DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and mbd3b

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_005170489.1	Gene:	mbd3b / 321217	ZFINID:	ZDB-GENE-030131-9792	Length:	265	Species:	Danio rerio

Alignment Length:	217	Identity:	43/217 - (19%)
Similarity:	76/217 - (35%)	Gaps:	60/217 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   754 SVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNP 818
            |:.||.:....:..::...|.:...:....|:.|......:|.....|..|..:|:.:|.|:
Zfish    26 SLCPTGKKFRSKPQLARSLGNSMDLSSFDFRTGKMLMSKLNKNRQRPRYDNNSQSKGKPDLN--- 87

  Fly   819 AGHGLTEQDVEETRQSFNTPT--------------PDTRIDS------KKRRSG-----AATTPI 858
                 |...|.:|...|..|.              |...||.      :|:.||     .|...:
Zfish    88 -----TSLPVRQTASIFKQPVTKVTNHPSNKVKTDPQKAIDQPRQLFWEKKLSGLNAFDIAEELV 147

  Fly   859 SSIDSP-----------------AMGDSVSTPSSNDQTDINAALAPPP------AETLSKA---- 896
            .::|.|                 |:..::.|.::.....::||:...|      |:.|.||
Zfish   148 KTMDLPKGLQGVGPGCTDKTLLSAIASALHTSAAPITGQLSAAVEKNPGVWLNTAQPLCKAFIVT 212

  Fly   897 PQYIKENGELIRIVRMRQEEII 918
            .:.|::..||:..||.|.||.:
Zfish   213 DEDIRKQEELVYSVRKRLEEAL 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600	43/217 (20%)
mbd3b	XP_005170489.1	MBD	<29..69	CDD:294079	6/39 (15%)
		MBDa	74..139	CDD:293172	15/72 (21%)
		MBD_C	144..234	CDD:290755	19/89 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900