-------------------ECDAMFKAMDLANA 929

  Fly   660 HIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKR 724
            .:|...|       :..|::::..|...|..::...|||   :|.|       ::.|....|.:|
  Fly   930 QLRLDEK-------NKKKLKKVPTKVEAPPKVEPPTAVP---VPGQ-------KKSLSGKTSLRR 977

  Fly   725 QSV----------------SATATSST----PSDI-------------------------TPTK- 743
            .:|                ||.|.:|.    ||.:                         |||: 
  Fly   978 NTVYEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSSSSSTPTRE 1042

  Fly   744 -ALLSPKMEPPSVSPTVESGIKQEDVSLDAG--------------------------------PT 775
             |..|| :...|.|.:..:|.|:....||.|                                |.
  Fly  1043 VAASSP-VSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVPLTKRRFSMHPK 1106

  Fly   776 QSFNP--------------------SLSR------SCKRARLSPSKR------------------ 796
            .|.||                    ||||      |...::.:|.|:                  
  Fly  1107 ASANPLHDTLLQTAGKKRGRKEGKESLSRQNSLDSSSSASQGAPKKKALKSAEILSAALLETESS 1171

  Fly   797 ---PSGSRKSNRQRSQRRPIL-SDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSG----- 852
               .||| |.:|...|..|.| :.||.|      |:.:..:.........::|..:|:.|     
  Fly  1172 ESTSSGS-KMSRWDVQTSPELEAANPFG------DIAKFIEDGVNLLKRDKVDEDQRKEGQDEVK 1229

  Fly   853 -------------------AATTPISSIDSPAMGDSVSTP------------------------- 873
                               .||||..|.......||.||.                         
  Fly  1230 READPEEDEFAQRVANMETPATTPTPSPTQSNPEDSASTTTVLKELETGGGVRRSHRIKQKPQGP 1294

  Fly   874 -SSNDQTDINAALAP-PPAETLSKA-------PQYIKENGELIRIVRMRQEEIINCICEYGEEDG 929
             :|..:...:.|||| ...|.|::.       .|:::..|  :...::.:|....|..:..:|:.
  Fly  1295 RASQGRGVASVALAPISMDEQLAELANIEAINEQFLRSEG--LNTFQLLKENFYRCARQVSQENA 1357

  Fly   930 LMIQCELCLCWQHGACNGIVKEADVPDKYVCY----ICRNPQRGRDSMRFKHDQDWLFEGKLPVA 990
            .| ||:..|.....|...:...|...::.:..    :|.|..|..:. ||:..|.|      |..
  Fly  1358 EM-QCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNK-RFQQHQCW------PCR 1414

  Fly   991 AYHTANPQATKQFELL---------------------KRSHTLTGNLLDAKRSMHSLLV------ 1028
            .:.|.........|||                     :|.|     |....|:.|...:      
  Fly  1415 VFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQH-----LYSKDRNRHYYFMALRGEA 1474

  Fly  1029 ------KINIAR---NRCHPKLYLWAKKWDEDNLDSTALTPVKRAKLEAPDLPNVPQPEAAIDPE 1084
                  |.||:|   :.|.|...  .:||..:.........||         |..|..|...|  
  Fly  1475 VIDATSKGNISRYINHSCDPNAE--TQKWTVNGELRIGFFSVK---------PIQPGEEITFD-- 1526

  Fly  1085 ECQYRLIEHIKVQQSLVLDRLND---IEAEMDELEKEDTLDDLKDADISTTKEALATFIKELETM 1146
               |:.:.:.:..|....:..|.   |..|.|..|.|. ||:..|:|....:|.|....:|.:..
  Fly  1527 ---YQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQ-LDEESDSDAEMDEEELEAEPEEGQPR 1587

  Fly  1147 KRLAKLNQVANMKQTL 1162
            |. ||....:.:|..|
  Fly  1588 KS-AKAKAKSKLKAKL 1602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MBD-R2NP_731688.2 THAP 4..86 CDD:283206 2/4 (50%)
TUDOR 292..329 CDD:119391 9/63 (14%)
MeCP2_MBD 449..522 CDD:238690 17/87 (20%)
PHD_SF 919..963 CDD:304600 8/47 (17%)
Set2NP_572888.2 AWS 1358..1410 CDD:197795 11/53 (21%)
SET 1414..1533 CDD:214614 24/139 (17%)
PostSET 1535..1551 CDD:214703 2/15 (13%)
WW 2014..2043 CDD:278809
SRI 2270..2348 CDD:285448
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
11.030

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