DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and Setd2

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_036010808.1	Gene:	Setd2 / 235626	MGIID:	1918177	Length:	2551	Species:	Mus musculus

Alignment Length:	1097	Identity:	199/1097 - (18%)
Similarity:	330/1097 - (30%)	Gaps:	443/1097 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VANCPSTSRL---LEHNGVTYHSFPLDPIIRAIWI--------KNSRISLERQITKSVLVCSRHF 60
            :.|..|.|.|   ||.:|::           .:||        :.|...|:.:|.|:
Mouse  1746 IQNTHSQSCLKSFLERHGLS-----------LLWIWMAELGDGRESNQKLQEEIIKT-------- 1791

  Fly    61 RRLDFNTIRNGKYLLKPRVFPTVFPWGKMDTAE---IEADQRALQHASVEGT-TETPG-NAQSST 120
              |:...|.....|.:.:|.|.:..|.:..||.   .|.|..:.::.|...| ..||. :|:.||
Mouse  1792 --LEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPQLSEGDGYSSENTSRAHTPLNTPDPSAKPST 1854

  Fly   121 NDD--------------VIKATVDQIVAQILSESAERKATEEGKTGKA-ADDVKN-TPESGEDAN 169
            ..|              :.:.::|..|:.:.||.       |.|.||. .|.::. |.|..|:..
Mouse  1855 EMDTDTPKKLIFRRLKIISENSMDSAVSDVTSEL-------ECKDGKEDLDQLETVTVEEDEELQ 1912

  Fly   170 KAAAKEPSGTPVAASSEATVPAPGSASSSNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPAR 234
            ...............||||:......:|.......|.||.||      |.:||....|..  |::
Mouse  1913 SQQLLPQQLCESKVESEATIEVSKLPTSEPEADTETEPKDSN------GTKLEETIAEET--PSQ 1969

  Fly   235 IVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELDEKCMARWS 299
            ..|...::                            ::||| .|...::.:.:.:|..|.:..|
Mouse  1970 DEEEGVSD----------------------------VESER-SQEPPDKTVDISDLATKLLDSW- 2004

  Fly   300 GPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQ---VAEEG----ASKSPTP 357
                                       |:::.|:  ::||:....:   |||.|    |.:..|.
Mouse  2005 ---------------------------KDLKEVY--RIPKKSQTEKESTVAERGRDAAAFRDQTA 2040

  Fly   358 VGTPVSSAPVAP--------KRASTGSLG--GSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLG 412
            ..||..|....|        ||...|||.  .|:...|:|:
Mouse  2041 PKTPNRSRERDPDKQSQNKEKRKRRGSLSPPSSAYERGTKR------------------------ 2081

  Fly   413 LPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVIL 477
                |.|                      .:..||
Mouse  2082 ----PDD----------------------RYDTPT------------------------------ 2090

  Fly   478 VSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHRRRAK------------DINAYVYTH---- 526
               |.|:.|.|...||..|.:..::..:|......:::.:            |...|..:|
Mouse  2091 ---SKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPFDSLGYNASHHPFA 2152

  Fly   527 GYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPA 591
            ||   ||..|      |.:.:|         ||.|...|           ::.|...|.|...||
Mouse  2153 GY---PPGYP------MQAYVD---------PSNPNAGK-----------VLLPTPSMDPVCSPA 2188

  Fly   592 --DETKPKIEAEILEASEGGTSQLMLAD------PHVVENGFAFIGGLKVKIQDNLYVCPREDCA 648
              |..:|.:         |.:::.:.|.      |||..:         |::..:.||...|...
Mouse  2189 PYDHAQPLV---------GHSTESLAAPPSVPVVPHVAAS---------VEVSSSQYVAQNESVV 2235

  Fly   649 KTYRKEDFLLIHIRHYHKEFAEHVSHCPKM--------------------QELAVKRTHPSSIDQ 693
                            |::     |:.|.|                    |.::|::.:..:..|
Mouse  2236 ----------------HQD-----SNVPVMPVQAPGPVQGQNYNVWESNQQSVSVQQQYSPAQSQ 2279

  Fly   694 VEAVPKNQI----------------PNQQFFAKMHQQDLQQSRSFKR--QSVSATATSSTPSDIT 740
            .....:.|.                |..|.:|:...|.:|..:.|..  |.|....|::..|.:.
Mouse  2280 TTIYYQGQTCSTVYSVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPTAAVTSIVA 2344

  Fly   741 PTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPS---LSRSCKRARLSPSKRPSGSRK 802
            |.:   ...::||.:..|        :..||..|.....|.   |..:.|.||
Mouse  2345 PGQ---PQSLQPPEMVVT--------NNLLDLPPPSPPKPKTIVLPPNWKTAR------------ 2386

  Fly   803 SNRQRSQRRPILSDNPAG-----HGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSID 862
                          :|.|     |.:|.|      ..::.||.::..|.            :|::
Mouse  2387 --------------DPEGKIYYYHVITRQ------TQWDPPTWESPGDD------------ASLE 2419

  Fly   863 SPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEE 927
            ..|..| :.|| :.|:..:..:..|..||. ..:.:..|::.|:.|  :...:.|:.|:..|.:.
Mouse  2420 HEAEMD-LGTP-TYDENPMKTSKKPKTAEA-DTSSELAKKSKEVFR--KEMSQFIVQCLNPYRKP 2479

  Fly   928 D---GLMIQCE----LCLCWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSMRFKH 977
            |   |.:...|    |.....||..|   ||.    ||    |:||:....:...||
Mouse  2480 DCKVGRITTTEDFKHLARKLTHGVMN---KEL----KY----CKNPEDLECNENVKH 2525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	18/89 (20%)
		TUDOR	292..329	CDD:119391	3/36 (8%)
		MeCP2_MBD	449..522	CDD:238690	9/84 (11%)
		PHD_SF	919..963	CDD:304600	13/50 (26%)
Setd2	XP_036010808.1	AWS	1483..1537	CDD:197795
		SET_SETD2	1537..1678	CDD:380949
		WW	2378..2407	CDD:395320	9/60 (15%)
		SRI	2454..2542	CDD:400510	22/85 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030