DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and mes-4

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_506333.1	Gene:	mes-4 / 179824	WormBaseID:	WBGene00003222	Length:	898	Species:	Caenorhabditis elegans

Alignment Length:	290	Identity:	51/290 - (17%)
Similarity:	92/290 - (31%)	Gaps:	97/290 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   621 VENGFAFIGGLKVKIQDNL--YVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAV 683
            :::|........:..::||  ..|..|:|..|..|                             .
Worm   654 IDDGDEITFSYNMNNEENLPDCECGAENCMGTMGK-----------------------------A 689

  Fly   684 KRTHPSSIDQVE-AVPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLS 747
            ||..|...|..| |..||         |..::...::::.|.|......|:|..|:|:|:|
Worm   690 KREKPEVADSSEKAAKKN---------KSSKKKSVKNQNRKSQEAGKNGTASKKSEISPSK---- 741

  Fly   748 PKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRP 812
                                            ||.|.:...:.:..:..|....|.|.:::..:|
Worm   742 --------------------------------PSTSSASSTSFVQQASWPISQNKKNLKKNSNQP 774

  Fly   813 ILSDNPAGHGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGAATTPISSIDSPAMGDSVSTPSSND 877
            :..........||.:..|..|...:|.      |.:.|:.:::||.:.          .:.|..|
Worm   775 VADTGSTLSTSTELNFHEKPQELLSPV------SSRSRAASSSTPRAQ----------KSKSRRD 823

  Fly   878 QTDINAALAPPPAETLSKAPQYIKENGELI 907
            ..:..|    ||.:..:.:.|.|:|.|:.|
Worm   824 DVESEA----PPVKRATPSLQTIQETGKAI 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600
mes-4	NP_506333.1	PHD_SF	207..269	CDD:304600
mes-4	NP_506333.1	SET	537..671	CDD:214614	1/16 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030