DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MBD-R2 and set-9

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001379880.1	Gene:	set-9 / 177196	WormBaseID:	WBGene00017482	Length:	1623	Species:	Caenorhabditis elegans

Alignment Length:	1073	Identity:	195/1073 - (18%)
Similarity:	325/1073 - (30%)	Gaps:	405/1073 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 DTYEVLFDDGYVKNVRAVHMNKM--PKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRAST--G 375
            |.|.|   |..::|....|..::  |:|:|.:.|.:..|...|.         .|||::.:.  |
Worm    56 DNYPV---DHQMENQEFYHEPQIPEPQQIPQIPVFQPAAYNPPN---------YVAPQQRANNFG 108

  Fly   376 SLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDI------------ASLGLPE------------- 415
            ....:.....:::.:.|.:|   |..|...:|.            |:..||.
Worm   109 EPAAADARPLTEQEQLAAER---PTEDTVWIDSDDDTDVEEAILRANFWLPYSDHNYDPPDPADR 170

  Fly   416 --IPHDGEWTC------------HWVNDQPIG-------------TEGFL----IVGEHQ----- 444
              :|.:|.:.|            .|:.:..:|             ..|.|    :..:.|
Worm   171 IILPTEGPFPCIAGLDEDCNIVKQWMPEDAVGPGSPGTQYRRNQQAGGGLPSTSVASQQQQLPVR 235

  Fly   445 -----KPTVIVQDWRLPPGWIKH------MYQRSNVLGKWDVILVSPSGKRFRSKSD-------- 490
                 :|.|..|.:.:....:::      |.||.          |...|.::|..:|
Worm   236 HNIQNRPMVAAQPFSIGGNQVEYGGMDSRMQQRG----------VVRDGPQYRVMNDFGNGLPMR 290

  Fly   491 -------------LKLFLESQNLVYNPDVYDFSIHRRRA---KDINAYVYTH--------GYNP- 530
                         :....|.|..:|:......|:.:|.|   .|.....|.|        |.||
Worm   291 GLLPPRNSPAANAINRAREQQQQMYHQAGARGSLQQRAAPAPADPTPGSYQHIVNAVPGGGANPM 355

  Fly   531 -QPPPKPRPMDVSMNSTLDQSITSQHSLP---STPMPVKESQYMEAPVASLMPPAEL-------M 584
             :.||:.||      ..:..:..:..:.|   :.||..:|.::..||.|:  ||..:       |
Worm   356 RRVPPQARP------GMIGGAANNNRARPTHVTRPMDTQEFEHPVAPAAA--PPHRVVDVAPHRM 412

  Fly   585 SPQTQ---------------PADETKPKIEAEILEASEGGTSQLMLADPHVVENGFAFIGGLKVK 634
            :|:.:               ||...:...|..:::...|.:|:
Worm   413 TPEQRQELQQMNRQRAAPQFPAAAAQRSAEVIVIQQRPGASSR---------------------- 455

  Fly   635 IQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEF-AEHVSHCPKMQELAVKRTH------PSSID 692
                   .||...|    :||.|....|...:.. .||.:...:.:...||.|.      |.:.|
Worm   456 -------APRPSMA----QEDLLRSPTRRLSERVPQEHQTPVLEPRRFQVKVTDTYSTPIPKASD 509

  Fly   693 QVEAVPKNQIPNQQFFAKMHQQDL------------------------QQSRSFKRQSVS----A 729
            |:.|....:.|.::..|....:|:                        :::..|.|.:..    .
Worm   510 QLPAQLTEEDPPEESAAAAAPEDVPDAAPEDPPKVILKPTPPHRMTQEEKNAHFARLTTDKEKPT 574

  Fly   730 TATSSTPSDITPTKALLSPKMEPP----------------SVSPTVESGIKQEDVSLDAGPTQSF 778
            ::||..|.|..|      |.:.||                .|....||..:|.|...|
Worm   575 SSTSILPQDAAP------PHVPPPPPPLVLRPHHQDETLAMVQSVFESKPRQPDTPKD------- 626

  Fly   779 NPSLSRSCKRARLSPSK--RPSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPD 841
            ..::|:.....|.|..:  ..|||..:.|||:      ....|....|.| :...:|..:...|
Worm   627 KETISKIADLLRFSADEFTGQSGSSAAARQRT------VSGSAARAQTYQ-MHHQQQQHHHQMP- 683

  Fly   842 TRIDSKKRRSGA------ATTPISSIDSPAMGDSVSTPSSNDQTDI------------------- 881
              :|.:||.|..      ...|:.....|       .||....||.
Worm   684 --MDQRKRPSSGRYDALMGAMPLQQQPPP-------PPSQFQHTDSIAHRPRGRPKGTRHPSVAV 739

  Fly   882 ------NAALAPPPAETLSKAPQYIKENGELIRIVRMRQEEI---------INCICEYGEEDGLM 931
                  .|...||.|:|::.:.:    ||...:......|.|         :.|.|.....||..
Worm   740 QPQRSGGARTLPPRAQTVAMSAR----NGANAKNSDSESEGIDEAAEESWTMRCHCGMDHGDGDT 800

  Fly   932 IQCELCLCWQHGACNGIVKEADVPDKYVCYICRNPQRGRDSMRFKHDQDWLFEGKLPVAAYHTAN 996
            |:||.|..|||.||.|:..:::. .||.|.:|. |:|                  |||:.
Worm   801 IECEGCKTWQHMACMGLTLKSNT-SKYKCEMCL-PRR------------------LPVSK----- 840

  Fly   997 PQATKQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNLDSTALTPV 1061
                                .:|.|....:|.::..|..:        .|:..|         ||
Worm   841 --------------------AEAAREQERILNRLRAAARK--------QKRKSE---------PV 868

  Fly  1062 -KRAKLEAPDLPNVPQPEAAIDPEECQYRLIEHIKVQQSLVLDRLNDIEAEMDELEKEDTLDDLK 1125
             ::.|...|.......|.|...|.|.:...:.....|.|.:|       ..|::....|||
Worm   869 EQKQKSSQPSTSRKSAPMALQQPAEPRVAQLNDYSKQASALL-------FGMEQTAGADTL---- 922

  Fly  1126 DADISTTKEALATFIKE-LETM--KRLAKLNQV 1155
            .|:....|:|...|::| :|.:  ..|.::.||
Worm   923 LAESRLHKKARRMFVEEAVEALVTTDLVQIRQV 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	4/13 (31%)
		MeCP2_MBD	449..522	CDD:238690	15/102 (15%)
		PHD_SF	919..963	CDD:304600	17/43 (40%)
set-9	NP_001379880.1	PRK03427	<9..>132	CDD:235124	19/90 (21%)
		Med15	196..>373	CDD:312941	30/192 (16%)
		PHD_Bye1p_SIZ1_like	788..831	CDD:277045	17/43 (40%)
		SET_SETD5-like	927..1059	CDD:380927	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930