DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and Ash1l

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_619620.3	Gene:	Ash1l / 192195	MGIID:	2183158	Length:	2958	Species:	Mus musculus

Alignment Length:	1618	Identity:	303/1618 - (18%)
Similarity:	505/1618 - (31%)	Gaps:	627/1618 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 STSRLLEHNGVTYHSFPLDPIIRAIWI----------------KNSRISLERQITKSVLVCSRHF 60
            :|||....:..||.|.|  |.:...|:                :..::|::...::|||...:.:
Mouse  1452 TTSRTPLLSMSTYPSVP--PEMAYGWMVEHKHRHRHKHREHRSEQPQVSMDSGSSRSVLESLKRY 1514

  Fly    61 RRLDFNTIRNG-KYLLKPRVF---PTVFP----------WGKMDTAEIEADQRALQ--------- 102
             |...:|:.:. |:..|.|..   |.:.|          |...:.:|..:....||
Mouse  1515 -RFGKDTVGDRYKHKEKHRCHMSCPHLSPSKNLINREEQWVSREPSESSSLALGLQTPLQIDCSE 1578

  Fly   103 ---HASVEGTTETPGNAQSSTNDDVIKATVDQIVAQILSESAERKATEEGKTGKAADDVKNTPE- 163
               ..|:.|.|.....|.|..:.::..:.:........:.|..:|.|:........|...|.|.
Mouse  1579 SSPSLSLGGFTPNSEPASSDEHMNLFTSAIGSCRVSNPNSSCRKKLTDSPGLFPVQDTALNRPHR 1643

  Fly   164 -----SGEDA--NKAAAKEPSGTPVAASSEATVPAP----GSASSSNSPLPGTPPKYSNPHNLTI 217
                 |.|.|  :.|.::..|..|...|||:|..:|    .|:.|::|.:.|.|.:
Mouse  1644 KEPLPSSERAIQSLAGSQSASDKPSQRSSESTNCSPTRKRSSSESTSSTVNGVPSR--------- 1699

  Fly   218 GARLEAL---SVEGNWLPARIVEVNETEQTLLVRFERNHKLKVS-----PSTS--GSFQEWMAI- 271
            ..||.|.   ||:.  |..|||..:|.|.     .|:|....::     ||:|  .|:.:..|:
Mouse  1700 SPRLVASMDDSVDS--LLQRIVHHDEQES-----MEKNGDASITTVSAPPSSSPGHSYSKERALG 1757

  Fly   272 KSERL------RQRLSNRVLPVFELDEKCMARWSGPRKFPGTI--------RKLLGNDTYEVLFD 322
            ||:.|      ....||  :|:  |.||..:|.| |.....::        ||:...|  ::|
Mouse  1758 KSDSLLVPAVPNDSCSN--IPL--LSEKSASRCS-PHHIKRSVVEAMQRQARKMCNYD--KIL-- 1813

  Fly   323 DGYVKNVRAVHMNKM-----------------------PKQLP--------PVQVAE-------E 349
             ...||:.  |:||:                       |::.|        ..|.|:       |
Mouse  1814 -ATKKNLD--HVNKILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVSPELNE 1875

  Fly   350 GASK----SPTPVGTPVSSAPVAPKRASTGSLGGSSGSS------GSKKSKCAP----QRRDWPL 400
            |...    ||..| |.|..|.|.....::....|....:      ..||.|..|    |..:...
Mouse  1876 GEDMSLHLSPDTV-TDVIEAVVQSVNLTSEHKKGVKRKNWLLEEQTRKKQKTVPEEEEQENNKSF 1939

  Fly   401 LDMASLDIAS-LGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMY 464
            :: ..::|.| |..|..|.:.|.|.     ||:..   ||..|.:.|.        ||   |..|
Mouse  1940 IE-TPVEIPSPLETPAEPSEPENTL-----QPVLA---LIPREKKAPR--------PP---KKKY 1984

  Fly   465 QRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFS-----IH-----RRRAKDI 519
            ||:.        |.|...|....||.| :.|:.:.|.|.|..:::.     ||     |::..|.
Mouse  1985 QRAG--------LYSDVYKTIDPKSRL-IQLKKEKLEYTPGEHEYGLFPAPIHVGKYLRQKRIDF 2040

  Fly   520 N-----AYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAPVASLMP 579
            .     .:.:.|....:.|..|....:..|..:|               ||.....||...:...
Mouse  2041 QLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVD---------------VKPLSGYEATTCNCKK 2090

  Fly   580 P------------------AELMSPQTQPADE--TKPKIE-------AEILEASEGG----TSQL 613
            |                  || .||.|.|..|  ...:|:       .|...|.|.|    |.:.
Mouse  2091 PDDDTRKGCGDDCLNRMIFAE-CSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEP 2154

