Protein Alignment MBD-R2 and Phf20

DIOPT Version :9

• Sequence 1: NP_731688.2
• Gene: MBD-R2 / 41498
• FlyBaseID: FBgn0038016
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001101265.1
• Gene: Phf20 / 311575
• RGDID: 1305020
• Length: 1010
• Species: Rattus norvegicus
• Alignment Length: 1181
• Identity: 237/1181 - (20%)
• Similarity: 399/1181 - (33%)
• Gaps: 431/1181 - (36%)

  Fly   217 IGARLEALSVEGNWLPARIVEVNETEQTLLVRFER-NHKLKVSPSTSGSFQEWMAIKSERLR--Q 278
            :||:|||.....||.||.|.:::..|..:|:.|:| ||:          :.||....|..||  :
  Rat    15 VGAQLEARDRLKNWYPAHIEDIDYEEGRVLIHFKRWNHR----------YDEWFCWDSPYLRPLE 69

  Fly   279 RLSNRVLPV--------FELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMN 335
            ::..|...:        |:::::.:|.||..|.:|..:..:..:.||.|.|.||.|:.|:.:|:
  Rat    70 KIQLRKEGLHEEDGSSEFQINQQVLACWSDCRFYPARVTAVNKDGTYTVKFYDGVVQTVKHIHV- 133

  Fly   336 KMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRDWPL 400
                         :..||....||.      ..||.....||    .||..|:.|...||:
  Rat   134 -------------KAFSKDQNIVGN------ARPKETDHKSL----SSSPEKREKFKEQRK---- 171

  Fly   401 LDMASLDIASLGL---------PEIP-HDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRL 455
               |::::....:         |:.| .:|:.||   .::...:|..|...|.:....|.::.|.
  Rat   172 ---ATVNVKKNQVEKALKTEKRPKPPDKEGKLTC---PEKGRVSEKSLPKNEKEDKENISENERE 230

  Fly   456 PPG--WIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHRRRAKD 518
            ..|  .:....::..|....:. |..|..||.|..|.....::|.:....|    .::..||.|
  Rat   231 YSGDAQVDKKPEKDLVKSPQET-LKEPKRKRGRPPSITPTAVDSNSQTLQP----ITLELRRRK- 289

  Fly   519 INAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQ----------------------------- 554
                  ....:..|..:||   :..||:.:||....
  Rat   290 ------ISKRSDTPLKRPR---LDKNSSQEQSKKRSENSDKDLSRRRSSRLSTNGTRETLDPDLI 345

  Fly   555 -----HSLPSTPM-----------------PVKESQYMEA----PVASLMPPAEL------MSPQ 587
                 |::.:.|:                 |::..|...|    |:...:..|:|      |...
  Rat   346 VPDLVHTVDTNPLQDKSPSAKESAEGQLESPLEAGQVSSALTCHPIGDGLGAADLELNCKSMGEN 410

  Fly   588 TQPADETKPKIEAEILEASEGGTSQLMLADPHVVENGFAFIGGLKVKIQ------DNLYVCPRED 646
            |...:...|..|.:...|:|         .|:.::....|     ||:.      |:.:.|...|
  Rat   411 TMKTEPVSPPAEVQEDSAAE---------VPNTLKKAGDF-----VKLHAPAVDLDHKFRCKVVD 461

  Fly   647 CAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTH--------PSSIDQVEAVPKNQIP 703
            |.|.:||...|     |||.::...:...|:.:: ...|||        |....| |::|:.:|.
  Rat   462 CLKFFRKAKLL-----HYHMKYFHGMEKSPEPED-GSGRTHVQTRGSTVPDKASQ-ESLPRKRIS 519

  Fly   704 NQQFFAKMHQQDLQQS---------RSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTV 759
            .....||..:::.::.         :..|::............||:.|    |.:..||......
  Rat   520 ASSPTAKEKEKNKEKKFKELVRVKPKKKKKKKKKTKPECPCSEDISDT----SQEPSPPKTFAVT 580

  Fly   760 ESGIKQEDVSLDAGPTQSFNPSLS-----------RSCKRARLSPSKRPSGSRKSNRQRSQRRPI 813
            ..|...:       |....:|.|.           ::|:...||.|             |....:
  Rat   581 RCGSSHK-------PAVHMSPQLHGSDTGNHKGKLKACEEDNLSES-------------SSESFL 625

  Fly   814 LSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAMGDSVSTPSSNDQ 878
            .||...|     |||:.      |..||..::                     ||        |:
  Rat   626 WSDEEYG-----QDVDV------TTNPDEELE---------------------GD--------DR 650

  Fly   879 TDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHG 943
            .|.                                  |::.|||...||:..|||||.|.|||||
  Rat   651 YDF----------------------------------EVVRCICGVQEENDFMIQCEECQCWQHG 681

  Fly   944 ACNGIVKEADVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLPVAAYHTANPQATKQFELLKR 1008
            .|.|:::| :||:||.||:|::|...|...::.:|::||..|.:...|:...| .:.:..:.:..
  Rat   682 VCMGLLEE-NVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEEN-YSHQNAKKIVA 744

  Fly  1009 SHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNLDSTA---------------- 1057
            :|.|.|::......:|.|.:|::|.::|.||.|.||.:.|.:.:.:..|
  Rat   745 THQLLGDVQRVIEVLHGLQLKMSILQSREHPDLQLWCQPWKQHSGEGRAHSRHIHITDARSEESP 809

  Fly  1058 -----------LTPVKRAKLEA------------------------------------------- 1068
                       .:|:.|:..|:
  Rat   810 SYRTLNGAVEKPSPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVSPLCENGD 874

  Fly  1069 -PDLPNVPQP------EAAIDPE-------EC------------------------------QYR 1089
             |..|.:..|      ...|||:       ||                              |:.
  Rat   875 DPLSPRLGWPIDQDRSRGDIDPKPSSPKVRECIPKKVLLEETPARKLLDRGGEGLVSSQHQWQFN 939

  Fly  1090 LIEHIKVQQSLVLDRLNDIEAEMDELEKEDTLDDLKDADISTTKEALATFIKELETMKRLAKLNQ 1154
            |:.|::..|..|..|::.||.|:|.|  |..||                :..|||..:.||:|.|
  Rat   940 LLTHVESLQDEVTHRMDSIEKELDVL--ESWLD----------------YTGELEPPEPLARLPQ 986

  Fly  1155 VAN-MKQTLRD 1164
            :.: :||.|.|
  Rat   987 LKHCIKQLLTD 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	12/36 (33%)
		MeCP2_MBD	449..522	CDD:238690	15/74 (20%)
		PHD_SF	919..963	CDD:304600	25/43 (58%)
Phf20	NP_001101265.1	MBT	3..68	CDD:418456	21/62 (34%)
		Tudor_PHF20	87..139	CDD:410524	16/65 (25%)
		DUF3776	178..252	CDD:372226	12/76 (16%)
		PHD_SF	657..700	CDD:419867	25/43 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	214	1.000	Inparanoid score	I3544
OMA	1	1.010	-	-		QHG47145
OrthoDB	1	1.010	-	-		D147824at2759
OrthoFinder	1	1.000	-	-		FOG0001785
OrthoInspector	1	1.000	-	-		otm44897
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15856
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2262
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.000