DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and Y14H12B.2

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_494697.1	Gene:	Y14H12B.2 / 173735	WormBaseID:	WBGene00021192	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	320	Identity:	64/320 - (20%)
Similarity:	112/320 - (35%)	Gaps:	91/320 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 ILEASEGGTSQLMLAD---PHVVENGF-AFIGGLKVKIQDNLYV-----CPREDCAK-------- 649
            :.:.|:..:..|||.|   .:..|.|: ..:..|::|::.:|.|     ...||..|
Worm    31 LAKKSKNISRPLMLKDLFSAYKEEAGYPGTVATLRLKLRWDLAVKIPLAANFEDDEKAQMLFATS 95

  Fly   650 TYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEAVPKNQIPNQQF---FAKM 711
            |..||:||                     :.|..|.|  ..:|.::.:...:....:|   .||.
Worm    96 TSAKEEFL---------------------KRLREKAT--VDVDNLQRITYYKSTKLEFKGKHAKG 137

  Fly   712 HQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTVESGIKQEDVSLDAGPTQ 776
            :..||.|.||   .|.|..:.:.:|           |:::..:.:...|...:.|.:.:|    |
Worm   138 NFADLSQRRS---SSASNQSVAQSP-----------PQLQQINSADLQEEEDEDEIIVID----Q 184

  Fly   777 SFNPSLSRSCKRARLSPSKRPSGSRKSNRQRSQRRPILSDNPAGHGLTEQDVEETRQSFNTPTPD 841
            :.||:::            .|...:.:.:...|...|  |.|...|.....|......::...|.
Worm   185 TSNPAIN------------YPKMKQIAVKTEFQEPRI--DYPPSDGSDTISVINVNAGYSLYCPQ 235

  Fly   842 TRIDSKKRRS-----GAATTPISSIDSPAMGDSVSTPSSNDQTDINAALAPPPA--ETLS 894
            ........||     |...|.:..:.|..|.:.::..|::         |||||  ||.|
Worm   236 PAFYPNVDRSMFTAMGQMMTGVLQMQSQMMKEVLNRGSTS---------APPPAAPETTS 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391
		MeCP2_MBD	449..522	CDD:238690
		PHD_SF	919..963	CDD:304600
Y14H12B.2	NP_494697.1	SPK	27..131	CDD:367941	23/122 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1844
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900