DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and Setd1a

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_821172.2	Gene:	Setd1a / 233904	MGIID:	2446244	Length:	1716	Species:	Mus musculus

Alignment Length:	1155	Identity:	214/1155 - (18%)
Similarity:	328/1155 - (28%)	Gaps:	441/1155 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 GEDANKAAAKEPSGTPVAASSEATVPAP-------------------GSASSSNS----PLP-GT 205
            |:....|:|..|.|    |..||.:|.|                   |..|.|..    ||| ..
Mouse   711 GKGLTAASAGPPGG----AFGEAFLPFPPPQEAAYGLPYALYTQGQEGRGSYSREAYHLPLPMAA 771

  Fly   206 PPKYSN---------PHNLTIGARLEALSVEGNWLPA-----RIVEVNETEQTLLVRFERNHKLK 256
            .|..|:         ||      |.||...|...||:     |::.....|...:::.:.|.|:
Mouse   772 EPLPSSSVSGEEARLPH------REEAEIAESKVLPSAGTVGRVLATLVQEMKSIMQRDLNRKM- 829

  Fly   257 VSPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELDEKCMARWSGPRKF----PGTIRKLLGNDTY 317
            |.....|:|.:|...|.|:.:.         |:...|..|:.....|.    ||.:.
Mouse   830 VENVAFGAFDQWWESKEEKAKP---------FQNAAKQQAKEEDKEKMKLKEPGMLS-------- 877

  Fly   318 EVLFD---DGYVKNVRAVHMN-------KMP----KQLPPVQVAEEGASKSPTPVGTPVSSAPVA 368
              |.|   .|.:..:.|....       ::|    |:..|.:::|....|.|.| .||.......
Mouse   878 --LVDWAKSGGITGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRP-STPAEEDEDD 939

  Fly   369 PKRASTGSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIG 433
            |:|...   .|..|..|:|     |.:||
Mouse   940 PEREKE---AGEPGRPGTK-----PPKRD------------------------------------ 960

  Fly   434 TEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQ 498
            .|.....|:|:|...:..:.       :...|.|             |.::.....|     |.:
Mouse   961 EERGKTQGKHRKSFTLDSEG-------EEASQES-------------SSEKDEDDDD-----EDE 1000

  Fly   499 NLVYNPDVYDFSIHRRRAKD-----------INAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSIT 552
            ......:..|.:.....|.|           .:.|..:.|.|............|.:|:...|.:
Mouse  1001 EDEEQEEAVDATKKEAEASDGEDEDSDSSSQCSLYADSDGENGSTSDSESGSSSSSSSSSSSSSS 1065

  Fly   553 SQHSLPSTPMPVKESQYMEAPVASLMPPAELMSPQTQPADETKPK----IEAEILEASEGGTSQL 613
            |..|..|:     |.:...|.:.|..||.|:  |:..||.:.||:    :::.::..||..|...
Mouse  1066 SSSSESSS-----EEEEQSAVIPSASPPREV--PEPLPAPDEKPETDGLVDSPVMPLSEKETLPT 1123

  Fly   614 MLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKM 678
            ..|.|                                                  ||........
Mouse  1124 QPAGP--------------------------------------------------AEEPPPSVPQ 1138

  Fly   679 QELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTK 743
            .........|.:..:::..|.:.||            |......:|::||.:|....|.....|.
Mouse  1139 PPAEPPAGPPDAAPRLDERPSSPIP------------LLPPPKKRRKTVSFSAAEEAPVPEPSTA 1191

  Fly   744 ALLSPKMEPP---SVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNR 805
            |.|..|...|   .|...||..|:  ::.||       :.||.:|.      |.:...|.|  ||
Mouse  1192 APLQAKSSGPVSRKVPRVVERTIR--NLPLD-------HASLVKSW------PEEVARGGR--NR 1239

  Fly   806 QRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPA--MGD 868
            ...:.|....:.....| ||.|:........||.          |.|.||.|... ||.|  ..|
Mouse  1240 AGGRVRSTEEEEATESG-TEVDLAVLADLALTPA----------RRGLATLPTGD-DSEATETSD 1292

  Fly   869 SVSTPS---SNDQTDINAALA--PPPAETLSKAPQYIKENGELIRIVRMRQEEIINCICEYGEED 928
            ....||   |:...:.|.|||  |||.   :.||:.::....|..:.....:|::.
Mouse  1293 EAERPSPLLSHILLEHNYALAIKPPPT---TPAPRPLEPAPALAALFSSPADEVLE--------- 1345

  Fly   929 GLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNP-QRGRDSMRFKHDQDWLFEGKLPVAAY 992
                           |...:|.||:.|.:.:..  ::| |.|.:.   :.|::...|.....::.
Mouse  1346 ---------------APEVVVAEAEEPKQQLQQ--QHPEQEGEEE---EEDEEEESESSESSSSS 1390

  Fly   993 HTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNLDSTA 1057
            .:....|.::..|  ||||                      |.|
Mouse  1391 SSDEEGAIRRRSL--RSHT----------------------RRR--------------------- 1410

  Fly  1058 LTPVKRAKLEAPDLPNVPQPEAAIDP--------------------EECQY-RLIEHIKVQQSLV 1101
                      .|.||..|.|..:.:|                    |:..| ||.....:||:..
Mouse  1411 ----------RPPLPPPPPPPPSFEPRSEFEQMTILYDIWNSGLDLEDMSYLRLTYERLLQQTSG 1465

  Fly  1102 LDRLND---IEAEMDEL--------------------------------EKEDTLD-------DL 1124
            .|.|||   ::..:..|                                ||:..||       .|
Mouse  1466 ADWLNDTHWVQHTITNLSTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQL 1530

  Fly  1125 KDADISTTKEALATFIKELETM-----------KRLAKLNQVANMKQTLR 1163
            :..|...|...|:....|...:           ..|.||||:...|:.||
Mouse  1531 EGGDTQGTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLR 1580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	8/43 (19%)
		MeCP2_MBD	449..522	CDD:238690	8/83 (10%)
		PHD_SF	919..963	CDD:304600	5/43 (12%)
Setd1a	NP_821172.2	RRM_Set1A	92..186	CDD:240992
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..367
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..670
		Topoisomer_IB_N	<835..>883	CDD:322080	13/66 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..869		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1206		71/433 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1230..1259		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1275..1297		8/22 (36%)
		HCFC1-binding motif (HBM). /evidence=ECO:0000250\|UniProtKB:O15047	1307..1311		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1355..1427		19/131 (15%)
		Interaction with CFP1. /evidence=ECO:0000250\|UniProtKB:O15047	1424..1459		5/34 (15%)
		N-SET	1434..1571	CDD:314603	23/136 (17%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000250\|UniProtKB:O15047	1459..1546		15/86 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1480..1508		1/27 (4%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000250\|UniProtKB:O15047	1501..1506		0/4 (0%)
		SET	1577..1700	CDD:214614	2/4 (50%)
		PostSET	1700..1716	CDD:214703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030