DRSC/TRiP Functional Genomics Resources

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Protein Alignment MBD-R2 and set-16

DIOPT Version :9

Sequence 1:NP_731688.2 Gene:MBD-R2 / 41498 FlyBaseID:FBgn0038016 Length:1169 Species:Drosophila melanogaster
Sequence 2:NP_499819.3 Gene:set-16 / 176802 WormBaseID:WBGene00011729 Length:2475 Species:Caenorhabditis elegans


Alignment Length:1276 Identity:216/1276 - (16%)
Similarity:399/1276 - (31%) Gaps:423/1276 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VTYHSFPLDPI-----IRAIWIKNSRI--SLERQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRV 79
            :|:| .|:|..     ::.:.....|:  |||.|:.|:        |:...|.....:.::|.:.
 Worm  1051 ITHH-LPMDVYQVYQDLKRVKFDRERLNGSLEEQLNKA--------RKQKKNLAAKKRQMVKTQT 1106

  Fly    80 FPTVFPWGKMDTAEIEADQRAL---------QHASVEGTTETPGNAQSSTNDDVIKATVDQIVAQ 135
            ....:....:|..  |:||:.|         ..|.:|.........:|:.:|.|:|..:.:...:
 Worm  1107 AAPDYDGRNIDLN--ESDQQTLATLTEQIKVTQAEIELHRRDLKKHESNLSDFVMKHGILRNEHE 1169

  Fly   136 ILSESAERKATEEGKTGKAADDVKNTPESGEDANKAAAKEPSGTPVAASSEATVPAP-------- 192
            :..|..:..|..:.:....||::.......:...:.   .|   ||..:.:|.:..|        
 Worm  1170 VKREDVQLSAIRDQQYAAHADEMLAQQAQNQGLGQV---HP---PVLVAPQAAISLPMLNQQQQH 1228

  Fly   193 ----GSASSSNSPLPG------TPPKYS--NPHNLTIGARLEALSVEGNWLPARIVEVNETEQTL 245
                ........| ||      .||:..  |.||..|..|:                       |
 Worm  1229 HQRMMQMQMRGGP-PGQFMMRAQPPQQPQINMHNHEIAKRM-----------------------L 1269

  Fly   246 LVRFERNHKLK--------VSPSTSGSFQEWMAI------KSERLRQRLSNRVLPVFELDEKCMA 296
            :.:|...|.:.        ..|.....:....||      .:||...:.:.:..|...:.::.|.
 Worm  1270 MQQFRNAHPVMGGIRHDEITDPIMRDVYDCLEAIVFDVHTVAEREAMQAAGQQPPPPHIMQRMMQ 1334

  Fly   297 RW----SGPRK-FPGTIRKLLGNDTYEVLFDDGYVKNVRAVHMNKMPKQLPPVQVAEEGASKSPT 356
            :.    .|||. .||...:|.|                     .::|:|.||||:.:        
 Worm  1335 QHPGGPGGPRLIMPGQFPQLQG---------------------RRIPQQPPPVQLPQ-------- 1370

  Fly   357 PVGTPVSSAPVAPKRASTGSLGGSSGSSGSKKSKCAPQRRDWPLLDMASLDIASLGLPEIPHDG- 420
                 |...|  ||.|:....||.:....:.....|.:...|    :..:.:.....|:||... 
 Worm  1371 -----VDVDP--PKTAAKRKKGGGNPKKNASSYPAAGEYDAW----IEQMRMRFRLCPDIPKKQK 1424

  Fly   421 ---------EWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVI 476
                     |:..|.:.|..                            ::...:|:.::|::..:
 Worm  1425 EPRLNRPGCEFVSHGLTDMA----------------------------VRATKKRTPLVGEFGAM 1461

  Fly   477 LVSPSGKRF--RSKSDLKLFLESQNLV-YNPDVYDFSIHRRRAKDINAYVYTHGYNPQPPPKPRP 538
            .|....:.|  ..:.:..:..:..||. ..|.:..|:::.               ||.|      
 Worm  1462 RVKRGTRLFGNEERGEKSIMFQDLNLYQVEPQIRLFALYN---------------NPLP------ 1505

  Fly   539 MDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAPVASLMP----------PAELMSPQTQPADE 593
                   |::..:...          :|.|.::.|.::|..          ..:.:..:.:..:|
 Worm  1506 -------TMEDDVFRD----------EEDQIIDKPTSALQKLLNKKRGASGAMDHIRSRARYMEE 1553

