DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and Dido1

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_780760.2	Gene:	Dido1 / 23856	MGIID:	1344352	Length:	2256	Species:	Mus musculus

Alignment Length:	1341	Identity:	233/1341 - (17%)
Similarity:	389/1341 - (29%)	Gaps:	511/1341 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RCCVANCPSTSR----------LLEHNGVTY---------------------HSFPLDPIIRAIW 37
            :|....|.|.::          :|:|...|.                     ..|.|......:.
Mouse   393 KCIGPGCSSVAQPDSVYCSNDCILKHAAATMRFLSSGKEQKTKPKEKVKTKPEKFSLPKCSVQVG 457

  Fly    38 IK----NSRISLERQ--ITKSVLVCSR--------------------HFRRLDFNTIRNGKYLLK 76
            ||    :.|::.|::  ..|.|::.||                    |    ::|.::..|....
Mouse   458 IKISSVHKRLASEKRENPVKKVMLASRSETSGKEAACESSTPSWASDH----NYNAVKPEKPEKP 518

  Fly    77 PRVFPTVFPWGKMDTAEIE--------ADQRALQHASVEGTTETPGNAQSS-----TNDDVIKAT 128
            ..:.||:......|...:|        ..::||..||:.|...:|.|....     :|....|..
Mouse   519 TALSPTLLSKSMKDDRRVEDRTMAAVTIPKKALPSASLVGRQTSPRNLVPKKLPPYSNMAGAKPA 583

  Fly   129 VDQIVAQILSESAER---KATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVAASSEATVP 190
            :.::.:.......:|   .||..|.:.:.|.....|..|.:....||....:..|::|:..|..|
Mouse   584 IKKLPSGFKGTIPKRPWPSATLSGTSARQAGPTPMTAASKKLPGSAAVVGVTRKPMSANVPAASP 648

  Fly   191 APGSASSSNSPLPGTP------------------------------------------------- 206
            |||..... ||.|..|
Mouse   649 APGRLGPV-SPAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQ 712

  Fly   207 -------PKY-------SNPHNLTIGARL----------------EALSVE-GNWLPARIVEVNE 240
                   .||       .:|.|..:..|:                |.:|.| ..|.......|.|
Mouse   713 VTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSMWTEKPTKSVIE 777

  Fly   241 TEQTLLVRFERN-------HKLKVSPSTSGSFQEWMAIK--------------SERLRQRLSNRV 284
            :...||...::|       ..::.||..|.|.::..:::              |..|:...|...
Mouse   778 SRTKLLNESKKNTTKPETIPDMEDSPPVSDSEEQQESVRAAPEKSAAPLLDVFSSMLKDTTSQHR 842

  Fly   285 LPVFELDEK-CMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQVAE 348
            ..:|:|:.| |..:.......|...::.|...:.:        ::.:..|.:..|..:|  ..|:
Mouse   843 AHLFDLNCKICTGQVPSSEDEPAPKKQKLSASSKK--------EDFKPRHDSSPPNAVP--NTAD 897

  Fly   349 EGA-------SKSPTPVGT----------PVSSAPVAPKRASTGSLGGSSGSSGS---------- 386
            ||.       :..|.|..|          |.|.....|:.:|.|.|..||.|.||
Mouse   898 EGIADTLPENASEPDPESTSSLNQERKCFPESPGDSHPEPSSLGGLSPSSASGGSGVVTTVTMSG 962

  Fly   387 ---------------------KKSKCAPQRRDW--PLLDMA------------SLDIASLGLP-- 414
                                 ..|:.:..:.|.  |.|..|            |.|...|.:|
Mouse   963 RDPRTALSGSCTVTASMAAHLDNSQASETKLDMIKPALTSAVVPKSILAKPSSSPDPRYLSVPPS 1027

  Fly   415 ------EIPHDGEWTCH-------W---VNDQPIG---TEGFLIVG-----EHQKPTVIVQDWRL 455
                  ..|.:|:.|..       |   :|.|.:.   |:.:.:.|     ....|..|....|:
Mouse  1028 PSISESRSPPEGDTTLFLSRLNTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDLPDTIHIGGRI 1092

  Fly   456 PP-------GWIKHMYQRSNVLGKW-------DVILVS-----PSGKRF-------RSKSDLKLF 494
            .|       |.:|....:...|.::       :|..:|     .|..||       |...||.|.
Mouse  1093 APKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLI 1157

