DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and Setd5

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_017448059.1	Gene:	Setd5 / 297514	RGDID:	1310433	Length:	1478	Species:	Rattus norvegicus

Alignment Length:	1112	Identity:	217/1112 - (19%)
Similarity:	323/1112 - (29%)	Gaps:	441/1112 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LKPRVFPTVFPWG------KMDTAEIEADQR---------------------ALQHASVEGTTET 112
            |.|..|||:   |      |....|:|.:|:                     :.:|..|:...|.
  Rat   464 LPPPSFPTI---GAETRRRKARRKELEMEQQNEVPEENHDPQPQEVPEKVTVSSEHEEVDNPEEK 525

  Fly   113 PGNAQSSTNDD------VIKATVDQIVAQILS--ESAE-RKATEEGKTGKAADDVKNTPES---- 164
            |...:....||      ..:...|:.|..|:.  |:.| ||...:....::..||:.|..|
  Rat   526 PEEEKEEATDDQENSAHSRRTREDRKVEAIMHAFETLEKRKKRRDQPVEQSNSDVEITTSSSEIG 590

  Fly   165 -GEDANKAAAKEPSGTPVAASSEATVPAPGSASSSNS----------PLPGTPP-KYSNPHNLTI 217
             ||:...||.:.....||...:..::|.....::..|          |:|..|| |.|.|...:.
  Rat   591 VGEETKTAAPESEVNNPVTNIAIPSIPQSTGVNTRRSSHAGDVAAEKPVPKPPPAKPSRPRPKSR 655

  Fly   218 GARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSN 282
            .:|....|.:                    |.:|..:.....:         .:....|.:..||
  Rat   656 ISRYRTSSAQ--------------------RLKRQKQANAQQA---------ELAQAALEEGGSN 691

  Fly   283 RVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQ-- 345
            ..:.:.|         :|.....|..|.|.|:|.        .|.:|...|:|:...:.|..:
  Rat   692 NSVTLPE---------AGNIDSSGESRPLTGSDP--------TVVSVTGSHVNRAASKYPKTKKY 739

  Fly   346 -VAE---EGASKSPTPVGTPVSSAPVAPKRAST-----GSLGGSSGSSGSKK-----SKCAPQRR 396
             |.|   :.|.|...||..|:.........|:|     |.:......:..|.     |...|:||
  Rat   740 LVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFMPERR 804

  Fly   397 DWPLLDMASLDIASLGLPEIPHDGEW-TC--HWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPG 458
            ..|||.                ||.: :|  .|:...       |..|..|..:| .|:.|
  Rat   805 RRPLLP----------------DGTFSSCKKRWIKQA-------LEEGMTQTSSV-PQETR---- 841

  Fly   459 WIKHMYQ-----RSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNL--VYNPDVYDFSIHRRRA 516
             .:|:||     .|:.:.|.:..|:||. |:::|:     :|..||:  :..|
  Rat   842 -TQHLYQSNENSNSSSICKDNADLLSPL-KKWKSR-----YLMEQNITKLLRP------------ 887

  Fly   517 KDINAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKES-----QYMEAPVAS 576
                       .:|..||.|     |..|...|..|     |....|.:|.     ..|.:|:.|
  Rat   888 -----------LSPVTPPPP-----SSGSKSPQLTT-----PGQTHPGEEECRNGYSLMFSPITS 931

  Fly   577 LMPPAELMSP------QTQPADETK--------------------------------PKIEAEIL 603
            |...:...:|      ..:..|.||                                |..||...
  Rat   932 LTTASRSNTPLQFELCHRKDLDLTKVGYPDSSTHSCGDRPSLLNCSHPDLTSHPSVAPTSEAGFP 996

  Fly   604 EASEGGTSQLML--------------------ADPHV--VENGFAFIGGLKVKIQDNLYVCPRED 646
            ..|..|...|:.                    |.|..  :..|...:|..|....|..|..|.|.
  Rat   997 SRSGDGPQTLLRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSPAEG 1061

  Fly   647 CAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPK-NQIPNQQ---- 706
            .:..|                  ||    ..|::|:.....|......|.||. .|.|.|:
  Rat  1062 FSSRY------------------EH----GFMKDLSRGSMSPGGERTCEGVPSAPQNPPQRKKVS 1104

  Fly   707 --FFAKMHQQ---------DLQQSRS--------------------------------FKRQSVS 728
              .:.|..|:         |..||:|                                .|:.|.|
  Rat  1105 LLEYRKRKQEAKENSGGGSDSSQSKSKSSGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKFSPS 1169

  Fly   729 ATATSS----TPSD--------ITPTKALLSPKMEPPSV-------------------------S 756
            .::||.    :|||        ..|.:.:.|..|.|.||                         |
  Rat  1170 HSSTSHLEAVSPSDSRGTSSSHCRPQENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPS 1234

  Fly   757 PTVESGI--KQEDVSLDAGP----------TQSFNPS-------------------LSRSCKRAR 790
            ||.||.|  |:.|.:...||          ...::||                   |.:|....|
  Rat  1235 PTWESNITEKESDPADGEGPEPLSSALSKGATVYSPSRYSYQLLQCDSPRTESQSLLQQSSSPFR 1299

  Fly   791 LSPSKRPSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDS--------- 846
            ..|::.|..|.::...|       ..||..||.:|..:..|  |:.:|......||
  Rat  1300 GHPTQSPGYSYRTTALR-------PGNPPSHGSSESSLSST--SYPSPAHPVSTDSLAPFTGTPG 1355

  Fly   847 ---------------KKRR----SGAATTPISSIDSPAMGDSVS-----TPSSNDQTDINAALAP 887
                           ..||    |.|:.||....|||. .||||     |.||......:.:..|
  Rat  1356 YYSSQPHSGNSTGSNLPRRSCSSSAASPTPQGPSDSPT-SDSVSQSSTGTLSSTSFPQNSRSSLP 1419

  Fly   888 PPAETLS 894
            ....|:|
  Rat  1420 SDLRTIS 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	5/10 (50%)
		TUDOR	292..329	CDD:119391	7/36 (19%)
		MeCP2_MBD	449..522	CDD:238690	16/79 (20%)
		PHD_SF	919..963	CDD:304600
Setd5	XP_017448059.1	SET_SETD5	305..454	CDD:380958
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900