  Fly   594 TK--PKIEA----EILEASEGGTSQLMLADPHVVENGFAFIGGLKVKIQDNLYVCPREDCAKTYR 652
            |.  |..|.    |.:||.|..|.:|:.....:.|..         .:.:...||.|        
 Worm  1554 TNIPPAPERGMFYENVEAEEEVTVELVFNTCDITEES---------SVDEKKDVCGR-------- 1601

  Fly   653 KEDFLLIHIRHYHKEFAEHVSHCPKMQELA--VKRTHPSSIDQVEAVPKNQIPNQQFFAKMHQQD 715
                       .|::..:.::   ...|:|  ::.|.|.|       |.::.|..:......|| 
 Worm  1602 -----------LHEQIRDLLA---IKDEVAWSMEDTPPES-------PVSRSPEPEATVGAVQQ- 1644

  Fly   716 LQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQSFNP 780
                         .::||..||:.|..:.....:.|...|:|.    ||:|.|.    |:||.|.
 Worm  1645 -------------TSSTSRAPSEATEREIKREVEEEAAPVAPE----IKREIVE----PSQSQNS 1688

  Fly   781 SLSRSCKRARLSPSK-------------RPSGSRKSNRQRSQRRPILSDNPAGHGL----TEQDV 828
            |..::|::|..|.|.             .|:||..:.|    ..|:....|...|.    :|:..
 Worm  1689 SQCKNCQKALESHSSTSIVTVKAEKLNLAPTGSVVTTR----AAPVPPGVPGAPGAPIAPSEEKT 1749

  Fly   829 EETRQSFNTPTPDTRIDSKK---RRSGAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPA 890
            :|...||         .|||   ..:.|...|::..:..|....||                  .
 Worm  1750 KEELASF---------CSKKCYYELASATRAPLTEEEVAAAEQHVS------------------E 1787

  Fly   891 ETLSKAPQYIKENGELIRIV--------RMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNG 947
            |..:|..|.:.||  :::.|        ::.......|:.:.|..:.:.|               
 Worm  1788 EVYNKLKQVLTEN--IVKAVSQGKKPDPQLTSPRDTRCMMDEGRRENVTI--------------- 1835

  Fly   948 IVKEADVPDKYVCYICRNPQRGRDSMRFKHDQDW------LFEGKLPVA---AYHTANPQ---AT 1000
                  ||...:......|:........:..:||      :::..:.:.   |:|..:|:   ..
 Worm  1836 ------VPVASLIGAVEAPKEAPSQRAAEAAEDWKAYTKSIWDSFVNIQQQHAHHILSPKIGVPH 1894

  Fly  1001 KQFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDNLDSTALTPVKRAK 1065
            ..:.|.||.....|.:.|.:.:....|:.:. .....|....||:.:..|:  .:..||.|.||.
 Worm  1895 PPYHLDKRICVFCGGIGDGETTRCGRLISLT-EFYWVHVNCALWSAEVFEN--QTGGLTNVDRAV 1956

  Fly  1066 LEAPD--LPNVPQPEAAIDPEEC-------QYRLI------------------EHIKV-QQSLV- 1101
            |.|..  ..:..:|.|::   :|       .|.::                  :|.|| .|::| 
 Worm  1957 LRAAQTACDHCKRPGASV---KCHKMNCGVNYHVLCAMQNNGFFIKDRTFICKQHEKVSNQAIVG 2018

  Fly  1102 -LDRLNDIEAEMDELEKEDTLDDLKDADISTTKEALATFIK 1141
             ||.|..|..:.||......|.:|.|......:....||.|
 Worm  2019 RLDALRRIYVKRDENTMLTRLFELTDGPTLCMRLGAFTFYK 2059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MBD-R2NP_731688.2 THAP 4..86 CDD:283206 13/70 (19%)
TUDOR 292..329 CDD:119391 8/41 (20%)
MeCP2_MBD 449..522 CDD:238690 8/75 (11%)
PHD_SF 919..963 CDD:304600 5/43 (12%)
set-16NP_499819.3 PHD_SF 42..84 CDD:276966
PHD4_KMT2C_like 427..477 CDD:276987
PHD5_KMT2C_like 479..524 CDD:276988
PHD6_KMT2C_like 554..604 CDD:276989
DUF1351 1060..>1163 CDD:284492 20/112 (18%)
ePHD2_KMT2C_like 1904..2008 CDD:277136 18/109 (17%)
FYRN 2055..2104 CDD:283589 3/5 (60%)
FYRC 2112..2199 CDD:197781
SET 2333..2457 CDD:214614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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