DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and set-5

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001256612.1	Gene:	set-5 / 179973	WormBaseID:	WBGene00008145	Length:	1558	Species:	Caenorhabditis elegans

Alignment Length:	1051	Identity:	200/1051 - (19%)
Similarity:	347/1051 - (33%)	Gaps:	344/1051 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 ELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQVAEEGASK 353
            |..|.|...|.         ||.:.|        |||.|.             |.:.::...:|.
Worm   163 EDSENCRREWK---------RKYIQN--------DGYWKP-------------PELSISASSSST 197

  Fly   354 S---PTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPE 415
            |   |.|..||.:                      .::.|.           :.|:...|..:|.
Worm   198 SQIDPEPSKTPFN----------------------EEQEKL-----------LKSIINQSKIIPM 229

  Fly   416 IPHDGEWTCHWVNDQPIGTE----------GFLI---VGEHQKPTVIVQDWRLPPG-------WI 460
            :|...:..|| |..|..|:|          |.||   .....|..:::.|.||...       ::
Worm   230 MPRHTKHLCH-VFKQEFGSEKTVEEIDDDLGKLISDFTSRVMKSNIVLNDDRLMNAITLRNVLYV 293

  Fly   461 KHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNPDVYDFSIHR--RRAKDINAYV 523
            ..:....||| :|    :..:|.......:.:|||...:   ..|....::|.  |:.||...|:
Worm   294 TSVSVEENVL-EW----LHDAGVNVFLNKNRQLFLMKYS---KTDKSPLNVHSLDRKTKDYELYL 350

  Fly   524 Y--------------------------------------------THGYNPQPPPKPRPMDVSMN 544
            .                                            ...::|.|||.|.|:::|..
Worm   351 KEQMTKLLAGMPDESGRETSQAANEVEVQAAMENVEEGEIVPESGNRVFSPLPPPPPPPLEMSRE 415

  Fly   545 STLDQSITSQHSLPSTPMPVKESQYMEAPV--ASLMPPAELMSPQTQPADETKPKIEAEILEASE 607
            |:...|::.: |:....:.:||:.:.:...  :|.:...|......:....||   :||..:.|:
Worm   416 SSPISSVSGK-SIKLLTLQLKETMHKKNSFFHSSYVKKEETGIINGESIQVTK---KAESSQFSD 476

  Fly   608 GGTSQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHV 672
              :|.::|.:|||                       ..:..:...||          |.|.....
Worm   477 --SSPILLVNPHV-----------------------HTEAPEPTPKE----------HMERKWST 506

  Fly   673 SHCPKMQELAVKRTHPSSID-------------QVEAVPKNQIPNQQFFAKMHQQDLQQSRSFKR 724
            :|...|.||....|..||..             ::.|......|.::...::..:..::.:..:|
Worm   507 THSGSMGELQRPVTSQSSRKSSRWDVTEEDLKRKLSATSSTHNPRERASVELETRQSEEIQKLQR 571

  Fly   725 ---------QSVSAT-----ATSSTPSDITPTKALLSPKME---PPSVSPTVESGIKQEDV---S 769
                     .|:..|     |....|.:.:.|..|||...:   ..|.||. :|.....|:   |
Worm   572 LVNVIKPRDDSLEGTSNLDAANREIPIEASSTAPLLSRSFQFWRERSKSPD-DSAQNHSDLHGTS 635

  Fly   770 LDAGPTQSFNP---SLSRSCKRARLSPSKRPSGSRKSNR--QRSQRRP----------------- 812
            |.:.|....||   :::::..:..:|...||..::||..  |.:|..|
Worm   636 LKSRPDAQKNPIPQAVAKTMLKFPVSTLDRPVNTKKSMAFGQEAQIMPKSSVFVNNAVKIPQKFV 700

  Fly   813 ----ILSDNP--AGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAMG---- 867
                ..||||  |.:.::.|:..:. ....:.||..::.|:.|.|||   |.||.|...:.
Worm   701 IVKEASSDNPNAAENPVSTQNTVDL-HDIPSKTPQQKVTSENRGSGA---PNSSEDQQKLDEIAP 761

  Fly   868 -------DSVSTPSSNDQTDINAALAPPPAETLSKA--PQYIKENGELIRIVRMRQEEIINCICE 923
                   |.||..|.:|..::.       |||..|:  |:.|  .|:                .:
Worm   762 TTQILPEDPVSVQSRSDVCEVT-------AETSQKSVGPERI--GGD----------------AQ 801

  Fly   924 YGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLP 988
            ...|:.:.::..:.|   ||.      .:..|.|.|       |.|:.:.....:|..:  ...|
Worm   802 SSSENTVSVRNRVDL---HGI------PSKTPQKLV-------QSGKSAQSSTENQQQI--EMTP 848

  Fly   989 VAAYHTANPQATKQFELLK----RSHTLTGNLLDAKRSMHSLLVKINIARNRC-HPKLYLWAKKW 1048
            .|...:.||.:.:....:|    .||:|:.:....:..|....:..|..:||. ..::.|.:.|.
Worm   849 EARILSKNPISAQSKTPVKEERPESHSLSESFASTQHPMKISEISENSTQNRSDSSRIGLRSVKL 913

  Fly  1049 DE---------------DNLDSTALTPVKRAKLEAPDLPNVPQPEAAIDPEECQYRLIEHIKVQQ 1098
            ::               .|.:..|..|::...||..:..:| |||..||.||.:......|....
Worm   914 EQIPSRTIKVEEPTDFPSNSEPEAQIPLETRTLEPSEASSV-QPEPPIDQEEAENDENPEILTPN 977

  Fly  1099 SLVLDRLNDIEAEMDELEKEDTLDDLKDADISTTKEALATFIKEL-ETMKRLA---------KLN 1153
            |..:|:        ||.:..|..|...|:|:...:..|...|..| |..::::         ||.
Worm   978 SPTIDQ--------DEAQNSDAPDASADSDLPKLEPELERMIDFLVEITEKISVPAIKTDIWKLY 1034

  Fly  1154 QVANMKQTLRD 1164
            | |.|||.:::
Worm  1035 Q-ARMKQNVKE 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	10/36 (28%)
		MeCP2_MBD	449..522	CDD:238690	16/81 (20%)
		PHD_SF	919..963	CDD:304600	7/43 (16%)
set-5	NP_001256612.1	SET	36..151	CDD:214614
		PHA03309	<793..1008	CDD:165564	49/259 (19%)
		SPK	1006..1118	CDD:214732	11/40 (28%)
		PTZ00108	<1115..1328	CDD:240271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030