  Fly   495 -------------------LES--QNL---------VYNP------DVYDFSIHRRRAKDINAYV 523
                               |||  .|:         |..|      |..|....|.:.:::...|
Mouse  1158 PLSAKDPVPSKLLPFEGPGLESPRPNIILGLVICQKVKRPSSAGELDKTDEKRTRLQQEELETSV 1222

  Fly   524 Y-----------------TH------------GYNPQPPPKPRPMDVSMNSTLDQSITSQHSLP- 558
            |                 .|            |..|.|||.|.|..:.:.|:|....||..:.|
Mouse  1223 YPKVTAALPSEKKPPKYSVHSIDTAATSTTPPGSPPPPPPLPEPPVLKILSSLKPGSTSTVTAPT 1287

  Fly   559 -----STPMPV-----KESQYMEAPVASLMPPAELMSPQ--------TQPADETKPKIEAEILEA 605
                 :|..||     |.:..:|..:.:|....:...|.        ..|..::|.|
Mouse  1288 TAAITTTASPVTAATSKTASPLEHILQTLFGKKKSFEPSGKESVGSTLSPHQDSKAK-------- 1344

  Fly   606 SEGGTSQLMLADPHVVENG-FAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFA 669
            .|...|...|.||.|.:.| |:....|:.:.:|:....|.|:    |..:       |.:|...|
Mouse  1345 GEDTMSAAPLLDPIVQQFGQFSKDKALEEEEEDDRPYDPEEE----YNPD-------RAFHTLLA 1398

  Fly   670 E--------HVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPN---------------------- 704
            |        .||...:.:|:|......:.:::.: |..:.:||
Mouse  1399 EPGRPHDVQSVSETAEREEVAYDPEDETILEEAK-VTIDDLPNRMCMKVSATERPADFTTDASSA 1462

  Fly   705 -----QQFFAKMHQQDLQQSRSFKRQSVS----ATATSSTPSDITPTKALLSPKMEPPSVS---- 756
                 |:...::::|..:|.|..:.|..:    ..|...:.:..:.:.||:||   ||..|
Mouse  1463 SLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSP---PPKSSLGKT 1524

  Fly   757 ---------PTVESGIKQEDVSLDAGPTQSFNPSLSR----------SCKRARLSPSKRPSGSRK 802
                     |....|....:.:||:  .||.:|..:|          |..||....:..|.|:..
Mouse  1525 ELFSQEQQAPDPSQGAPNTNHNLDS--RQSRDPRQARRLAAENTENESLPRAPTGSTPGPQGTLP 1587

  Fly   803 SNRQRSQRRPILSDNPAGHGLTEQD--VEETRQSFNTP---------TPDTRIDSKKRRSGAATT 856
            :.           :.|||..:.:..  ..|.::|...|         .|:..|...:......:.
Mouse  1588 AR-----------ETPAGTAVVQGPGLAAEAKESMAVPWAPGENAVLRPEHDIQKCEHPGNPVSL 1641

  Fly   857 PISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAP 897
            |:.:...|..||..:.|:             ||...|...|
Mouse  1642 PLDTSHLPTAGDGAARPA-------------PPRRVLLPTP 1669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	21/138 (15%)
		TUDOR	292..329	CDD:119391	4/37 (11%)
		MeCP2_MBD	449..522	CDD:238690	24/134 (18%)
		PHD_SF	919..963	CDD:304600
Dido1	NP_780760.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..256
		TNG2	<157..299	CDD:227367
		Nuclear localization signal. /evidence=ECO:0000255	162..170
		Nuclear localization signal. /evidence=ECO:0000255	182..190
		PHD_DIDO1_like	263..316	CDD:277109
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..535		8/57 (14%)
		PHA03247	<483..663	CDD:223021	37/184 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..624		7/25 (28%)
		PRK14954	<600..>665	CDD:184918	19/65 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	641..668		10/27 (37%)
		TFS2M	669..770	CDD:128786	9/100 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..822		7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..970		22/123 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1039		5/27 (19%)
		SPOC	1045..1190	CDD:369497	25/144 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1197..1218		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1288		12/42 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1320..1347		4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1362..1421		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1509..1609		24/115 (21%)
		PHA03247	<1571..2083	CDD:223021	21/123 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1630..2256		9/53 (17%)
		SF-CC1	2142..>2180	CDD:273721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030