  Fly   614 MLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEF---------- 668
            :.|...::|    ::|                   :...:::|....|..||...
Mouse  2155 LKAGQFIIE----YLG-------------------EVVSEQEFRNRMIEQYHNHSDHYCLNLDSG 2196

  Fly   669 -----------AEHVSH-CP---KMQELAVKRTHPSSIDQVEAVPKN------------QIPNQQ 706
                       |..::| |.   :||:.:|...:...:..::.:|..            .:..||
Mouse  2197 MVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQ 2261

  Fly   707 F----FAK--------------MHQQDLQQSRSFKRQSVSATA--------------TSSTPSDI 739
            .    |.|              :......||.|..|:|..|..              .|..||:.
Mouse  2262 LCKCGFEKCRGIIGGKSQRMNGLPSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSEN 2326

  Fly   740 TPTKALLSPKMEPPSVSPTVESGI----------------KQEDV---------SL--------- 770
            ..|...|:|:::...:|....:.:                |||:|         ||
Mouse  2327 INTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIHQKQEEVKHTRDIHSASLYTRWNGLCR 2391

  Fly   771 -------DAGPTQSFNPSLSRSCKRARLSPSKRP-----------------SG--SRKSNRQRSQ 809
                   |...||......:||.:..||:.::..                 .|  |.:.:.|::.
Mouse  2392 DDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENLEVARAARLAQIFKEICDGIISYRDSSQQTL 2456

  Fly   810 RRPILS--------------DNPAGHGLTEQDV----EETRQSFNT---------------PTPD 841
            ..|:|:              .:|......|:.:    .:|.::|:.               .:|.
Mouse  2457 AAPLLNLPPKKKNADYYEKISDPLDLSTIEKQILIGYYKTVEAFDADMLKVFRNAEKYYGRKSPI 2521

  Fly   842 TRIDSKKRRS--GAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENG 904
            .|...:.|::  .|.....:.||. .:|::.|...|: :|.::.                 ||:|
Mouse  2522 GRDVCRLRKAYYSARHEASAQIDE-IVGETASEADSS-ETSVSE-----------------KESG 2567

  Fly   905 ELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVC--------- 960
                  ..:.:::|.|||...:::||||||:.|:.|||..|.|:  ..|| :.|:|
Mouse  2568 ------HEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGV--NTDV-EHYLCEQCDPRPVD 2623

  Fly   961 -----------------------------------YICRNPQRGRD------------------- 971
                                               |:.|:.:|..|
Mouse  2624 REVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKL 2688

  Fly   972 ---------------------------------SMRFKHDQDWLFEGKL----PVAA-------- 991
                                             |.||.|::  ||...|    |:.|
Mouse  2689 DIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNE--LFRVPLYEIIPLEAVVGTCCVL 2751

  Fly   992 ----YHTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDN 1052
                |....|:..|:.::....:.|       .:|.| |..||:  ||| :|   :..|.:..|:
Mouse  2752 DLYTYCKGRPKGIKEQDVYICDYRL-------DKSAH-LFYKIH--RNR-YP---VCTKPYAFDH 2802

  Fly  1053 LDSTALTPVK--------------------RAKLEAPDLPNVPQPEAAIDPEECQYRLIEHIKVQ 1097
            ... .|||.:                    :::...|.|.::.|.:.|:.       |||.:...
Mouse  2803 FPK-KLTPKRDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALP-------LIEEVLAS 2859

  Fly  1098 QSLVLDRLNDIEAEMDELEKEDTLDDLKDADISTTKEALATFIKELETMKRLAKLNQV 1155
            |......:...|....|....|..|..|..:.|:.:..||:..:|....:| .:|||:
Mouse  2860 QEQAAREVPSPEEPDQERATGDIGDAEKKPEESSQEAQLASTPEERRHSQR-ERLNQI 2916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206	20/103 (19%)
		TUDOR	292..329	CDD:119391	10/44 (23%)
		MeCP2_MBD	449..522	CDD:238690	20/87 (23%)
		PHD_SF	919..963	CDD:304600	20/87 (23%)
Ash1l	NP_619620.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..137
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..580
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..843
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..963
		motB	<1061..1187	CDD:183756
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1094..1126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1149..1219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1279
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1599		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1613..1704		23/99 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1722..1754		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1921..1941		5/19 (26%)
		Catalytic domain. /evidence=ECO:0000250	2059..2278		40/257 (16%)
		AWS	2082..2133	CDD:197795	11/51 (22%)
		SET_ASH1L	2136..2276	CDD:380951	23/162 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2278..2334		10/55 (18%)
		Bromo_ASH1	2432..2537	CDD:99955	13/104 (13%)
		PHD_ASH1L	2575..2617	CDD:277023	20/44 (45%)
		BAH_polybromo	2654..2788	CDD:240068	22/145 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2814..2846		2/31 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2861..2909		9/47 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030