DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MBD-R2 and Mecp2

DIOPT Version :9

Sequence 1:	NP_731688.2	Gene:	MBD-R2 / 41498	FlyBaseID:	FBgn0038016	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001075448.1	Gene:	Mecp2 / 17257	MGIID:	99918	Length:	501	Species:	Mus musculus

Alignment Length:	697	Identity:	132/697 - (18%)
Similarity:	200/697 - (28%)	Gaps:	288/697 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 SPSTSGSFQEWMAIKSERLRQRLSNRVLPVFELDEKCMARWSGPRKFPGTIRKLLGNDTYEVLFD 322
            :||..|...|     .|||.::..::.|.  .|.:|       |.||     |....|..|
Mouse    13 APSGGGGGGE-----EERLEEKSEDQDLQ--GLRDK-------PLKF-----KKAKKDKKE---- 54

  Fly   323 DGYVKNVRAVHMNKMPKQLPPVQVAEEGASKSPTPVGTPVSSAPVAPKRASTGSLGGSSGSSGSK 387
                 :....|....|......:.||.|.:::....|    |||..|:            :|.|.
Mouse    55 -----DKEGKHEPLQPSAHHSAEPAEAGKAETSESSG----SAPAVPE------------ASASP 98

  Fly   388 KSKCAPQRRDWPLLDMASLDIASLGLPEIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQD 452
            |.:.:..|...|:.|                                          .||
Mouse    99 KQRRSIIRDRGPMYD------------------------------------------DPT----- 116

  Fly   453 WRLPPGWIKHMYQRSN--VLGKWDVILVSPSGKRFRSKSDLKLFLES-QNLVYNPDVYDFSI--- 511
              ||.||.:.:.||.:  ..||:||.|::|.||.||||.:|..:.|. .:...:|:.:||::
Mouse   117 --LPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGR 179

  Fly   512 ---HRRRAKDINAYVYTHGYNPQPPPKPRPMDVSMNSTLDQSITSQHSLPSTPMPVKESQYMEAP 573
               .||..|              ||.||:                                  :|
Mouse   180 GSPSRREQK--------------PPKKPK----------------------------------SP 196

  Fly   574 VASLMPPAELMSPQTQPADETKPKIEA-------EILEASEGGTSQLMLADPHVVENGFAFIGGL 631
            .|   |.......:.:.:...:||..|       .:||.|.|   :|::..|.....|....||
Mouse   197 KA---PGTGRGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPG---KLVVKMPFQASPGGKGEGG- 254

  Fly   632 KVKIQDNLYVCPREDCAKTYRKEDFLLIHIRHYHKEFAEHVSHCPKMQELAVKRTHPSSIDQVEA 696
                                                     ......|.:.:||  |....:.||
Mouse   255 -----------------------------------------GATTSAQVMVIKR--PGRKRKAEA 276

  Fly   697 VPKNQIPNQQFFAKMHQQDLQQSRSFKRQSVSATATSSTPSDITPTKALLSPKMEPPSVSPTV-- 759
            .|               |.:.:.|..|..||.|.|.:....     ||:....:.  ||..||
Mouse   277 DP---------------QAIPKKRGRKPGSVVAAAAAEAKK-----KAVKESSIR--SVHETVLP 319

  Fly   760 -ESGIKQEDVSLDAGPTQSFNPSL-----------SRSCKRARLSPSKRPSGSRKSNRQRSQRRP 812
             :....:|.||::.  .:...|.|           .::||    ||.::...|....|..|...|
Mouse   320 IKKRKTRETVSIEV--KEVVKPLLVSTLGEKSGKGLKTCK----SPGRKSKESSPKGRSSSASSP 378

  Fly   813 ILSDNPAGHGLTEQ--------------DVEETRQSFNTPTPDTRIDS-----KKRRSGAATTPI 858
            ...::...|..:|.              :.|.:....:.|.|.....|     |..|.|:.
Mouse   379 PKKEHHHHHHHSESTKAPMPLLPSPPPPEPESSEDPISPPEPQDLSSSICKEEKMPRGGSL---- 439

  Fly   859 SSIDSPAMGDSVSTPSSNDQTDINAALAPPPAETLSKAPQYIKENGE 905
                     :|...|....:|.      |..|.|.:.|.:| |..||
Mouse   440 ---------ESDGCPKEPAKTQ------PMVATTTTVAEKY-KHRGE 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MBD-R2	NP_731688.2	THAP	4..86	CDD:283206
		TUDOR	292..329	CDD:119391	7/36 (19%)
		MeCP2_MBD	449..522	CDD:238690	26/81 (32%)
		PHD_SF	919..963	CDD:304600
Mecp2	NP_001075448.1	MBD	109..186	CDD:128673	28/125 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12132
eggNOG	1	0.900	-	-		E1_KOG4161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900