DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and Phf13

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_766293.2	Gene:	Phf13 / 230936	MGIID:	2446217	Length:	296	Species:	Mus musculus

Alignment Length:	254	Identity:	60/254 - (23%)
Similarity:	97/254 - (38%)	Gaps:	59/254 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   748 PKMEPP---SVSPTVESGIKQEDVSLDAG--------PTQSFN---PSLSRSCKRARLSPSKRPS 798
            ||.|.|   |.||...:....:....|.|        |.:.|:   |||.:..|.:.....::.:
Mouse    45 PKEELPLRSSPSPANSTAGTIDSDGWDTGFSDITPSVPDRCFSHLQPSLLQRAKPSNYLLDRKTT 109

  Fly   799 GSRKSNRQRSQRRPILSDNPAGHGLTEQ--DVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSI 861
            ...|..::|.:|.   ||.|...|..|.  .:|.......||:..|..|..:    |:..|.|..
Mouse   110 DKLKKKKRRKRRD---SDIPVKEGFRESLLKLEAADPYVETPSSPTMQDIPQ----ASADPCSGW 167

  Fly   862 DS--PAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQE--------- 915
            ||  |:.| |.:|.|.:..|:|.           ::..:.|...|   :.|..|.|
Mouse   168 DSDTPSSG-SCATVSPDQVTEIK-----------TEGKRTIVRQG---KQVVFRDEDSTGNDEDI 217

  Fly   916 ---------EIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRN 965
                     :::.|.|........||:|..|..|.|.:| ..:::::||:.:||..||:
Mouse   218 MVDSDDDSWDLVTCFCMKPFAGRPMIECNECHTWIHLSC-AKIRKSNVPEVFVCQKCRD 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600	13/43 (30%)
Phf13	NP_766293.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..73		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..126		6/31 (19%)
		Nuclear localization signal. /evidence=ECO:0000250	106..123		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..183		14/42 (33%)
		PHD_PHF13	228..274	CDD:277102	13/46 (28%)
		Interaction with trimethylated histone H3 (H3K4). /evidence=ECO:0000250	237..244		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900