DRSC/TRiP Functional Genomics Resources

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Protein Alignment MBD-R2 and Nsd1

DIOPT Version :9

Sequence 1:NP_731688.2 Gene:MBD-R2 / 41498 FlyBaseID:FBgn0038016 Length:1169 Species:Drosophila melanogaster
Sequence 2:NP_032765.3 Gene:Nsd1 / 18193 MGIID:1276545 Length:2691 Species:Mus musculus


Alignment Length:1445 Identity:267/1445 - (18%)
Similarity:444/1445 - (30%) Gaps:527/1445 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 ANCPSTSRLLEHNGVTYHSFPLDPIIRAIWIKNSRISLERQITKSVLVCSRHFRRLDFNTIRNGK 72
            |..|.....|...|.|..:...:|..      |:...|:.::||               |.:|| 
Mouse   108 AQSPIVCTSLSPGGPTALAMKQEPTC------NNSPELQLRVTK---------------TTKNG- 150

  Fly    73 YLLKPRVFPTVFPWGKMDTAEIEADQRALQHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQIL 137
             .|....|..|      |.|::::          |...|.|             .|.|:.:.:|.
Mouse   151 -FLHFENFTGV------DDADVDS----------EMDPEQP-------------VTEDESIEEIF 185

  Fly   138 SESAERKAT-------EEGKTGKAADDVKNTPESGEDA------------NKAAAKEPSGTPVAA 183
            .|: :..||       |.|.......:..:.|||...|            .|...|:.|....:.
Mouse   186 EET-QTNATCNYEPKSENGVEVAMGSEQDSMPESRHGAVERPFLPLAPQTEKQKNKQRSEVDGSN 249

  Fly   184 SSEATVPAPGSASSSN----------------------SPL------PGT-------------PP 207
            ...|.:|||.|...:|                      |||      |||             |.
Mouse   250 EKTALLPAPTSLGDTNVTVEEQFNSINLSFQDDPDSSPSPLGNMLEIPGTSSPSTSQELPFCQPK 314

  Fly   208 KYSNPHNLTIGARLEALSVEGNWLPARI------------------------VEV--NETEQT-- 244
            |.|.|....:|..:.|......|.|.||                        ||.  :.:|:.  
Mouse   315 KKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVANRRPYREYYVEAFGDPSEKAWV 379

  Fly   245 ---LLVRFERNHKLKVSPSTSGSFQEWMAIKSERLRQRLSNRVLPVFEL---------------D 291
               .:|.||..|:.:..|......::    |.:..|.::..::|..:|.               :
Mouse   380 AGKAIVMFEGRHQFEELPVLRKRGKQ----KEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKN 440

  Fly   292 EKCMAR-----------WSGPRKFPGTIRKLLGNDTYEVLFDDGYV--------------KNVRA 331
            :||::.           :......|.:...||......:.||..:.              |:...
Mouse   441 QKCVSSSVKLDSEEDMPFEDCTNDPDSEHLLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSSDN 505

  Fly   332 VHMNKMPKQLPPVQV-AEEGASKSPTPVGTPVSSAPVAPKRAS------TGSLGGSSGSSGSKKS 389
            :....:.|.|.|.:. .||...|.|..:|....|..|:.|:||      ..||.|||.:.||...
Mouse   506 IKRTSVKKDLVPFESRKEERRGKIPDNLGLDFISGGVSDKQASNELSRIANSLTGSSTAPGSFLF 570

  Fly   390 KCAPQ---RRDWPLLDMASLDIASLGLPE----IPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPT 447
            ..:.|   :.|:...|..||.    ||.|    ..|.||                      :|  
Mouse   571 SSSVQNTAKTDFETPDCDSLS----GLSESALISKHSGE----------------------KK-- 607

  Fly   448 VIVQDWRLPPGW-----IKHMY-------QRSNVLGKWDVILVSPSGKRFRSKSDLKLFLES--- 497
                  :|.||.     ::..|       :|||.:   .|...|..|     .|||.....:   
Mouse   608 ------KLQPGQVCSSKVQLCYVGAGDEEKRSNSV---SVSTTSDDG-----CSDLDPTEHNSGF 658

  Fly   498 QNLVYN-PDVYD-----FSIHR-----------RRAKDINAYVYTHGY-----------NPQ--- 531
            ||.|.. .|.:|     .|:|:           .|.|:....:.|:.:           .|:   
Mouse   659 QNSVLGITDAFDKTENALSVHKNETQYSRYPVTNRIKEKQKSLITNSHADHLMGSTKTMEPETAE 723

  Fly   532 -------------PPPKPRPMDVSMNSTLDQSITSQHSLP----------------STPMPVK-- 565
                         |.|||:|      ...:..:|::.|.|                .|.:|:|  
Mouse   724 LSQVNLSDLKISSPIPKPQP------EFRNDGLTTKFSAPPGIRNENPLTKGGLANQTLLPLKCR 782

