DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and Setd1b

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_006530300.1	Gene:	Setd1b / 208043	MGIID:	2652820	Length:	1986	Species:	Mus musculus

Alignment Length:	1002	Identity:	182/1002 - (18%)
Similarity:	285/1002 - (28%)	Gaps:	444/1002 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KMDTAEIEADQRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQILSESAERKATEEGKTG 152
            :|...|:|.....:....:||:.|.|.....:|..|:           :||.....:.|||.:
Mouse  1262 EMQAPELEEPPLPMGARKLEGSPEPPEEPGPNTQGDM-----------LLSPELPARETEEAQ-- 1313

  Fly   153 KAADDVKNTPESGEDANKAAAKEP----------------------------------------- 176
                 :.:.||.|.:::.....||
Mouse  1314 -----LPSPPEHGPESDLDMEPEPPPMLSLPLQPPLPPPRLLRPPSPPPEPETPEPPKPPVPLEP 1373

  Fly   177 ------------SGTPVAASSEATVPA-PG-----SASSS----NSP-LPGTPPKYSNPHNLTIG 218
                        .|:...:.|..|||| ||     |.|||    :|| :||:|..|.:|.
Mouse  1374 PPEDHPPRTPGLCGSLAKSQSTETVPATPGGEPPLSGSSSGLSLSSPQVPGSPFSYPSPS----- 1433

  Fly   219 ARLEALSVEGNWLPARIVEVNETEQTLLVRFERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSNR 283
               ..||..|  ||.                        :|....||.......|..|
Mouse  1434 ---PGLSSGG--LPR------------------------TPGRDFSFTPTFPEPSGPL------- 1462

  Fly   284 VLPVFEL-----DEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGY---------------VKN 328
            :|||..|     ||:     :||...|             ||.:.|.               |..
Mouse  1463 LLPVCPLPTGRRDER-----TGPLASP-------------VLLETGLPLPLPLPLPLPLALPVPV 1509

  Fly   329 VRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAP 393
            :||  ..:.|.||||:.    .|:.:|.|  ||:...|..|:|:..
Mouse  1510 LRA--QPRPPPQLPPLL----PATLAPCP--TPIKRKPGRPRRSPP------------------- 1547

  Fly   394 QRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPG 458
                    .|.|||                            |.|:              |.|||
Mouse  1548 --------SMLSLD----------------------------GPLV--------------RPPPG 1562

  Fly   459 WIKHMYQRSNVLGKWDVILV--SPSGKRFRSKSD---LKLFLESQNLVYNPDVYDFSIHRRRAKD 518
                     ..||: |::|:  .|....|.|..|   :.|...:..:...|....
Mouse  1563 ---------PALGR-DLLLLPGQPPAPIFPSAHDPRAVTLDFRNTGIPAPPPPLP---------- 1607

  Fly   519 INAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQ---HSLPSTPM------------------ 562
                       |||||.|.|..|.......:.:.:|   .::|..|.
Mouse  1608 -----------PQPPPPPPPPPVESTKLPFKELDNQWPSEAIPPGPRRDEVTEEYVDLAKVRGPW 1661

  Fly   563 ---PVKESQYMEAPVAS--LMPPAELMSPQTQPADETKPKIEAEILEASEGG-----------TS 611
               |.|..:.:.||.||  ..||..|..|:::..:.|      .:.:...||           |.
Mouse  1662 RRPPKKRHEDLVAPSASPEPSPPQPLFRPRSEFEEMT------ILYDIWNGGIDEEDIRFLCVTY 1720

  Fly   612 QLMLADPHVVENGFAFIGGLKVKIQDNLYV---CPREDCAKTYRKEDFLLIHIRHYHKEFAEHVS 673
            :.:|..    :||..:       :.|.|:|   ......||..::||.:           .|||:
Mouse  1721 ERLLQQ----DNGMDW-------LNDTLWVYHPSTSLSSAKKKKREDGI-----------REHVT 1763

  Fly   674 HCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSD 738
            .|.:                          ::.|:....:..|:...|      |..:|...|.|
Mouse  1764 GCAR--------------------------SEGFYTIDKKDKLRYLNS------SRASTDEPPMD 1796

  Fly   739 ITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPS---KRPSGS 800
                                     .|:.:|:.|.|..|......|..::.||..|   ...|..
Mouse  1797 -------------------------TQQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDL 1836

  Fly   801 RKSNRQRSQRR------------------PILSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSK 847
            .|.|:.:.:::                  ||.:|        |..:|...|:......|.| :.:
Mouse  1837 LKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAAD--------EMVIEYVGQNIRQVIADMR-EKR 1892

  Fly   848 KRRSGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPP------PAETLSK----APQYIKE 902
            ....|..::.:..:|...:.|  :|...|....||.:..|.      ..|:..|    :.|:|..
Mouse  1893 YEDEGIGSSYMFRVDHDTIID--ATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINV 1955

  Fly   903 NGELIRIVRMRQEEI-INCICEYGEED 928
            |.|:....:...|:: |.|:|  |.|:
Mouse  1956 NEEITYDYKFPIEDVKIPCLC--GSEN 1980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	8/51 (16%)
		MeCP2_MBD	449..522	CDD:238690	14/77 (18%)
		PHD_SF	919..963	CDD:304600	4/10 (40%)
Setd1b	XP_006530300.1	RRM_Set1B	100..192	CDD:240993
		N-SET	1698..1841	CDD:371711	36/227 (16%)
		SET_SETD1	1835..1982	CDD:380946	30/159 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030