DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and set-12

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_509306.2	Gene:	set-12 / 187229	WormBaseID:	WBGene00019584	Length:	389	Species:	Caenorhabditis elegans

Alignment Length:	357	Identity:	64/357 - (17%)
Similarity:	117/357 - (32%)	Gaps:	120/357 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 CPR--EDCA-KTYRKEDF--------------------------LLIHIRHYHKEFAEHVSHCPK 677
            |||  .:|. :.:||..|                          |::..|......|||.....:
Worm    77 CPRGCSNCENQRFRKRQFCGVETFLTDNGIGHGLRATEEIATGKLILEYRGEAITKAEHNKRVKR 141

  Fly   678 MQELAVKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSS--TPSDIT 740
            .::..:|.::...:.:...|...:..|              |..|...|.:..|...  |..| .
Worm   142 YKKDGIKHSYSFEVGRNYYVDPTRKGN--------------SARFINHSCNPNALVKVWTVPD-R 191

  Fly   741 PTKAL--LSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRA-------RLSPSKR 796
            |.|:|  .:.|:..|.           |:::.|.|  .||.......|..|       :.|.|:.
Worm   192 PMKSLGIFASKVIKPG-----------EEITFDYG--TSFRNDQPCQCGEAACRGWIGKPSTSEV 243

  Fly   797 PSGSRKSNRQRSQRRPI-----LSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATT 856
            |....|..::|.::..:     :|....|.|      ::.:.|...|.|.:|...|::....|..
Worm   244 PKDVSKELKKRGRKPKMDPTAPISTTSTGGG------DKGKLSGTIPVPKSRRGRKRKTDVTAPV 302

  Fly   857 PISSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEIINCI 921
            |:::                 :|..::    ||||..|:..:.:|...|         |:|.|.:
Worm   303 PLAT-----------------KTKRHS----PPAENESEDKENVKPPSE---------EDITNAM 337

  Fly   922 CE-----YGEEDGLMIQCEL------CLCWQH 942
            ..     |..::|::.:|..      |..::|
Worm   338 NNLLNKTYDNQNGVLDECRSIMGNLECKSYEH 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600	6/35 (17%)
set-12	NP_509306.2	AWS	53..94	CDD:197795	6/16 (38%)
set-12	NP_509306.2	SET	97..221	CDD:214614	24/151 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030