  Fly   566 -------ESQYMEAPVASLMPPAELMSPQTQPADETKPKIEAEILEASEGGTSQLMLADPHVVEN 623
                   :.::.|:|..:                ||....|...|:.....|:...||  ::.::
Mouse   783 QPKFRSIKCKHKESPAVA----------------ETSATSEDLSLKCCSSDTNGSPLA--NISKS 829

  Fly   624 GFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHP 688
            |    .|..:|:.:|::       .||....|.....::|...|..| :|:....::::...|..
Mouse   830 G----KGEGLKLLNNMH-------EKTRDSSDIETAVVKHVLSELKE-LSYRSLSEDVSDSGTAK 882

  Fly   689 SSIDQV--EAVPKNQIPNQ---------QFFAKMHQQDLQQSRSFKRQSVSATAT-----SSTPS 737
            :|...:  .|..:|.||.:         .....||....::.|....|::::..|     .|:.|
Mouse   883 ASKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLASYRTPDRGDCSSGS 947

  Fly   738 DITPTKALLSPKMEPPSVSP--TVESGIKQEDVSLDAGPTQSFNPSLS----------------- 783
            .:..:|.|:.....|.|..|  :.:..:.|.....|:..:...:.|||                 
Mouse   948 PVGTSKVLVLGSSTPNSEKPGDSTQDSVHQSPGGGDSALSGELSSSLSSLASDKRELPACGKIRS 1012

  Fly   784 -----RSCKRAR-------------LSPSKRPSGSRKSNRQRSQRRPILS--------------D 816
                 |:|.||:             :.||..|...:...:::..|.|.::              :
Mouse  1013 NCIPRRNCGRAKPSSKLRETISAQMVKPSVNPKALKTERKRKFSRLPAVTLAANRLGNKESGSVN 1077

  Fly   817 NPAGHGLTEQDVEETRQSF------NTPTPDTRIDSKKRRSGAATTPISSID---------SPAM 866
            .|:..|..:...||..|..      :|...|...|||.::|    .|..:::         .|.:
Mouse  1078 GPSRGGAEDPGKEEPLQQMDLLRNEDTHFSDVHFDSKAKQS----DPDKNLEKEPSFENRKGPEL 1138

  Fly   867 GDSVSTPSSNDQT-DINAAL-----------APPPAETLSKAPQYIKENGELIRIVRMRQEEIIN 919
            |..::|  .||:. .:|..:           .|.|.:..::..:  |||.|....|.:..:.:..
Mouse  1139 GSEMNT--ENDELHGVNQVVPKKRWQRLNQRRPKPGKRANRFRE--KENSEGAFGVLLPADAVQK 1199

  Fly   920 CICEYGE---------EDGL----------MIQCELCLCWQHGACNG-IVKEADVPDKYVCYICR 964
            ...:|.|         ||..          .:...|.:|.:.....| :.||..:|.........
Mouse  1200 AREDYLEQRAPPTSKPEDSAADPNHGSHSESVAPRLNVCEKSSVGMGDVEKETGIPSLMPQTKLP 1264

  Fly   965 NPQRGRDSMRFKHDQDWLFEGKLPVAAYHTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVK 1029
            .|....:..|.:....||.|   ....|........||.::.::.|.::....|     .|||. 
Mouse  1265 EPAIRSEKKRLRKPSKWLLE---YTEEYDQIFAPKKKQKKVQEQVHKVSSRCED-----ESLLA- 1320

  Fly  1030 INIARNRCHPKLYLWAKKWDEDNLDSTALTP--VKRAK--LEAP-----------DLP----NVP 1075
                  ||.|...  .|:.||::|.||...|  ::|..  ||.|           :||    :||
Mouse  1321 ------RCQPSAQ--NKQVDENSLISTKEEPPVLEREAPFLEGPLAQSDLGVTHAELPQLTLSVP 1377

  Fly  1076 -----QPEAAIDPEE 1085
                 .|..|::.||
Mouse  1378 VAPEASPRPALESEE 1392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MBD-R2NP_731688.2 THAP 4..86 CDD:283206 16/77 (21%)
TUDOR 292..329 CDD:119391 8/61 (13%)
MeCP2_MBD 449..522 CDD:238690 22/104 (21%)
PHD_SF 919..963 CDD:304600 10/63 (16%)
Nsd1NP_032765.3 MSH6_like 320..430 CDD:99898 18/113 (16%)
TNG2 <1453..1587 CDD:227367
PHD1_NSD1_2 1546..1587 CDD:277118
PHD2_NSD1 1593..1639 CDD:277120
PHD3_NSD1 1640..1693 CDD:277123
PHD4_NSD1 1710..1749 CDD:277126
WHSC1_related 1755..1849 CDD:99899
AWS 1902..1940 CDD:375420
SET_NSD1 1942..2083 CDD:380987
PHD5_NSD1 2121..2163 CDD:277129
C5HCH 2162..2211 CDD:375464
PHA03307 2255..>2576 CDD:223039
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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