DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and set-26

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001370101.1	Gene:	set-26 / 178463	WormBaseID:	WBGene00013106	Length:	1645	Species:	Caenorhabditis elegans

Alignment Length:	1230	Identity:	228/1230 - (18%)
Similarity:	371/1230 - (30%)	Gaps:	464/1230 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 ADQRALQHASVEGTTETPGNAQSSTNDDVIKATVD-----------------QIVAQI--LSESA 141
            |:...:....::|.:|.| .|..:|::......||                 |.:.||  ...:|
Worm    28 AEPIVMAQEPIQGVSEDP-QASEATHEAPDNYPVDHQMENQEFYQEPQIPEPQQIPQIPVFQPAA 91

  Fly   142 ---------ERKATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVAASSEATVPAPGSASS 197
                     :::|...|:...|||....|.|     .:.||:.|:...|...|:.......:...
Worm    92 YNPPNYVAPQQRANNFGEPAAAADSRPLTEE-----EQLAAERPTEDTVWIDSDDDTDVEEAILR 151

  Fly   198 SNSPLPGTPPKYSNPHNLTIGARLEALSVEGNWLPA-RIVEVNETEQTLLVRFERNHKLKVSPST 261
            :|..||.:...|..|.                  || ||:                      ..|
Worm   152 ANFWLPYSDHNYDPPD------------------PADRII----------------------LPT 176

  Fly   262 SGSFQEWMAIKSERLRQRLSNRVLP-VFELDEKC--MARWS-----GPRKFPGTIRKLLGNDTYE 318
            .|.|                    | :..|||.|  :.:|.     ||.. |||
Worm   177 EGPF--------------------PCIAGLDEDCNIVKQWMPEDAVGPGS-PGT----------- 209

  Fly   319 VLFDDGYVKNVRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSS-- 381
                 .|.:|      .:....||...||.:   :...||...:.:.|:.  .|...|:||:.
Worm   210 -----QYRRN------QQTGGGLPSTSVAPQ---QQQLPVRHNIQNRPMV--AAQPFSIGGNQVE 258

  Fly   382 -GSSGSKKSKCAPQR---RDWPLLDMASLDIASLGLP---EIPHDGEWTCHWVNDQPIGTEGFLI 439
             |..|...|: ..||   ||.|...:.: |..: |||   ::|.......:.:|.
Worm   259 YGGIGGMDSR-MQQRGVVRDGPQYRVMN-DFGN-GLPMRGQLPPRNSPAANAINR---------- 310

  Fly   440 VGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQNLVYNP 504
            |.|.|                :.||.::...|.....:.:|:..                   .|
Worm   311 VREQQ----------------QQMYHQAGARGSLQQRVPAPAAP-------------------TP 340

  Fly   505 DVYDFSIHRRRAKDINAYVYTHGYNP--QPPPKPRPMDVSMNSTLDQSITSQHSLP---STPMPV 564
            ..|...        :|| |...|.||  :.||:.||      ..:..:..:..:.|   :.||..
Worm   341 GSYQHI--------VNA-VPVGGANPMRRVPPQARP------GMIGGAANNNRARPIHVTRPMDT 390

  Fly   565 KESQYMEAPVASLMPPAEL-------MSPQTQ---------------PADETKPKIEAEILEASE 607
            :|.::..||.|: .||..:       |:|:.:               ||...:...|..:::...
Worm   391 QEFEHPVAPAAA-APPRRVVDVAPHRMTPEQRQELQQMNRQRAAPQFPAAAAQRSAEKIVIQQRP 454

  Fly   608 GGTSQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEF-AEH 671
            |.:|..                            .||...|    :||.|....|...:.. .||
Worm   455 GASSSR----------------------------APRPSMA----QEDLLRSPTRRLSERVPQEH 487

  Fly   672 VSHCPKMQELAVKRTH------PSSIDQVEAVPKNQIPNQQFFAKMHQQDL-------------- 716
            .:...:.:...||.|.      |.:.||:.|....:.|.::..|....:|:
Worm   488 QTPVLEPRRFQVKVTDTYSTPIPKASDQLPAQLTEEDPPEESAAAAAPEDVPDAAPEDPPKGILK 552

  Fly   717 ----------QQSRSFKRQSVS----ATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQED 767
                      :::..|.|.:..    .::.|..|.|..|      |.:.||...|.|.....|::
Worm   553 PTPPHRMTQEEKNAHFARLTTDKEKPTSSASILPQDAAP------PHVPPPPPPPLVLRPHHQDE 611

  Fly   768 V------SLDAGPTQSFNP----SLSRSCKRARLSPSK--RPSGSRKSNRQRSQRRPILSDNPAG 820
            .      ..::.|.|...|    ::|:.....|.|..:  ..|||..:.|||:      ....|.
Worm   612 TLAMVQSVFESKPRQPDTPKDKEAISKIADLLRFSADEFTGQSGSSAAARQRT------VSGSAA 670

  Fly   821 HGLTEQDVEETRQSFNTPTPDTRIDSKKRRSGA------ATTPISSIDSPAMGDSVSTPSSNDQT 879
            ...|.|...:.:|..:...|   :|.:||.|..      ...|:.....|      ..||....|
Worm   671 RAQTYQMHHQQQQQHHHQMP---MDQRKRHSSGRYDALMGAMPLQQQPPP------PPPSQFQHT 726

  Fly   880 DI-------------------------NAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEI-- 917
            |.                         .|...||.|:|::.:.:    ||...:......|.|
Worm   727 DSIAHRPRGRPKGTRHPSVAVQPQRSGGARTLPPRAQTVAMSAR----NGANAKNSDSESEGIDE 787

  Fly   918 -------INCICEYGEEDGLMIQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSMRF 975
                   :.|.|.....||..|:||.|..|||.||.|:..:::. .||.|.:|. |:|
Worm   788 AAEESWTMRCHCGMDHGDGDTIECEGCKTWQHMACMGLTLKSNT-SKYKCEMCL-PRR------- 843

  Fly   976 KHDQDWLFEGKLPVAAYHTANPQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPK 1040
                       |||:.                         .:|.|....:|.::..|
Worm   844 -----------LPVSK-------------------------AEAAREQERILNRLRAA------- 865

  Fly  1041 LYLWAKKWDEDNLDSTALTPVKRAKLEAPDLPNVPQPEAAIDPEECQYRLIEHIKVQQSLVLDRL 1105
                |||....:      .||::.:...|.......| .|:..:..:.|:.:            |
Worm   866 ----AKKQKRKS------EPVEQKQKSQPSTSRKSAP-MALQQQPAEPRVAQ------------L 907

  Fly  1106 NDIEAE-------MDELEKEDTLDDLKDADISTTKEALATFIKE-LETM--KRLAKLNQV 1155
            ||...:       |::....|||    .|:....|:|...|::| :|.:  ..|.::.||
Worm   908 NDYSKQASALLFGMEQTAGADTL----LAESRLHKKARRMFVEEAVEALVTTDLVQIRQV 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	9/43 (21%)
		MeCP2_MBD	449..522	CDD:238690	7/72 (10%)
		PHD_SF	919..963	CDD:304600	17/43 (40%)
set-26	NP_001370101.1	PRK03427	<9..>135	CDD:235124	22/112 (20%)
		PHD_Bye1p_SIZ1_like	796..839	CDD:277045	17/43 (40%)
		SET_SETD5-like	935..1067	CDD:380927	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930